{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:08:38Z","timestamp":1785409718378,"version":"3.56.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000275","name":"Leverhulme Trust","doi-asserted-by":"publisher","award":["RPG-2015-226"],"award-info":[{"award-number":["RPG-2015-226"]}],"id":[{"id":"10.13039\/501100000275","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic Biomedical Sciences","award":["209458\/Z\/17\/Z"],"award-info":[{"award-number":["209458\/Z\/17\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"DOI":"10.1164\/rccm.201805-0925ed","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T10:35:05Z","timestamp":1528367705000},"page":"1355-1356","source":"Crossref","is-referenced-by-count":26,"title":["New Rules for Club Development: New Insights into Human Small Airway Epithelial Club Cell Ontogeny and Function"],"prefix":"10.1093","volume":"198","author":[{"given":"Charlotte H.","family":"Dean","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Snelgrove","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,1]]},"reference":[{"key":"2026032023285803900_bib1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1165\/ajrcmb.10.6.8003339","article-title":"Cell number and distribution in human and rat airways","volume":"10","author":"Mercer","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032023285803900_bib2","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1513\/pats.200805-041HR","article-title":"Airway epithelial cells: current concepts and challenges","volume":"5","author":"Crystal","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"2026032023285803900_bib3","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1242\/dev.02407","article-title":"Epithelial stem cells of the lung: privileged few or opportunities for many?","volume":"133","author":"Rawlins","year":"2006","journal-title":"Development"},{"key":"2026032023285803900_bib4","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1164\/ajrccm.159.5.9806044","article-title":"Number and proliferation of Clara cells in normal human airway epithelium","volume":"159","author":"Boers","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032023285803900_bib5","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1242\/dmm.006031","article-title":"Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling","volume":"3","author":"Rock","year":"2010","journal-title":"Dis Model Mech"},{"key":"2026032023285803900_bib6","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.stem.2009.04.002","article-title":"The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium","volume":"4","author":"Rawlins","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2026032023285803900_bib7","doi-asserted-by":"crossref","first-page":"L643","DOI":"10.1152\/ajplung.00155.2003","article-title":"In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations","volume":"286","author":"Hong","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026032023285803900_bib8","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026032023285803900_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0006-3495(89)82648-7","article-title":"Resolvability of free energy changes for oxygen binding and subunit association by human hemoglobin","volume":"56","author":"Straume","year":"1989","journal-title":"Biophys J"},{"key":"2026032023285803900_bib10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1165\/ajrcmb.17.3.2774","article-title":"Pulmonary cytochrome P450 monooxygenase and Clara cell differentiation in mice","volume":"17","author":"Fanucchi","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032023285803900_bib11","first-page":"L348","article-title":"Clara cell secretory protein deficiency increases oxidant stress response in conducting airways","volume":"275","author":"Mango","year":"1998","journal-title":"Am J Physiol"},{"key":"2026032023285803900_bib12","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0022-3565(25)33589-5","article-title":"Xenobiotic metabolism in Clara cells and alveolar type II cells isolated from lungs of rats treated with beta-naphthoflavone","volume":"225","author":"Jones","year":"1983","journal-title":"J Pharmacol Exp Ther"},{"key":"2026032023285803900_bib13","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.4049\/jimmunol.171.2.1051","article-title":"Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection","volume":"171","author":"Wang","year":"2003","journal-title":"J Immunol"},{"key":"2026032023285803900_bib14","doi-asserted-by":"crossref","first-page":"e0116507","DOI":"10.1371\/journal.pone.0116507","article-title":"Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway","volume":"10","author":"Gomi","year":"2015","journal-title":"PLoS One"},{"key":"2026032023285803900_bib15","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1164\/rccm.201710-2107OC","article-title":"Ontogeny and biology of human small airway epithelial club cells","volume":"198","author":"Zuo","year":"2018","journal-title":"Am J Respir Crit Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/198\/11\/1355\/67120644\/ajrccm_198_11_1355.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/198\/11\/1355\/67120644\/ajrccm_198_11_1355.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:30:54Z","timestamp":1774063854000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/198\/11\/1355\/8498432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,1]]},"references-count":15,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,12,1]]},"published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201805-0925ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,12]]},"published":{"date-parts":[[2018,12,1]]}}}