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Specific IgE response against a range of common allergens was determined, combined with airway immune-inflammatory status and correlated to clinical outcomes. Clinically relevant patient clusters, based on sensitization pattern and airway immune profiles (\u201cimmunoallertypes\u201d), were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>A high frequency of sensitization to multiple allergens was detected in bronchiectasis, exceeding that in a comparator cohort with allergic rhinitis (n\u2009=\u2009149). Sensitization was associated with poor clinical outcomes, including decreased pulmonary function and more severe disease. \u201cSensitized bronchiectasis\u201d was classified into two immunoallertypes: one fungal driven and proinflammatory, the other house dust mite driven and chemokine dominant, with the former demonstrating poorer clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Allergic sensitization occurs at high frequency in patients with bronchiectasis recruited from different global centers. Improving endophenotyping of sensitized bronchiectasis, a clinically significant state, and a \u201ctreatable trait\u201d permits therapeutic intervention in appropriate patients, and may allow improved stratification in future bronchiectasis research and clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201807-1355oc","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T17:17:21Z","timestamp":1538155041000},"page":"842-853","source":"Crossref","is-referenced-by-count":89,"title":["Distinct \u201cImmunoallertypes\u201d of Disease and High Frequencies of Sensitization in Non\u2013Cystic Fibrosis Bronchiectasis"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1726-7700","authenticated-orcid":false,"given":"Miche\u00e1l","family":"Mac Aog\u00e1in","sequence":"first","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, 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