{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:01:19Z","timestamp":1772593279784,"version":"3.50.1"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100008269","name":"MICHR","doi-asserted-by":"publisher","award":["UL1TR000433"],"award-info":[{"award-number":["UL1TR000433"]}],"id":[{"id":"10.13039\/100008269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"HHV-6 Foundation Dharam Ablashi Research"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL127805"],"award-info":[{"award-number":["HL127805"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K99HL139996"],"award-info":[{"award-number":["K99HL139996"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>\u201cNoninfectious\u201d pulmonary complications are significant causes of morbidity and mortality after allogeneic hematopoietic cell transplant. Early-onset viral reactivations or infections are common after transplant. Whether the first-onset viral infection causes noninfectious pulmonary complications is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether the first-onset viral infection within 100 days after transplant predisposes to development of noninfectious pulmonary complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective review of 738 allogeneic hematopoietic cell transplant patients enrolled from 2005 to 2011. We also established a novel bone marrow transplantation mouse model to test whether herpesviral reactivation after transplant causes organ injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>First-onset viral infections with human herpesvirus 6 or Epstein-Barr virus within 100 days after transplant increase the risk of developing idiopathic pneumonia syndrome (adjusted hazard ratio [aHR], 5.52; 95% confidence interval [CI], 1.61\u201318.96; P\u2009=\u20090.007; and aHR, 9.21; 95% CI, 2.63\u201332.18; P\u2009=\u20090.001, respectively). First infection with human cytomegalovirus increases risk of bronchiolitis obliterans syndrome (aHR, 2.88; 95% CI, 1.50\u20135.55; P\u2009=\u20090.002) and grade II\u2013IV acute graft-versus-host disease (aHR, 1.59; 95% CI, 1.06\u20132.39; P\u2009=\u20090.02). Murine roseolovirus, a homolog of human herpesvirus 6, can also be reactivated in the lung and other organs after bone marrow transplantation. Reactivation of murine roseolovirus induced an idiopathic pneumonia syndrome\u2013like phenotype and aggravated acute graft-versus-host disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>First-onset herpesviral infection within 100 days after allogeneic hematopoietic cell transplant increases risk of pulmonary complications. Experimentally reactivating murine roseolovirus causes organ injury similar to phenotypes seen in human transplant recipients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201809-1635oc","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T16:21:56Z","timestamp":1549902116000},"page":"63-74","source":"Crossref","is-referenced-by-count":41,"title":["First-Onset Herpesviral Infection and Lung Injury in Allogeneic Hematopoietic Cell Transplantation"],"prefix":"10.1093","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3096-409X","authenticated-orcid":false,"given":"Xiaofeng","family":"Zhou","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3214-380X","authenticated-orcid":false,"given":"David N.","family":"O\u2019Dwyer","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9711-6215","authenticated-orcid":false,"given":"Meng","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly K.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Phoenix Children\u2019s Hospital, Phoenix, Arizona; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Trulik","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew M.","family":"Chadwick","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy C.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Bulte","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Sekerak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A.","family":"Wilke","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-4029","authenticated-orcid":false,"given":"Swapneel J.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-7264","authenticated-orcid":false,"given":"Wayne M.","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4387-7673","authenticated-orcid":false,"given":"Susan","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-4940","authenticated-orcid":false,"given":"Gregory A.","family":"Yanik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3051-745X","authenticated-orcid":false,"given":"Bethany B.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and"},{"name":"Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"2026030321314931300_bib1","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/bmt.2014.151","article-title":"Pulmonary complications in hematopoietic SCT: a prospective study","volume":"49","author":"Lucena","year":"2014","journal-title":"Bone Marrow Transplant"},{"key":"2026030321314931300_bib2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1164\/rccm.200309-1322SO","article-title":"Pulmonary complications of solid organ and hematopoietic stem cell transplantation","volume":"170","author":"Kotloff","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321314931300_bib3","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1164\/rccm.2007-413ST","article-title":"An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome","volume":"183","author":"Panoskaltsis-Mortari","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321314931300_bib4","first-page":"389","article-title":"National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 diagnosis and staging working group report","volume-title":"Biol Blood Marrow Transplant","author":"Jagasia","year":"2015"},{"key":"2026030321314931300_bib5","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1164\/rccm.201410-1818OC","article-title":"Budesonide\/formoterol for bronchiolitis obliterans after hematopoietic stem cell transplantation","volume":"191","author":"Bergeron","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321314931300_bib6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1055\/s-0036-1584793","article-title":"Herpesvirus respiratory infections in immunocompromised patients: epidemiology, management, and outcomes","volume":"37","author":"Reid","year":"2016","journal-title":"Semin Respir Crit Care Med"},{"key":"2026030321314931300_bib7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1086\/338624","article-title":"High risk of death due to bacterial and fungal infection among cytomegalovirus (CMV)-seronegative recipients of stem cell transplants from seropositive donors: evidence for indirect effects of primary CMV infection","volume":"185","author":"Nichols","year":"2002","journal-title":"J Infect Dis"},{"key":"2026030321314931300_bib8","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1182\/blood-2014-12-617035","article-title":"Idiopathic pneumonia syndrome after hematopoietic cell transplantation: evidence of occult infectious etiologies","volume":"125","author":"Seo","year":"2015","journal-title":"Blood"},{"key":"2026030321314931300_bib9","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1164\/rccm.201712-2456OC","article-title":"Lung dysbiosis, inflammation, and injury in hematopoietic cell transplantation","volume":"198","author":"O\u2019Dwyer","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321314931300_bib10","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/mi.2015.85","article-title":"Bone marrow transplantation alters lung antigen-presenting cells to promote TH17 response and the development of pneumonitis and fibrosis following gammaherpesvirus infection","volume":"9","author":"Zhou","year":"2016","journal-title":"Mucosal Immunol"},{"key":"2026030321314931300_bib11","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1164\/rccm.201501-0161OC","article-title":"Inhibition of neutrophil extracellular trap formation after stem cell transplant by prostaglandin E2","volume":"193","author":"Domingo-Gonzalez","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321314931300_bib12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/1753425918757898","article-title":"Characterization of innate immune viral sensors in patients following allogeneic hematopoietic stem cell transplantation","volume":"24","author":"Caddy","year":"2018","journal-title":"Innate Immun"},{"key":"2026030321314931300_bib13","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1016\/j.ajpath.2011.08.002","article-title":"Severe gammaherpesvirus-induced pneumonitis and fibrosis in syngeneic bone marrow transplant mice is related to effects of transforming growth factor-\u03b2","volume":"179","author":"Coomes","year":"2011","journal-title":"Am J Pathol"},{"key":"2026030321314931300_bib14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1164\/rccm.200711-1648OC","article-title":"Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated graft-versus-host disease","volume":"178","author":"Mauermann","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321314931300_bib15","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1182\/blood-2014-07-590232","article-title":"Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation","volume":"125","author":"Varelias","year":"2015","journal-title":"Blood"},{"key":"2026030321314931300_bib16","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1182\/blood-2008-06-162420","article-title":"In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations","volume":"113","author":"Carlson","year":"2009","journal-title":"Blood"},{"key":"2026030321314931300_bib17","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1182\/blood.V85.5.1263.bloodjournal8551263","article-title":"Immunosuppressive effect of human herpesvirus 6 on T-cell functions: suppression of interleukin-2 synthesis and cell proliferation","volume":"85","author":"Flamand","year":"1995","journal-title":"Blood"},{"key":"2026030321314931300_bib18","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/mi.2017.85","article-title":"Bone marrow transplant-induced alterations in Notch signaling promote pathologic Th17 responses to \u03b3-herpesvirus infection","volume":"11","author":"Gurczynski","year":"2018","journal-title":"Mucosal Immunol"},{"key":"2026030321314931300_bib19","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1186\/s12885-015-1616-z","article-title":"Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation","volume":"15","author":"D\u00f6ring","year":"2015","journal-title":"BMC Cancer"},{"key":"2026030321314931300_bib20","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.bbmt.2015.07.022","article-title":"Impact of human herpesvirus-6 reactivation on outcomes of allogeneic hematopoietic stem cell transplantation","volume":"21","author":"Aoki","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"2026030321314931300_bib21","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3324\/haematol.2016.144428","article-title":"Management of Epstein-Barr virus infections and post-transplant lymphoproliferative disorders in patients after allogeneic hematopoietic stem cell transplantation: Sixth European Conference on Infections in Leukemia (ECIL-6) guidelines","volume":"101","author":"Styczynski","year":"2016","journal-title":"Haematologica"},{"key":"2026030321314931300_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbmt.2016.12.069","article-title":"Early post-transplant viral infections and the incidence of acute and chronic noninfectious pulmonary complications following hematopoietic stem cell transplantation (HSCT)","volume":"23","author":"Zhou","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"2026030321314931300_bib23","doi-asserted-by":"crossref","first-page":"e02463","DOI":"10.1128\/JVI.02463-16","article-title":"A murine herpesvirus closely related to ubiquitous human herpesviruses causes T-cell depletion","volume":"91","author":"Patel","year":"2017","journal-title":"J Virol"},{"key":"2026030321314931300_bib24","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.4049\/jimmunol.168.6.3088","article-title":"Murine sclerodermatous graft-versus-host disease, a model for human scleroderma: cutaneous cytokines, chemokines, and immune cell activation","volume":"168","author":"Zhang","year":"2002","journal-title":"J Immunol"},{"key":"2026030321314931300_bib25","first-page":"1","article-title":"ipw: an R package for inverse probability weighting","volume":"43","author":"van der Wal","year":"2011","journal-title":"J Stat Softw"},{"key":"2026030321314931300_bib26","first-page":"95","volume-title":"Marginal structural models versus structural nested models as tools for causal inference.","author":"Robins","year":"2000"},{"key":"2026030321314931300_bib27","volume-title":"R: a language and environment for statistical computing. 3.3.2 ed.","author":"R Core Team","year":"2018"},{"key":"2026030321314931300_bib28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1084\/jem.113.5.831","article-title":"A new mouse virus causing necrosis of the thymus in newborn mice","volume":"113","author":"Rowe","year":"1961","journal-title":"J Exp Med"},{"key":"2026030321314931300_bib29","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/j.bbmt.2018.04.021","article-title":"Human herpesvirus-6B reactivation is a risk factor for grades II to IV acute graft-versus-host disease after hematopoietic stem cell transplantation: a systematic review and meta-analysis","volume":"24","author":"Phan","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"2026030321314931300_bib30","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.bbmt.2009.12.534","article-title":"Strong association between respiratory viral infection early after hematopoietic stem cell transplantation and the development of life-threatening acute and chronic alloimmune lung syndromes","volume":"16","author":"Versluys","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"2026030321314931300_bib31","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1164\/rccm.200212-1468OC","article-title":"Airflow obstruction after myeloablative allogeneic hematopoietic stem cell transplantation","volume":"168","author":"Chien","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321314931300_bib32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbmt.2018.08.021","article-title":"Risk factors for parainfluenza virus lower respiratory tract disease after hematopoietic cell transplantation","volume":"25","author":"Seo","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"key":"2026030321314931300_bib33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0166-0934(88)90066-3","article-title":"Antibody reactivity with HBLV (HHV-6) in U.S. populations","volume":"21","author":"Saxinger","year":"1988","journal-title":"J Virol Methods"},{"key":"2026030321314931300_bib34","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1086\/428060","article-title":"Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation","volume":"40","author":"Zerr","year":"2005","journal-title":"Clin Infect Dis"},{"key":"2026030321314931300_bib35","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1128\/CMR.00122-14","article-title":"Laboratory and clinical aspects of human herpesvirus 6 infections","volume":"28","author":"Agut","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"2026030321314931300_bib36","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/jmv.24161","article-title":"Large-scale multiplex polymerase chain reaction assay for diagnosis of viral reactivations after allogeneic hematopoietic stem cell transplantation","volume":"87","author":"Inazawa","year":"2015","journal-title":"J Med Virol"},{"key":"2026030321314931300_bib37","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1097\/INF.0000000000000824","article-title":"Reactivation of human herpes virus-6 after pediatric stem cell transplantation: risk factors, onset, clinical symptoms and association with severity of acute graft-versus-host disease","volume":"34","author":"Verhoeven","year":"2015","journal-title":"Pediatr Infect Dis J"},{"key":"2026030321314931300_bib38","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/bmt.2009.326","article-title":"Human herpes virus 6 infection is a hallmark of cord blood transplant in adults and may participate to delayed engraftment: a comparison with matched unrelated donors as stem cell source","volume":"45","author":"Chevallier","year":"2010","journal-title":"Bone Marrow Transplant"},{"key":"2026030321314931300_bib39","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1097\/TP.0b013e318289958b","article-title":"Human herpesvirus 6 infection after allogeneic stem cell transplantation: incidence, outcome, and factors associated with HHV-6 reactivation","volume":"95","author":"Jeulin","year":"2013","journal-title":"Transplantation"},{"key":"2026030321314931300_bib40","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/QCO.0b013e3283553362","article-title":"Human herpesvirus 6 (HHV-6) disease in the setting of transplantation","volume":"25","author":"Zerr","year":"2012","journal-title":"Curr Opin Infect Dis"},{"key":"2026030321314931300_bib41","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1056\/NEJM199307153290302","article-title":"Human herpesvirus 6 in lung tissue from patients with pneumonitis after bone marrow transplantation","volume":"329","author":"Cone","year":"1993","journal-title":"N Engl J Med"},{"key":"2026030321314931300_bib42","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0140-6736(91)90137-E","article-title":"Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation","volume":"338","author":"Carrigan","year":"1991","journal-title":"Lancet"},{"key":"2026030321314931300_bib43","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.bbmt.2011.12.579","article-title":"Early human herpesvirus type 6 reactivation after allogeneic stem cell transplantation: a large-scale clinical study","volume":"18","author":"Dulery","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"2026030321314931300_bib44","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbmt.2011.07.018","article-title":"The complex relationship between human herpesvirus 6 and acute graft-versus-host disease","volume":"18","author":"Pichereau","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"2026030321314931300_bib45","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.3109\/10428194.2016.1157873","article-title":"Early human herpes virus type 6 reactivation in umbilical cord blood allogeneic stem cell transplantation","volume":"57","author":"Cirrone","year":"2016","journal-title":"Leuk Lymphoma"},{"key":"2026030321314931300_bib46","first-page":"1643","article-title":"Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation","volume-title":"J Allergy Clin Immunol","author":"Admiraal","year":"2017"},{"key":"2026030321314931300_bib47","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/cid\/cix804","article-title":"Kinetics of double-stranded DNA viremia after allogeneic hematopoietic cell transplantation","volume":"66","author":"Hill","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2026030321314931300_bib48","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1172\/JCI119612","article-title":"The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide","volume":"100","author":"Panoskaltsis-Mortari","year":"1997","journal-title":"J Clin Invest"},{"key":"2026030321314931300_bib49","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/0046-8177(95)90174-4","article-title":"The histological spectrum of pulmonary graft-versus-host disease in bone marrow transplant recipients","volume":"26","author":"Yousem","year":"1995","journal-title":"Hum Pathol"},{"key":"2026030321314931300_bib50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/cid\/civ215","article-title":"Reduced mortality of cytomegalovirus pneumonia after hematopoietic cell transplantation due to antiviral therapy and changes in transplantation practices","volume":"61","author":"Erard","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2026030321314931300_bib51","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1083-8791(03)00287-8","article-title":"Cytomegalovirus in hematopoietic stem cell transplant recipients: current status, known challenges, and future strategies","volume":"9","author":"Boeckh","year":"2003","journal-title":"Biol Blood Marrow Transplant"},{"key":"2026030321314931300_bib52","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ccm.2005.06.013","article-title":"Cytomegalovirus pneumonia in transplant recipients","volume":"26","author":"Ison","year":"2005","journal-title":"Clin Chest Med"},{"key":"2026030321314931300_bib53","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1182\/blood-2002-03-0993","article-title":"Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity","volume":"101","author":"Boeckh","year":"2003","journal-title":"Blood"},{"key":"2026030321314931300_bib54","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/sj.bmt.1702226","article-title":"Risk factors for treatment failures in patients receiving PCR-based preemptive therapy for CMV infection","volume":"25","author":"Einsele","year":"2000","journal-title":"Bone Marrow Transplant"},{"key":"2026030321314931300_bib55","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/sj.bmt.1705699","article-title":"Risk factors associated with late cytomegalovirus reactivation after allogeneic stem cell transplantation for hematological malignancies","volume":"40","author":"Ozdemir","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"2026030321314931300_bib56","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1164\/rccm.200911-1786OC","article-title":"Cytomegalovirus pneumonitis is a risk for bronchiolitis obliterans syndrome in lung transplantation","volume":"181","author":"Snyder","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321314931300_bib57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1164\/rccm.19311P19","article-title":"Bronchiolitis obliterans syndrome (BOS) following lung transplant","volume":"193","author":"Thomas","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321314931300_bib58","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1111\/j.1600-6143.2011.03663.x","article-title":"Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome","volume":"11","author":"Paraskeva","year":"2011","journal-title":"Am J Transplant"},{"key":"2026030321314931300_bib59","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1182\/blood.V67.4.1162.1162","article-title":"Cytomegalovirus infection after bone marrow transplantation: an association with acute graft-v-host disease","volume":"67","author":"Miller","year":"1986","journal-title":"Blood"},{"key":"2026030321314931300_bib60","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.bbmt.2010.03.020","article-title":"Evidence for a bidirectional relationship between cytomegalovirus replication and acute graft-versus-host disease","volume":"16","author":"Cantoni","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"2026030321314931300_bib61","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1182\/blood-2015-11-679639","article-title":"Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis","volume":"127","author":"Teira","year":"2016","journal-title":"Blood"},{"key":"2026030321314931300_bib62","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/tri.12689","article-title":"Re-examining the relationship between active cytomegalovirus (CMV) infection and acute graft-versus-host disease in allogeneic stem cell transplant recipients in the era of real-time PCR CMV assays","volume":"29","author":"Gim\u00e9nez","year":"2016","journal-title":"Transpl Int"},{"key":"2026030321314931300_bib63","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.4049\/jimmunol.0901871","article-title":"Induction of TGF-beta 1, not regulatory T cells, impairs antiviral immunity in the lung following bone marrow transplant","volume":"184","author":"Coomes","year":"2010","journal-title":"J Immunol"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/200\/1\/63\/67168936\/ajrccm_200_1_63.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/200\/1\/63\/67168936\/ajrccm_200_1_63.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:32:07Z","timestamp":1772591527000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/200\/1\/63\/8496786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,7,1]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201809-1635oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,7,1]]}}}