{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:21:34Z","timestamp":1791897694695,"version":"4.3.4"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K08 HL140087"],"award-info":[{"award-number":["K08 HL140087"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 CA203636"],"award-info":[{"award-number":["R01 CA203636"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U01 HL133232"],"award-info":[{"award-number":["U01 HL133232"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL130974"],"award-info":[{"award-number":["R01 HL130974"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL116473"],"award-info":[{"award-number":["R01 HL116473"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL122464"],"award-info":[{"award-number":["R01 HL122464"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL135142"],"award-info":[{"award-number":["R01 HL135142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL113264"],"award-info":[{"award-number":["R01 HL113264"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL137927"],"award-info":[{"award-number":["R01 HL137927"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01 HL092870"],"award-info":[{"award-number":["P01 HL092870"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL097163"],"award-info":[{"award-number":["R01 HL097163"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R33 HL120770"],"award-info":[{"award-number":["R33 HL120770"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Oddur Olafsson Fund","award":["141513-051"],"award-info":[{"award-number":["141513-051"]}]},{"name":"Icelandic Research Fund and Landspitali","award":["A-2015-030"],"award-info":[{"award-number":["A-2015-030"]}]},{"name":"Icelandic Research Fund and Landspitali","award":["A-2016-023"],"award-info":[{"award-number":["A-2016-023"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["N01-AG-1-2100"],"award-info":[{"award-number":["N01-AG-1-2100"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HHSN27120120022C"],"award-info":[{"award-number":["HHSN27120120022C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["27120120022C"],"award-info":[{"award-number":["27120120022C"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["141513-051"],"award-info":[{"award-number":["141513-051"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Icelandic Research Fund"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL111024"],"award-info":[{"award-number":["R01 HL111024"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL130974"],"award-info":[{"award-number":["R01 HL130974"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 135142"],"award-info":[{"award-number":["R01 135142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Icelandic Research Fund","award":["141513-051"],"award-info":[{"award-number":["141513-051"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Interstitial lung abnormalities (ILA) are radiologic abnormalities on chest computed tomography scans that have been associated with an early or mild form of pulmonary fibrosis. Although ILA have been associated with radiologic progression, it is not known if specific imaging patterns are associated with progression or risk of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the role of imaging patterns on the risk of death and ILA progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ILA (and imaging pattern) were assessed in 5,320 participants from the AGES-Reykjavik Study, and ILA progression was assessed in 3,167 participants. Multivariable logistic regression was used to assess factors associated with ILA progression, and Cox proportional hazards models were used to assess time to mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Over 5 years, 327 (10%) had ILA on at least one computed tomography, and 1,435 (45%) did not have ILA on either computed tomography. Of those with ILA, 238 (73%) had imaging progression, whereas 89 (27%) had stable to improved imaging; increasing age and copies of MUC5B genotype were associated with imaging progression. The definite fibrosis pattern was associated with the highest risk of progression (odds ratio, 8.4; 95% confidence interval, 2.7\u201325; P\u2009=\u20090.0003). Specific imaging patterns were also associated with an increased risk of death. After adjustment, both a probable usual interstitial pneumonia and usual interstitial pneumonia pattern were associated with an increased risk of death when compared with those indeterminate for usual interstitial pneumonia (hazard ratio, 1.7; 95% confidence interval, 1.2\u20132.4; P = 0.001; hazard ratio, 3.9; 95% confidence interval, 2.3\u20136.8;P\u2009&amp;lt;\u20090.0001), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In those with ILA, imaging patterns can be used to help predict who is at the greatest risk of progression and early death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201809-1652oc","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T18:34:23Z","timestamp":1548268463000},"page":"175-183","source":"Crossref","is-referenced-by-count":246,"title":["Imaging Patterns Are Associated with Interstitial Lung Abnormality Progression and Mortality"],"prefix":"10.1093","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8027-7450","authenticated-orcid":false,"given":"Rachel K.","family":"Putman","sequence":"first","affiliation":[{"name":"Pulmonary and Critical Care Division"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Gudmundsson","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Sleep, Faculty of Medicine, Landspital University Hospital and"},{"name":"Faculty of Medicine, University of Iceland, Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisli Thor","family":"Axelsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Iceland, Reykjavik, Iceland"},{"name":"Icelandic Heart Association, Kopavogur, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Radiology"},{"name":"Center for Pulmonary Functional Imaging, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medicine, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Radiology"},{"name":"Center for Pulmonary Functional Imaging, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yanagawa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medicine, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Radiology"},{"name":"Center for Pulmonary Functional Imaging, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra R.","family":"Miller","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Division"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudny","family":"Eiriksdottir","sequence":"additional","affiliation":[{"name":"Icelandic Heart Association, Kopavogur, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00edas F.","family":"Gudmundsson","sequence":"additional","affiliation":[{"name":"Icelandic Heart Association, Kopavogur, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Tomiyama","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medicine, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan O.","family":"Rosas","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Division"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Washko","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Division"},{"name":"Center for Pulmonary Functional Imaging, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Cho","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Division"},{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmundur","family":"Gudnason","sequence":"additional","affiliation":[{"name":"Icelandic Heart Association, Kopavogur, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Hatabu","sequence":"additional","affiliation":[{"name":"Department of Radiology"},{"name":"Center for Pulmonary Functional Imaging, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Hunninghake","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Division"},{"name":"Center for Pulmonary Functional Imaging, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"2026030321315097700_bib1","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1056\/NEJMoa1216076","article-title":"MUC5B promoter polymorphism and interstitial lung abnormalities","volume":"368","author":"Hunninghake","year":"2013","journal-title":"N Engl J Med"},{"key":"2026030321315097700_bib2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1056\/NEJMoa1007285","article-title":"Lung volumes and emphysema in smokers with interstitial lung abnormalities","volume":"364","author":"Washko","year":"2011","journal-title":"N Engl J Med"},{"key":"2026030321315097700_bib3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1164\/rccm.200812-1966OC","article-title":"Cigarette smoking is associated with subclinical parenchymal lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA)-lung study","volume":"180","author":"Lederer","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321315097700_bib4","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1001\/jama.2016.0518","article-title":"Association between interstitial lung abnormalities and all-cause mortality","volume":"315","author":"Putman","year":"2016","journal-title":"JAMA"},{"key":"2026030321315097700_bib5","first-page":"A1120","article-title":"Interstitial lung abnormalities and histopathologic correlates in patients undergoing lung nodule resection [abstract]","volume":"195","author":"Miller","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321315097700_bib6","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1164\/rccm.201703-0555OC","article-title":"High-attenuation areas on chest computed tomography and clinical respiratory outcomes in community-dwelling adults","volume":"196","author":"Podolanczuk","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321315097700_bib7","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.rmed.2010.05.014","article-title":"The radiological patterns of interstitial change at an early phase: over a 4-year follow-up","volume":"104","author":"Tsushima","year":"2010","journal-title":"Respir Med"},{"key":"2026030321315097700_bib8","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1183\/09031936.00201809","article-title":"Interstitial lung diseases in a lung cancer screening trial","volume":"38","author":"Sverzellati","year":"2011","journal-title":"Eur Respir J"},{"key":"2026030321315097700_bib9","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1164\/rccm.201512-2523OC","article-title":"Development and progression of interstitial lung abnormalities in the Framingham Heart Study","volume":"194","author":"Araki","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321315097700_bib10","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis. Evidence-based guidelines for diagnosis and management","volume":"183","author":"Raghu","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321315097700_bib11","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S2213-2600(14)70101-8","article-title":"Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001-11","volume":"2","author":"Raghu","year":"2014","journal-title":"Lancet Respir Med"},{"key":"2026030321315097700_bib12","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/aje\/kwk115","article-title":"Age, Gene\/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics","volume":"165","author":"Harris","year":"2007","journal-title":"Am J Epidemiol"},{"key":"2026030321315097700_bib13","doi-asserted-by":"crossref","first-page":"1700537","DOI":"10.1183\/13993003.00537-2017","article-title":"The MUC5Bpromoter polymorphism is associated with specific interstitial lung abnormality subtypes","volume":"50","author":"Putman","year":"2017","journal-title":"Eur Respir J"},{"key":"2026030321315097700_bib14","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMoa1013660","article-title":"A common MUC5B promoter polymorphism and pulmonary fibrosis","volume":"364","author":"Seibold","year":"2011","journal-title":"N Engl J Med"},{"key":"2026030321315097700_bib15","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1164\/rccm.201108-1574OC","article-title":"Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation","volume":"185","author":"Xu","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321315097700_bib16","first-page":"1577","article-title":"The high-resolution CT scan findings in familial interstitial pneumonia do not conform to those of idiopathic interstitial pneumonia","volume-title":"Chest","author":"Lee","year":"2012"},{"key":"2026030321315097700_bib17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S2213-2600(17)30433-2","article-title":"Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper","volume":"6","author":"Lynch","year":"2018","journal-title":"Lancet Respir Med"},{"key":"2026030321315097700_bib18","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1164\/rccm.201807-1255ST","article-title":"Diagnosis of idiopathic pulmonary fibrosis: an official ATS\/ERS\/JRS\/ALAT clinical practice guideline","volume":"198","author":"Raghu","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321315097700_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00330-015-3796-y","article-title":"Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking","volume":"26","author":"Araki","year":"2016","journal-title":"Eur Radiol"},{"key":"2026030321315097700_bib20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S2213-2600(17)30433-2","article-title":"Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper","volume":"6","author":"Lynch","year":"2018","journal-title":"Lancet Respir Med"},{"key":"2026030321315097700_bib21","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1148\/radiol.13120816","article-title":"Interstitial lung abnormalities in a CT lung cancer screening population: prevalence and progression rate","volume":"268","author":"Jin","year":"2013","journal-title":"Radiology"},{"key":"2026030321315097700_bib22","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1183\/13993003.00129-2016","article-title":"High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study","volume":"48","author":"Podolanczuk","year":"2016","journal-title":"Eur Respir J"},{"key":"2026030321315097700_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1164\/rccm.201604-0818LE","article-title":"Interstitial lung abnormalities are associated with acute respiratory distress syndrome","volume":"195","author":"Putman","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321315097700_bib24","doi-asserted-by":"crossref","first-page":"1601814","DOI":"10.1183\/13993003.01814-2016","article-title":"Computed tomographic findings in subjects who died from respiratory disease in the National Lung Screening Trial","volume":"49","author":"Pompe","year":"2017","journal-title":"Eur Respir J"},{"key":"2026030321315097700_bib25","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.ejrad.2015.01.021","article-title":"Interstitial lung abnormalities in treatment-na\u00efve advanced non-small-cell lung cancer patients are associated with shorter survival","volume":"84","author":"Nishino","year":"2015","journal-title":"Eur J Radiol"},{"key":"2026030321315097700_bib26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1164\/ajrccm.165.2.ats01","article-title":"American Thoracic Society\/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias: this joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001","volume":"165","author":"American Thoracic Society","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321315097700_bib27","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S2213-2600(15)00096-X","article-title":"CT staging and monitoring of fibrotic interstitial lung diseases in clinical practice and treatment trials: a position paper from the Fleischner Society","volume":"3","author":"Hansell","year":"2015","journal-title":"Lancet Respir Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/200\/2\/175\/67169036\/ajrccm_200_2_175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/200\/2\/175\/67169036\/ajrccm_200_2_175.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:32:03Z","timestamp":1772591523000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/200\/2\/175\/8496796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,7,15]]},"published-print":{"date-parts":[[2019,7,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201809-1652oc","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734910083.793564134","asserted-by":"object"}]},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,7]]}}}