{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:14:39Z","timestamp":1791616479854,"version":"4.3.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"NIH NHLBI"},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["U01 HL086622"],"award-info":[{"award-number":["U01 HL086622"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["U01 HL086649"],"award-info":[{"award-number":["U01 HL086649"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Poor outcomes of adults surviving critical illness are well documented, but data in children are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify factors associated with worse postdischarge function and health-related quality of life (HRQL) after pediatric acute respiratory failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed functional status at baseline, discharge, and 6 months after pediatric ICU discharge and HRQL 6 months after discharge in 2-week- to 17-year-olds mechanically ventilated for acute respiratory failure in the RESTORE (Randomized Evaluation of Sedation Titration for Respiratory Failure) trial. We assessed HRQL via Infant and Toddler Quality of Life Questionnaire-97 (&amp;lt;2 yr old) or Pediatric Quality of Life Inventory (\u22652 yr old). We categorized patients with normal baseline function as having impaired HRQL if scores were greater than 1 SD below mean norms for Infant and Toddler Quality of Life Questionnaire-97 growth and development or Pediatric Quality of Life Inventory total score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>One-fifth (n\u2009=\u2009192) of 949 patients declined in function from baseline to postdischarge; 20% (55\/271) had impaired growth and development; 19% (64\/343) had impaired HRQL. In multivariable analyses, decline in function was associated with baseline impaired function, prematurity, cancer, respiratory failure etiology, ventilation duration, and clonidine (odds ratio [OR]\u2009=\u20092.14; 95% confidence interval [CI]\u2009=\u20091.22\u20133.76). Independent predictors of impaired growth and development included methadone (OR\u2009=\u20092.27; 95% CI\u2009=\u20091.18\u20134.36) and inadequate pain management (OR\u2009=\u20092.94; 95% CI\u2009=\u20091.39\u20136.19). Impaired HRQL was associated with older age, non-white or Hispanic race, cancer, and inadequate sedation management (OR\u2009=\u20093.15; 95% CI\u2009=\u20091.74\u20135.72).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Postdischarge morbidity after respiratory failure is common and associated with admission factors, exposure to critical care therapies, and pain and sedation management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201810-1881oc","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T15:40:10Z","timestamp":1556552410000},"page":"900-909","source":"Crossref","is-referenced-by-count":82,"title":["Risk Factors for Functional Decline and Impaired Quality of Life after Pediatric Respiratory Failure"],"prefix":"10.1093","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-7186","authenticated-orcid":false,"given":"R. Scott","family":"Watson","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle, Washington"},{"name":"Center for Child Health, Behavior, and Development, Seattle Children\u2019s Research Institute, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5736-0304","authenticated-orcid":false,"given":"Lisa A.","family":"Asaro","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Hutchins","sequence":"additional","affiliation":[{"name":"Department of Patient Care Services, the Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Kris","family":"Bysani","sequence":"additional","affiliation":[{"name":"Medical City Children\u2019s Hospital, Dallas, Texas"},{"name":"Pediatric Acute Care Associates of North Texas, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1193-5464","authenticated-orcid":false,"given":"Elizabeth Y.","family":"Killien","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle, Washington"},{"name":"Harborview Injury Prevention and Research Center, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek C.","family":"Angus","sequence":"additional","affiliation":[{"name":"Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-8711","authenticated-orcid":false,"given":"David","family":"Wypij","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-6694","authenticated-orcid":false,"given":"Martha A. 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