{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:00:47Z","timestamp":1788328847768,"version":"build-2803163510"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Asphyxiated neonates with hypoxic ischemic encephalopathy (HIE) are at risk of myocardial dysfunction; however, echocardiography studies are limited and little is known about the relationship between hemodynamics and brain injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyze the association between severity of myocardial dysfunction and adverse outcome as defined by the composite of death and\/or abnormal magnetic resonance imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Neonates with HIE undergoing therapeutic hypothermia were enrolled. Participants underwent echocardiography at 24 hours, 72 hours (before rewarming), and 96 hours (after rewarming). Cerebral hemodynamics were monitored by near-infrared spectroscopy and middle cerebral artery Doppler.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Fifty-three patients with a mean gestation and birthweight of 38.8\u2009\u00b1\u20092.0 weeks and 3.33\u2009\u00b1\u20090.6 kg, respectively, were recruited. Thirteen patients (25%) had mild encephalopathy, 27 (50%) had moderate encephalopathy, and 13 (25%) had severe encephalopathy. Eighteen patients (34%) had an adverse outcome. Severity of cardiovascular illness (P\u2009&amp;lt;\u20090.001) and severity of neurologic insult (P\u2009=\u20090.02) were higher in neonates with adverse outcome. Right ventricle (RV) systolic performance at 24 hours was substantially lower than published normative data in all groups. At 24 hours, lower tricuspid annular plane systolic excursion (P\u2009=\u20090.004) and RV fractional area change (P\u2009&amp;lt;\u20090.001), but not pulmonary hypertension, were independently associated with adverse outcome on logistic regression. High brain regional oxygen saturation (P\u2009=\u20090.007) and low middle cerebral artery resistive index (P\u2009=\u20090.04) were associated with RV dysfunction on post hoc analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RV dysfunction is associated with the risk of adverse outcome in asphyxiated patients with HIE undergoing hypothermia. Echocardiography may be a valuable diagnostic and prognostic tool in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201903-0583oc","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T11:13:28Z","timestamp":1561720408000},"page":"1294-1305","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":71,"title":["Impaired Right Ventricular Performance Is Associated with Adverse Outcome after Hypoxic Ischemic Encephalopathy"],"prefix":"10.1093","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6227-6761","authenticated-orcid":false,"given":"Regan E.","family":"Giesinger","sequence":"first","affiliation":[{"name":"Division of Neonatology and"},{"name":"Department of Paediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr I.","family":"El Shahed","sequence":"additional","affiliation":[{"name":"Division of Neonatology and"},{"name":"Department of Paediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Castaldo","sequence":"additional","affiliation":[{"name":"Division of Neonatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm R.","family":"Breatnach","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, The Rotunda Hospital, Dublin, Ireland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vann","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary E.","family":"Whyte","sequence":"additional","affiliation":[{"name":"Division of Neonatology and"},{"name":"Department of Paediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afif F.","family":"El-Khuffash","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, The Rotunda Hospital, Dublin, Ireland; and"},{"name":"Department of Paediatrics, School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mertens","sequence":"additional","affiliation":[{"name":"Division of Cardiology, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"McNamara","sequence":"additional","affiliation":[{"name":"Division of Neonatology and"},{"name":"Department of Paediatrics and"},{"name":"Department of Physiology, The University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"issue":"1","key":"2026030321345907400_bib1","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2026030321345907400_bib2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jpeds.2017.03.053","article-title":"Erythropoietin and brain magnetic resonance imaging findings in hypoxic-ischemic encephalopathy: volume of acute brain injury and 1-year neurodevelopmental outcome","volume":"186","author":"Mulkey","year":"2017","journal-title":"J Pediatr"},{"key":"2026030321345907400_bib3","doi-asserted-by":"crossref","first-page":"16664","DOI":"10.1038\/s41598-017-16983-1","article-title":"Effect of Src kinase inhibition on cytochrome c, Smac\/DIABLO and apoptosis inducing factor (AIF) following cerebral hypoxia-ischemia in newborn piglets","volume":"7","author":"Kratimenos","year":"2017","journal-title":"Sci Rep"},{"key":"2026030321345907400_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fncel.2017.00296","article-title":"The beneficial effects of melatonin administration following hypoxia-ischemia in preterm fetal sheep","volume":"11","author":"Yawno","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"2026030321345907400_bib5","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/adc.2011.214205","article-title":"Cardiovascular dysfunction in infants with neonatal encephalopathy","volume":"97","author":"Armstrong","year":"2012","journal-title":"Arch Dis Child"},{"key":"2026030321345907400_bib6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s12024-013-9472-0","article-title":"Myocardial necrosis and infarction in newborns and infants","volume":"9","author":"Bamber","year":"2013","journal-title":"Forensic Sci Med Pathol"},{"key":"2026030321345907400_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0022-3476(80)80832-8","article-title":"Papillary muscle necrosis in a neonatal autopsy population: incidence and associated clinical manifestations","volume":"96","author":"Setzer","year":"1980","journal-title":"J Pediatr"},{"key":"2026030321345907400_bib8","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.resuscitation.2013.07.003","article-title":"Effect of cardiac compressions and hypothermia treatment on cardiac troponin I in newborns with perinatal asphyxia","volume":"84","author":"Liu","year":"2013","journal-title":"Resuscitation"},{"key":"2026030321345907400_bib9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/jp.2014.1","article-title":"Cardiac troponin I concentrations as a marker of neurodevelopmental outcome at 18 months in newborns with perinatal asphyxia","volume":"34","author":"Montaldo","year":"2014","journal-title":"J Perinatol"},{"key":"2026030321345907400_bib10","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.7754\/Clin.Lab.2016.151130","article-title":"Serum levels of cardiac troponin I in asphyxiated neonates predict mortality","volume":"62","author":"Zhou","year":"2016","journal-title":"Clin Lab"},{"key":"2026030321345907400_bib11","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3233\/NPM-16119","article-title":"Troponin-T as a biomarker in neonates with perinatal asphyxia","volume":"10","author":"Abiramalatha","year":"2017","journal-title":"J Neonatal Perinatal Med"},{"key":"2026030321345907400_bib12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1440-1754.2005.00626.x","article-title":"Comparison of serum cardiac troponin T and creatine kinase MB isoenzyme mass concentrations in asphyxiated term infants during the first 48 h of life","volume":"41","author":"Boo","year":"2005","journal-title":"J Paediatr Child Health"},{"key":"2026030321345907400_bib13","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1080\/14767058.2017.1338256","article-title":"Impacts of therapeutic hypothermia on cardiovascular hemodynamics in newborns with hypoxic-ischemic encephalopathy: a case control study using echocardiography","volume":"31","author":"Yoon","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2026030321345907400_bib14","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.3109\/14767058.2011.644365","article-title":"The assessment of time-dependent myocardial changes in infants with perinatal hypoxia","volume":"25","author":"Cetin","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2026030321345907400_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1476-7120-11-34","article-title":"Speckle tracking derived strain in infants with severe perinatal asphyxia: a comparative case control study","volume":"11","author":"Sehgal","year":"2013","journal-title":"Cardiovasc Ultrasound"},{"key":"2026030321345907400_bib16","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.ultrasmedbio.2013.03.024","article-title":"Left ventricular longitudinal strain and strain rate measured by 2-D speckle tracking echocardiography in neonates during whole-body hypothermia","volume":"39","author":"Czernik","year":"2013","journal-title":"Ultrasound Med Biol"},{"key":"2026030321345907400_bib17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.earlhumdev.2014.01.014","article-title":"The myocardial function during and after whole-body therapeutic hypothermia for hypoxic-ischemic encephalopathy, a cohort study","volume":"90","author":"Nestaas","year":"2014","journal-title":"Early Hum Dev"},{"key":"2026030321345907400_bib18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1152\/jappl.1977.42.1.56","article-title":"Dependency of hypoxic pulmonary vasoconstriction on temperature","volume":"42","author":"Benumof","year":"1977","journal-title":"J Appl Physiol"},{"key":"2026030321345907400_bib19","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jpeds.2014.01.028","article-title":"Preferential cephalic redistribution of left ventricular cardiac output during therapeutic hypothermia for perinatal hypoxic-ischemic encephalopathy","volume":"164","author":"Hochwald","year":"2014","journal-title":"J Pediatr"},{"key":"2026030321345907400_bib20","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/archpediatrics.2011.43","article-title":"Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial","volume":"165","author":"Jacobs","year":"2011","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2026030321345907400_bib21","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1542\/peds.91.3.617","article-title":"Score for Neonatal Acute Physiology: a physiologic severity index for neonatal intensive care","volume":"91","author":"Richardson","year":"1993","journal-title":"Pediatrics"},{"key":"2026030321345907400_bib22","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.echo.2011.07.014","article-title":"Targeted neonatal echocardiography in the neonatal intensive care unit: practice guidelines and recommendations for training: writing group of the American Society of Echocardiography (ASE) in collaboration with the European Association of Echocardiography (EAE) and the Association for European Pediatric Cardiologists (AEPC)","volume":"24","author":"Mertens","year":"2011","journal-title":"J Am Soc Echocardiogr"},{"key":"2026030321345907400_bib23","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jpeds.2016.11.003","article-title":"Left ventricular function in healthy term neonates during the transitional period","volume":"182","author":"Jain","year":"2017","journal-title":"J Pediatr"},{"key":"2026030321345907400_bib24","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.echo.2014.08.018","article-title":"A comprehensive echocardiographic protocol for assessing neonatal right ventricular dimensions and function in the transitional period: normative data and z scores","volume":"27","author":"Jain","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"key":"2026030321345907400_bib25","doi-asserted-by":"crossref","first-page":"H691","DOI":"10.1152\/ajpheart.00653.2002","article-title":"Echocardiographic measurement of cardiac output in rats","volume":"284","author":"Slama","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026030321345907400_bib26","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.echo.2018.04.004","article-title":"Right ventricular-pulmonary vascular interactions: an emerging role for pulmonary artery acceleration time by echocardiography in adults and children","volume":"31","author":"Levy","year":"2018","journal-title":"J Am Soc Echocardiogr"},{"key":"2026030321345907400_bib27","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jcmg.2018.09.022","article-title":"A novel noninvasive index to characterize right ventricle pulmonary arterial vascular coupling in children","volume":"12","author":"Levy","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026030321345907400_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1164\/rccm.201409-1594OC","article-title":"Early pulmonary vascular disease in preterm infants at risk for bronchopulmonary dysplasia","volume":"191","author":"Mourani","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321345907400_bib29","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch Neurol"},{"key":"2026030321345907400_bib30","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1148\/radiology.213.1.r99oc19258","article-title":"Correlation between renal vascular resistance, pulse pressure, and the resistive index in isolated perfused rabbit kidneys","volume":"213","author":"Tublin","year":"1999","journal-title":"Radiology"},{"key":"2026030321345907400_bib31","first-page":"777","article-title":"Brain magnetic resonance imaging and outcome after hypoxic ischaemic encephalopathy","volume-title":"J Matern Fetal Neonatal Med","author":"Hayes","year":"2016"},{"key":"2026030321345907400_bib32","first-page":"143","article-title":"Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems","volume":"19","author":"Barkovich","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"2026030321345907400_bib33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1542\/peds.2008-0283","article-title":"Comparison of computer tomography and magnetic resonance imaging scans on the third day of life in term newborns with neonatal encephalopathy","volume":"123","author":"Chau","year":"2009","journal-title":"Pediatrics"},{"key":"2026030321345907400_bib34","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1007\/s00134-012-2544-x","article-title":"Prospective validation of the vasoactive-inotropic score and correlation to short-term outcomes in neonates and infants after cardiothoracic surgery","volume":"38","author":"Davidson","year":"2012","journal-title":"Intensive Care Med"},{"key":"2026030321345907400_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000322006","article-title":"Systolic right ventricular function in preterm and term neonates: reference values of the tricuspid annular plane systolic excursion (TAPSE) in 258 patients and calculation of Z-score values","volume":"100","author":"Koestenberger","year":"2011","journal-title":"Neonatology"},{"key":"2026030321345907400_bib36","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/tropej\/fml053","article-title":"The correlation between myocardial function and cerebral hemodynamics in term infants with hypoxic-ischemic encephalopathy","volume":"53","author":"Liu","year":"2007","journal-title":"J Trop Pediatr"},{"key":"2026030321345907400_bib37","first-page":"457","article-title":"Adrenal haemorrhage in neonates: risk factors and diagnostic and clinical procedure [in Polish]","volume":"12","author":"Rumi\u0144ska","year":"2008","journal-title":"Med Wieku Rozwoj"},{"key":"2026030321345907400_bib38","first-page":"434","article-title":"Changes of cardiovascular regulation during rewarming in newborns undergoing whole-body hypothermia","volume":"36","author":"Koz\u00e1r","year":"2015","journal-title":"Neuroendocrinol Lett"},{"key":"2026030321345907400_bib39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jp.2010.146","article-title":"Physiologic and pharmacologic considerations for hypothermia therapy in neonates","volume":"31","author":"Zanelli","year":"2011","journal-title":"J Perinatol"},{"key":"2026030321345907400_bib40","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.3109\/14767058.2015.1077221","article-title":"Effect of persistent pulmonary hypertension on brain oxygenation in asphyxiated term newborns treated with hypothermia","volume":"29","author":"Gagnon","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2026030321345907400_bib41","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1055\/s-0038-1629900","article-title":"Cardiovascular performance during whole body hypothermia and after active rewarming and MRI patterns of brain injury","volume":"35","author":"More","year":"2018","journal-title":"Am J Perinatol"},{"key":"2026030321345907400_bib42","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/apa.13866","article-title":"Biventricular function on early echocardiograms in neonatal hypoxic-ischaemic encephalopathy","volume":"106","author":"Aggarwal","year":"2017","journal-title":"Acta Paediatr"},{"key":"2026030321345907400_bib43","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/ehjci\/jev071","article-title":"Right ventricular echocardiographic indices predict poor outcomes in infants with persistent pulmonary hypertension of the newborn","volume":"16","author":"Malowitz","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026030321345907400_bib44","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1164\/rccm.200604-547OC","article-title":"Tricuspid annular displacement predicts survival in pulmonary hypertension","volume":"174","author":"Forfia","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321345907400_bib45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1540-8175.2007.00365.x","article-title":"Right heart function and scleroderma: insights from tricuspid annular plane systolic excursion","volume":"24","author":"Lee","year":"2007","journal-title":"Echocardiography"},{"key":"2026030321345907400_bib46","first-page":"151","article-title":"Tricuspid annular plane systolic excursion (TAPSE) predicts poor outcome in patients undergoing acute pulmonary embolectomy","volume":"7","author":"Schmid","year":"2015","journal-title":"Heart Lung Vessel"},{"key":"2026030321345907400_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1047951109991314","article-title":"Longitudinal strain and strain rate by tissue Doppler are more sensitive indices than fractional shortening for assessing the reduced myocardial function in asphyxiated neonates","volume":"21","author":"Nestaas","year":"2011","journal-title":"Cardiol Young"},{"key":"2026030321345907400_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"2026030321345907400_bib49","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1017\/S104795111200011X","article-title":"Is myocardial performance index useful in differential diagnosis of moderate and severe hypoxic-ischaemic encephalopathy? A serial Doppler echocardiographic evaluation","volume":"22","author":"Karaarslan","year":"2012","journal-title":"Cardiol Young"},{"key":"2026030321345907400_bib50","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0022-3476(80)80833-X","article-title":"Ischemic papillary muscle necrosis in stressed newborn infants","volume":"96","author":"Donnelly","year":"1980","journal-title":"J Pediatr"},{"key":"2026030321345907400_bib51","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jpeds.2018.04.051","article-title":"Cardiopulmonary adaptation during first day of life in human neonates","volume":"200","author":"Jain","year":"2018","journal-title":"J Pediatr"},{"key":"2026030321345907400_bib52","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1203\/00006450-198712000-00001","article-title":"Fetal lamb ventricles respond differently to filling and arterial pressures and to in utero ventilation","volume":"22","author":"Reller","year":"1987","journal-title":"Pediatr Res"},{"key":"2026030321345907400_bib53","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1071\/RD9950451","article-title":"Ultrastructural and functional features of the developing mammalian heart: a brief overview","volume":"7","author":"Smolich","year":"1995","journal-title":"Reprod Fertil Dev"},{"key":"2026030321345907400_bib54","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.resuscitation.2011.11.008","article-title":"Protective effects of therapeutic hypothermia in post-resuscitation myocardium","volume":"83","author":"Lee","year":"2012","journal-title":"Resuscitation"},{"key":"2026030321345907400_bib55","first-page":"253","article-title":"An anatomic basis for fetal right ventricular dominance and arterial pressure sensitivity","volume":"9","author":"Pinson","year":"1987","journal-title":"J Dev Physiol"},{"key":"2026030321345907400_bib56","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41390-018-0075-z","article-title":"Application of neonatologist performed echocardiography in the assessment and management of neonatal heart failure unrelated to congenital heart disease","volume":"84","author":"Levy","year":"2018","journal-title":"Pediatr Res"},{"key":"2026030321345907400_bib57","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/cvr\/cvx160","article-title":"The overloaded right heart and ventricular interdependence","volume":"113","author":"Naeije","year":"2017","journal-title":"Cardiovasc Res"},{"key":"2026030321345907400_bib58","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.earlhumdev.2018.11.006","article-title":"Left ventricular diastolic function influences right ventricular - pulmonary vascular coupling in premature infants","volume":"128","author":"Bussmann","year":"2019","journal-title":"Early Hum Dev"},{"key":"2026030321345907400_bib59","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1055\/s-0038-1629900","article-title":"Cardiovascular associations with abnormal brain magnetic resonance imaging in neonates with hypoxic ischemic encephalopathy undergoing therapeutic hypothermia and rewarming","volume":"35","author":"More","year":"2018","journal-title":"Am J Perinatol"},{"key":"2026030321345907400_bib60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpeds.2017.12.055","article-title":"Pulmonary hypertension associated with hypoxic-ischemic encephalopathy-antecedent characteristics and comorbidities","volume":"196","author":"Lakshminrusimha","year":"2018","journal-title":"J Pediatr"},{"key":"2026030321345907400_bib61","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1152\/ajpregu.90689.2008","article-title":"Effects of acute acidemia on the fetal cardiovascular defense to acute hypoxemia","volume":"296","author":"Thakor","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2026030321345907400_bib62","first-page":"391","article-title":"Right ventricular adaptation and failure in pulmonary arterial hypertension","volume":"31","author":"Ryan","year":"2015","journal-title":"Can J Cardiol"},{"key":"2026030321345907400_bib63","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1161\/01.CIR.68.2.302","article-title":"Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique","volume":"68","author":"Kitabatake","year":"1983","journal-title":"Circulation"},{"key":"2026030321345907400_bib64","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1152\/jappl.1997.82.3.882","article-title":"Changes in regional lung mechanics and ventilation distribution after unilateral pulmonary artery occlusion","volume":"82","author":"Simon","year":"1997","journal-title":"J Appl Physiol (1985)"},{"key":"2026030321345907400_bib65","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00421-004-1235-x","article-title":"Effect of perfusate temperature on pulmonary vascular resistance and compliance by arterial and venous occlusion in the rat","volume":"93","author":"Rubini","year":"2005","journal-title":"Eur J Appl Physiol"},{"key":"2026030321345907400_bib66","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1203\/00006450-199301000-00013","article-title":"Frequent episodes of brief ischemia sensitize the fetal sheep brain to neuronal loss and induce striatal injury","volume":"33","author":"Mallard","year":"1993","journal-title":"Pediatr Res"},{"key":"2026030321345907400_bib67","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41372-019-0337-6","article-title":"The relationship between blood pressure parameters and left ventricular output in neonates","volume":"39","author":"Kharrat","year":"2019","journal-title":"J Perinatol"},{"key":"2026030321345907400_bib68","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuroimage.2013.04.072","article-title":"Near-infrared spectroscopy versus magnetic resonance imaging to study brain perfusion in newborns with hypoxic-ischemic encephalopathy treated with hypothermia","volume":"85","author":"Wintermark","year":"2014","journal-title":"Neuroimage"},{"key":"2026030321345907400_bib69","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/pr.2013.84","article-title":"Cerebral oxygenation and brain activity after perinatal asphyxia: does hypothermia change their prognostic value?","volume":"74","author":"Lemmers","year":"2013","journal-title":"Pediatr Res"},{"key":"2026030321345907400_bib70","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1542\/peds.2005-0987","article-title":"Cerebral oxygenation and electrical activity after birth asphyxia: their relation to outcome","volume":"117","author":"Toet","year":"2006","journal-title":"Pediatrics"},{"key":"2026030321345907400_bib71","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.braindev.2011.09.008","article-title":"Early predictors of short term neurodevelopmental outcome in asphyxiated cooled infants: a combined brain amplitude integrated electroencephalography and near infrared spectroscopy study","volume":"35","author":"Ancora","year":"2013","journal-title":"Brain Dev"},{"key":"2026030321345907400_bib72","doi-asserted-by":"crossref","first-page":"955","DOI":"10.7863\/jum.2008.27.6.955","article-title":"Blood flow velocities in the anterior cerebral artery and basilar artery in asphyxiated infants","volume":"27","author":"Nishimaki","year":"2008","journal-title":"J Ultrasound Med"},{"key":"2026030321345907400_bib73","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/ajh\/hpu185","article-title":"Doppler indexes of left ventricular systolic and diastolic flow and central pulse pressure in relation to renal resistive index","volume":"28","author":"Kuznetsova","year":"2015","journal-title":"Am J Hypertens"},{"key":"2026030321345907400_bib74","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.earlhumdev.2017.07.008","article-title":"Cerebral regional oxygen saturation trends in infants with hypoxic-ischemic encephalopathy","volume":"113","author":"Jain","year":"2017","journal-title":"Early Hum Dev"},{"key":"2026030321345907400_bib75","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.earlhumdev.2006.06.005","article-title":"Cardiovascular impact of dobutamine in neonates with myocardial dysfunction","volume":"83","author":"Robel-Tillig","year":"2007","journal-title":"Early Hum Dev"},{"key":"2026030321345907400_bib76","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/cc13707","article-title":"Pharmacokinetics, hemodynamic and metabolic effects of epinephrine to prevent post-operative low cardiac output syndrome in children","volume":"18","author":"Oualha","year":"2014","journal-title":"Crit Care"},{"key":"2026030321345907400_bib77","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.echo.2013.06.021","article-title":"Effects of therapeutic hypothermia on left ventricular function assessed by ultrasound imaging","volume":"26","author":"Espinoza","year":"2013","journal-title":"J Am Soc Echocardiogr"},{"key":"2026030321345907400_bib78","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1080\/14767058.2017.1344633","article-title":"Effect of therapeutic hypothermia on myocardial dysfunction in term neonates with perinatal asphyxia: a randomized controlled trial","volume":"31","author":"Rakesh","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2026030321345907400_bib79","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s00246-010-9661-5","article-title":"Myocardial performance in asphyxiated full-term infants assessed by Doppler tissue imaging","volume":"31","author":"Matter","year":"2010","journal-title":"Pediatr Cardiol"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/200\/10\/1294\/67170632\/ajrccm_200_10_1294.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/200\/10\/1294\/67170632\/ajrccm_200_10_1294.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:35:17Z","timestamp":1772591717000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/200\/10\/1294\/8496985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":79,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,11,15]]},"published-print":{"date-parts":[[2019,11,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201903-0583oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"2019-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}