{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:50:07Z","timestamp":1780087807360,"version":"3.54.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":2254,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>When stereotactic ablative radiotherapy is an option for patients with non\u2013small cell lung cancer (NSCLC), distinguishing between N0, N1, and N2 or N3 (N2|3) disease is important.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop a prediction model for estimating the probability of N0, N1, and N2|3 disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with clinical-radiographic stage T1 to T3, N0 to N3, and M0 NSCLC who underwent endobronchial ultrasound\u2013guided staging from a single center were included. Multivariate ordinal logistic regression analysis was used to predict the presence of N0, N1, or N2|3 disease. Temporal validation used consecutive patients from 3 years later at the same center. External validation used three other hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>In the model development cohort (n\u2009=\u2009633), younger age, central location, adenocarcinoma, and higher positron emission tomography\u2013computed tomography nodal stage were associated with a higher probability of having advanced nodal disease. Areas under the receiver operating characteristic curve (AUCs) were 0.84 and 0.86 for predicting N1 or higher (vs. N0) disease and N2|3 (vs. N0 or N1) disease, respectively. Model fit was acceptable (Hosmer-Lemeshow, P\u2009=\u20090.960; Brier score, 0.36). In the temporal validation cohort (n\u2009=\u2009473), AUCs were 0.86 and 0.88. Model fit was acceptable (Hosmer-Lemeshow, P\u2009=\u20090.172; Brier score, 0.30). In the external validation cohort (n\u2009=\u2009722), AUCs were 0.86 and 0.88 but required calibration (Hosmer-Lemeshow, P\u2009&amp;lt;\u20090.001; Brier score, 0.38). Calibration using the general calibration method resulted in acceptable model fit (Hosmer-Lemeshow, P\u2009=\u20090.094; Brier score, 0.34).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This prediction model can estimate the probability of N0, N1, and N2|3 disease in patients with NSCLC. The model has the potential to facilitate decision-making in patients with NSCLC when stereotactic ablative radiotherapy is an option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201904-0831oc","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T17:10:39Z","timestamp":1569949839000},"page":"212-223","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":31,"title":["A Prediction Model to Help with Oncologic Mediastinal Evaluation for Radiation: HOMER"],"prefix":"10.1093","volume":"201","author":[{"given":"Gabriela","family":"Martinez-Zayas","sequence":"first","affiliation":[{"name":"Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey, Mexico"},{"name":"Department of Pulmonary Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco A.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Simoff","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lonny","family":"Yarmus","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Molina","sequence":"additional","affiliation":[{"name":"Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey, Mexico"},{"name":"Department of Pulmonary Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University Hospitals, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Feller-Kopman","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala-Eddin S.","family":"Sagar","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gildea","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Labib G.","family":"Debiane","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horiana B.","family":"Grosu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto F.","family":"Casal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad H.","family":"Arain","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Eapen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila Z.","family":"Noor","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Baghaie","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhee","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-5552","authenticated-orcid":false,"given":"David E.","family":"Ost","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"2026030321445673800_bib1","first-page":"e211S","article-title":"Methods for staging non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed. 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