{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:32:24Z","timestamp":1790937144294,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Platelets are generated in the capillaries of the lung, control hemostasis, and display immunological functions. Tuberculosis primarily affects the lung, and patients show platelet changes and hemoptysis. A role of platelets in immunopathology of pulmonary tuberculosis requires careful assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify the dynamics and interaction partners of platelets in the respiratory tissue and establish their impact on the outcome of pulmonary tuberculosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Investigations were primarily performed in murine models of primary progressive pulmonary tuberculosis, by analysis of mouse strains with variable susceptibility to Mycobacterium tuberculosis infection using platelet depletion and delivery of antiplatelet drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Platelets were present at the site of infection and formed aggregates with different myeloid subsets during experimental tuberculosis. Such aggregates were also detected in patients with tuberculosis. Platelets were detrimental during the early phase of infection, and this effect was uncoupled from their canonical activation. Platelets left lung cell dynamics and patterns of antimycobacterial T-cell responses unchanged but hampered antimicrobial defense by restricting production of reactive oxygen species in lung-residing myeloid cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Platelets are detrimental in primary progressive pulmonary tuberculosis, orchestrate lung immunity by modulating innate immune responsiveness, and may be amenable to new interventions for this deadly disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201910-2063oc","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T14:20:00Z","timestamp":1589811600000},"page":"730-744","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":20,"title":["Platelets Restrict the Oxidative Burst in Phagocytes and Facilitate Primary Progressive Tuberculosis"],"prefix":"10.1093","volume":"202","author":[{"given":"Lisa","family":"Scheuermann","sequence":"first","affiliation":[{"name":"Immunology Department and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Pei","sequence":"additional","affiliation":[{"name":"Immunology Department and"},{"name":"Institute of Immunology, Friedrich-Loeffler-Institut, Greifswald \u2013 Insel Riems, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Domaszewska","sequence":"additional","affiliation":[{"name":"Immunology Department and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Zyla","sequence":"additional","affiliation":[{"name":"Immunology Department and"},{"name":"Department of Data Science and Engineering, Silesian University of Technology, Gliwice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Oberbeck-M\u00fcller","sequence":"additional","affiliation":[{"name":"Immunology Department and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Bandermann","sequence":"additional","affiliation":[{"name":"Immunology Department and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Feng","sequence":"additional","affiliation":[{"name":"Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Sebastian","family":"Ruiz Moreno","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian","family":"Opitz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Infectious Diseases and Pulmonary Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Mollenkopf","sequence":"additional","affiliation":[{"name":"Microarray Core Facility, Max Planck Institute for Infection Biology, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H. E.","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Immunology Department and"},{"name":"Hagler Institute for Advanced Study at Texas A&M University, College Station, Texas; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1739-749X","authenticated-orcid":false,"given":"Anca","family":"Dorhoi","sequence":"additional","affiliation":[{"name":"Immunology Department and"},{"name":"Institute of Immunology, Friedrich-Loeffler-Institut, Greifswald \u2013 Insel Riems, Germany"},{"name":"Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"key":"2026030321491004300_bib1","article-title":"Global tuberculosis report 2019","author":"World Health Organization","year":"2019"},{"key":"2026030321491004300_bib2","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1002\/eji.201545493","article-title":"Versatile myeloid cell subsets contribute to tuberculosis-associated inflammation","volume":"45","author":"Dorhoi","year":"2015","journal-title":"Eur J Immunol"},{"key":"2026030321491004300_bib3","doi-asserted-by":"crossref","first-page":"a018549","DOI":"10.1101\/cshperspect.a018549","article-title":"Manipulation of the mononuclear phagocyte system by Mycobacterium tuberculosis","volume":"4","author":"Lugo-Villarino","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2026030321491004300_bib4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2013.03.022","article-title":"TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species","volume":"153","author":"Roca","year":"2013","journal-title":"Cell"},{"key":"2026030321491004300_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature21706","article-title":"The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors","volume":"544","author":"Lefran\u00e7ais","year":"2017","journal-title":"Nature"},{"key":"2026030321491004300_bib6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1164\/rccm.201710-2102OC","article-title":"Platelets regulate pulmonary inflammation and tissue destruction in tuberculosis","volume":"198","author":"Fox","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321491004300_bib7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1128\/CVI.00493-10","article-title":"Elevated serum levels of CCL17 correlate with increased peripheral blood platelet count in patients with active tuberculosis in China","volume":"18","author":"Feng","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"2026030321491004300_bib8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrmicro3269","article-title":"Platelets: at the nexus of antimicrobial defence","volume":"12","author":"Yeaman","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"2026030321491004300_bib9","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1084\/jem.20170879","article-title":"Platelets as autonomous drones for hemostatic and immune surveillance","volume":"214","author":"Li","year":"2017","journal-title":"J Exp Med"},{"key":"2026030321491004300_bib10","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1093\/infdis\/jiu355","article-title":"Platelets direct monocyte differentiation into epithelioid-like multinucleated giant foam cells with suppressive capacity upon mycobacterial stimulation","volume":"210","author":"Feng","year":"2014","journal-title":"J Infect Dis"},{"key":"2026030321491004300_bib11","author":"Scheuermann"},{"key":"2026030321491004300_bib12","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1164\/rccm.201405-0828OC","article-title":"Lung-residing myeloid-derived suppressors display dual functionality in murine pulmonary tuberculosis","volume":"190","author":"Knaul","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321491004300_bib13","article-title":"Inhibition of host Lactate dehydrogenase A by a small-molecule limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid [preprint]","author":"Krishnamoorthy","year":"2019","journal-title":"bioRxiv"},{"key":"2026030321491004300_bib14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature13684","article-title":"AhR sensing of bacterial pigments regulates antibacterial defence","volume":"512","author":"Moura-Alves","year":"2014","journal-title":"Nature"},{"key":"2026030321491004300_bib15","first-page":"e1005408","article-title":"IFNs modify the proteome of legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid","volume-title":"PLoS Pathog","author":"Naujoks","year":"2016"},{"key":"2026030321491004300_bib16","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1002\/eji.201344219","article-title":"Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics","volume":"44","author":"Dorhoi","year":"2014","journal-title":"Eur J Immunol"},{"key":"2026030321491004300_bib17","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1182\/blood.V77.10.2207.2207","article-title":"Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein IIIa in patients with chronic immune thrombocytopenic purpura","volume":"77","author":"Fujisawa","year":"1991","journal-title":"Blood"},{"key":"2026030321491004300_bib18","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1038\/ncomms3657","article-title":"Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway","volume":"4","author":"Xiang","year":"2013","journal-title":"Nat Commun"},{"key":"2026030321491004300_bib19","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1182\/blood-2014-12-617159","article-title":"Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice","volume":"126","author":"Gros","year":"2015","journal-title":"Blood"},{"key":"2026030321491004300_bib20","doi-asserted-by":"crossref","first-page":"a018556","DOI":"10.1101\/cshperspect.a018556","article-title":"Mouse model of tuberculosis","volume":"5","author":"Cooper","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2026030321491004300_bib21","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1242\/dmm.019570","article-title":"Presence of multiple lesion types with vastly different microenvironments in C3HeB\/FeJ mice following aerosol infection with Mycobacterium tuberculosis","volume":"8","author":"Irwin","year":"2015","journal-title":"Dis Model Mech"},{"key":"2026030321491004300_bib22","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1172\/JCI72030","article-title":"CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis","volume":"124","author":"Nouailles","year":"2014","journal-title":"J Clin Invest"},{"key":"2026030321491004300_bib23","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-immunol-032712-095939","article-title":"The immune response in tuberculosis","volume":"31","author":"O\u2019Garra","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"2026030321491004300_bib24","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1093\/jac\/dku166","article-title":"Simvastatin increases the in vivo activity of the first-line tuberculosis regimen","volume":"69","author":"Skerry","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"2026030321491004300_bib25","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1093\/nar\/12.4.2137","article-title":"Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents","volume":"12","author":"Kasai","year":"1984","journal-title":"Nucleic Acids Res"},{"key":"2026030321491004300_bib26","doi-asserted-by":"crossref","first-page":"e1001230","DOI":"10.1371\/journal.ppat.1001230","article-title":"Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling","volume":"6","author":"Shin","year":"2010","journal-title":"PLoS Pathog"},{"key":"2026030321491004300_bib27","first-page":"eaaw6635","article-title":"Targeting redox heterogeneity to counteract drug tolerance in replicating Mycobacterium tuberculosis","volume-title":"Sci Transl Med","author":"Mishra","year":"2019"},{"key":"2026030321491004300_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.immuni.2014.12.020","article-title":"Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection","volume":"42","author":"Bl\u00e9riot","year":"2015","journal-title":"Immunity"},{"key":"2026030321491004300_bib29","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.immuni.2017.07.018","article-title":"A liver capsular network of monocyte-derived macrophages restricts hepatic dissemination of intraperitoneal bacteria by neutrophil recruitment","volume":"47","author":"Sierro","year":"2017","journal-title":"Immunity"},{"key":"2026030321491004300_bib30","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20172020","article-title":"Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny","volume":"215","author":"Huang","year":"2018","journal-title":"J Exp Med"},{"key":"2026030321491004300_bib31","doi-asserted-by":"crossref","first-page":"12094","DOI":"10.1038\/s41598-017-11812-x","article-title":"Concordant and discordant gene expression patterns in mouse strains identify best-fit animal model for human tuberculosis","volume":"7","author":"Domaszewska","year":"2017","journal-title":"Sci Rep"},{"key":"2026030321491004300_bib32","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1164\/rccm.201406-1031OC","article-title":"Platelet activation and aggregation promote lung inflammation and influenza virus pathogenesis","volume":"191","author":"L\u00ea","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321491004300_bib33","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.cell.2017.11.001","article-title":"Migrating platelets are mechano-scavengers that collect and bundle bacteria","volume":"171","author":"Gaertner","year":"2017","journal-title":"Cell"},{"key":"2026030321491004300_bib34","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/infdis\/jiz110","article-title":"Thrombocyte inhibition restores protective immunity to mycobacterial infection in zebrafish","volume":"220","author":"Hortle","year":"2019","journal-title":"J Infect Dis"},{"key":"2026030321491004300_bib35","first-page":"1234","article-title":"Neutrophils scan for activated platelets to initiate inflammation","volume-title":"Science","author":"Sreeramkumar","year":"2014"},{"key":"2026030321491004300_bib36","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1182\/blood-2005-03-0916","article-title":"Platelets express functional toll-like receptor-4","volume":"106","author":"Andonegui","year":"2005","journal-title":"Blood"},{"key":"2026030321491004300_bib37","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1097\/CCM.0000000000000853","article-title":"Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia","volume":"43","author":"van den Boogaard","year":"2015","journal-title":"Crit Care Med"},{"key":"2026030321491004300_bib38","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tube.2018.05.002","article-title":"Platelet-monocyte interaction in Mycobacterium tuberculosis infection","volume":"111","author":"Kullaya","year":"2018","journal-title":"Tuberculosis (Edinb)"},{"key":"2026030321491004300_bib39","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.cell.2015.03.005","article-title":"Immunosurveillance of the liver by intravascular effector CD8(+) T cells","volume":"161","author":"Guidotti","year":"2015","journal-title":"Cell"},{"key":"2026030321491004300_bib40","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1186\/s13075-014-0478-0","article-title":"Platelets induce a proinflammatory phenotype in monocytes via the CD147 pathway in rheumatoid arthritis","volume":"16","author":"Rong","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"2026030321491004300_bib41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000444807","article-title":"Platelet interaction with innate immune cells","volume":"43","author":"Kral","year":"2016","journal-title":"Transfus Med Hemother"},{"key":"2026030321491004300_bib42","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1182\/blood-2017-06-788067","article-title":"Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria","volume":"131","author":"Claushuis","year":"2018","journal-title":"Blood"},{"key":"2026030321491004300_bib43","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1182\/blood-2004-06-2206","article-title":"Platelet depletion by anti-CD41 (alphaIIb) mAb injection early but not late in the course of disease protects against Plasmodium berghei pathogenesis by altering the levels of pathogenic cytokines","volume":"105","author":"van der Heyde","year":"2005","journal-title":"Blood"},{"key":"2026030321491004300_bib44","doi-asserted-by":"crossref","first-page":"e22028","DOI":"10.7554\/eLife.22028","article-title":"Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells","volume":"6","author":"Mahamed","year":"2017","journal-title":"eLife"},{"key":"2026030321491004300_bib45","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2011.06.033","article-title":"Cross talk between mitochondria and NADPH oxidases","volume":"51","author":"Dikalov","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"2026030321491004300_bib46","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1084\/jem.20151876","article-title":"Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus","volume":"213","author":"Caielli","year":"2016","journal-title":"J Exp Med"},{"key":"2026030321491004300_bib47","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm.4027","article-title":"Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease","volume":"22","author":"Lood","year":"2016","journal-title":"Nat Med"},{"key":"2026030321491004300_bib48","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nm.3813","article-title":"A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis","volume":"21","author":"Dey","year":"2015","journal-title":"Nat Med"},{"key":"2026030321491004300_bib49","doi-asserted-by":"crossref","first-page":"E8711","DOI":"10.1073\/pnas.1707792114","article-title":"Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA","volume":"114","author":"K\u00f6ster","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030321491004300_bib50","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.chom.2012.07.009","article-title":"Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages","volume":"12","author":"Yang","year":"2012","journal-title":"Cell Host Microbe"},{"key":"2026030321491004300_bib51","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.chom.2017.09.003","article-title":"M. tuberculosis-induced necrosis of infected neutrophils promotes bacterial growth following phagocytosis by macrophages","volume":"22","author":"Dallenga","year":"2017","journal-title":"Cell Host Microbe"},{"key":"2026030321491004300_bib52","doi-asserted-by":"crossref","first-page":"eaaw6693","DOI":"10.1101\/520791","article-title":"Alveolar macrophages generate a non-canonical NRF2-driven transcriptional response to Mycobacterium tuberculosis in vivo","volume-title":"Sci Immunol","author":"Rothchild","year":"2019"},{"key":"2026030321491004300_bib53","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.celrep.2019.12.033","article-title":"Dual RNA-Seq of Mtb-infected macrophages in vivo reveals ontologically distinct host-pathogen interactions","volume":"30","author":"Pisu","year":"2020","journal-title":"Cell Rep"},{"key":"2026030321491004300_bib54","first-page":"e1006874","article-title":"Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-\u03b3\/HIF-1\u03b1 signaling and supports host defense","volume-title":"PLoS Pathog","author":"Knight","year":"2018"},{"key":"2026030321491004300_bib55","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1080\/15548627.2017.1371394","article-title":"Recycling the danger via lipid droplet biogenesis after autophagy","volume":"13","author":"Li","year":"2017","journal-title":"Autophagy"},{"key":"2026030321491004300_bib56","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.celrep.2014.08.056","article-title":"Fatty acid uptake and lipid storage induced by HIF-1\u03b1 contribute to cell growth and survival after hypoxia-reoxygenation","volume":"9","author":"Bensaad","year":"2014","journal-title":"Cell Rep"},{"key":"2026030321491004300_bib57","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.4049\/jimmunol.1800202","article-title":"The phagocyte oxidase controls tolerance to Mycobacterium tuberculosis infection","volume":"201","author":"Olive","year":"2018","journal-title":"J Immunol"},{"key":"2026030321491004300_bib58","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4161\/15548627.2014.984277","article-title":"V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation","volume":"11","author":"Florey","year":"2015","journal-title":"Autophagy"},{"key":"2026030321491004300_bib59","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/s41467-018-03225-9","article-title":"Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype","volume":"9","author":"Chen","year":"2018","journal-title":"Nat Commun"},{"key":"2026030321491004300_bib60","first-page":"813","article-title":"Infection-induced vascular permeability aids mycobacterial growth","volume":"215","author":"Oehlers","year":"2017","journal-title":"J Infect Dis"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/202\/5\/730\/67176927\/ajrccm_202_5_730.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/202\/5\/730\/67176927\/ajrccm_202_5_730.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:49:22Z","timestamp":1772592562000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/202\/5\/730\/8495470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":60,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,9,1]]},"published-print":{"date-parts":[[2020,9,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201910-2063oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9]]},"published":{"date-parts":[[2020,9,1]]},"assertion":[{"value":"2019-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}