{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:21:41Z","timestamp":1790266901720,"version":"4.1.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>A subpopulation of B cells (age-associated B cells [ABCs]) is increased in mice and humans with infections or autoimmune diseases. Because depletion of these cells might be valuable in patients with certain lung diseases, the goal was to find out if ABC-like cells were at elevated levels in such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To measure ABC-like cell percentages in patients with lung granulomatous diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Peripheral blood and BAL cells from patients with sarcoidosis, beryllium sensitivity, or hypersensitivity pneumonitis and healthy subjects were analyzed for the percentage of B cells that were ABC-like, defined by expression of CD11c, low levels of CD21, FcRL 1\u20135 (Fc receptor\u2013like protein 1\u20135) expression, and, in some cases, T-bet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>ABC-like cells in blood were at low percentages in healthy subjects and higher percentages in patients with sarcoidosis as well as at high percentages among BAL cells of patients with sarcoidosis, beryllium disease, and hypersensitivity pneumonitis. Treatment of patients with sarcoidosis led to reduced percentages of ABC-like cells in blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased levels of ABC-like cells in patients with sarcoidosis may be useful in diagnosis. The increase in percentage of ABC-like cells in patients with lung granulomatous diseases and decrease in treated patients suggests that depletion of these cells may be valuable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201911-2151oc","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T12:32:12Z","timestamp":1591360332000},"page":"1013-1023","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":30,"title":["Age-associated B Cells Appear in Patients with Granulomatous Lung Diseases"],"prefix":"10.1093","volume":"202","author":[{"given":"Swati","family":"Phalke","sequence":"first","affiliation":[{"name":"Department of Biomedical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Aviszus","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira","family":"Rubtsova","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly","family":"Rubtsov","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briana","family":"Barkes","sequence":"additional","affiliation":[{"name":"Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Powers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Warner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Crooks","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research"},{"name":"Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado; and"},{"name":"Division of Biostatistics and Bioinformatics, National Jewish Health, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Kappler","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research"},{"name":"Department of Immunology and Microbiology, University Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evans R.","family":"Fern\u00e1ndez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7296-8975","authenticated-orcid":false,"given":"Nabeel","family":"Hamzeh","sequence":"additional","affiliation":[{"name":"Department of Medicine, and"},{"name":"Department of Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Marrack","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research"},{"name":"Department of Immunology and Microbiology, University Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"2026030321494662900_bib1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s10875-009-9351-3","article-title":"Frequency of Treg cells is reduced in CVID patients with autoimmunity and splenomegaly and is associated with expanded CD21lo B lymphocytes","volume":"30","author":"Arumugakani","year":"2010","journal-title":"J Clin Immunol"},{"key":"2026030321494662900_bib2","doi-asserted-by":"crossref","first-page":"e88782","DOI":"10.1172\/jci.insight.88782","article-title":"Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy","volume":"1","author":"Ferre","year":"2016","journal-title":"JCI Insight"},{"key":"2026030321494662900_bib3","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.jaip.2019.04.011","article-title":"Clinical, immunologic, and molecular spectrum of patients with lps-responsive beige-like anchor protein deficiency: a systematic review","volume":"7","author":"Habibi","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2026030321494662900_bib4","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1182\/blood-2011-01-330530","article-title":"A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice","volume":"118","author":"Hao","year":"2011","journal-title":"Blood"},{"key":"2026030321494662900_bib5","doi-asserted-by":"crossref","first-page":"19436","DOI":"10.1073\/pnas.0609515103","article-title":"Two overrepresented B cell populations in HIV-infected individuals undergo apoptosis by different mechanisms","volume":"103","author":"Ho","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030321494662900_bib6","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1182\/blood-2009-09-243071","article-title":"Complement receptor 2\/CD21- human naive B cells contain mostly autoreactive unresponsive clones","volume":"115","author":"Isnardi","year":"2010","journal-title":"Blood"},{"key":"2026030321494662900_bib7","first-page":"179","article-title":"Defects of b-cell terminal differentiation in patients with type-1 kabuki syndrome","volume-title":"J Allergy Clin Immunol","author":"Lindsley","year":"2016"},{"key":"2026030321494662900_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fimmu.2011.00077","article-title":"Exploiting human memory B cell heterogeneity for improved vaccine efficacy","volume":"2","author":"Pauli","year":"2011","journal-title":"Front Immunol"},{"key":"2026030321494662900_bib9","doi-asserted-by":"crossref","first-page":"13451","DOI":"10.1073\/pnas.0901984106","article-title":"Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells","volume":"106","author":"Rakhmanov","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030321494662900_bib10","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1182\/blood-2011-01-331462","article-title":"Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c\u207a B-cell population is important for the development of autoimmunity","volume":"118","author":"Rubtsov","year":"2011","journal-title":"Blood"},{"key":"2026030321494662900_bib11","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1078\/0171-2985-00198","article-title":"Expansion of CD19(hi)CD21(lo\/neg) B cells in common variable immunodeficiency (CVID) patients with autoimmune cytopenia","volume":"206","author":"Warnatz","year":"2002","journal-title":"Immunobiology"},{"key":"2026030321494662900_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cellimm.2017.07.006","article-title":"CD11c+ T-bet+ memory B cells: immune maintenance during chronic infection and inflammation?","volume":"321","author":"Winslow","year":"2017","journal-title":"Cell Immunol"},{"key":"2026030321494662900_bib13","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.4049\/jimmunol.1600522","article-title":"Cutting edge: il-4, il-21, and ifn-gamma interact to govern t-bet and cd11c expression in tlr-activated b cells","volume":"197","author":"Naradikian","year":"2016","journal-title":"J Immunol"},{"key":"2026030321494662900_bib14","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1172\/JCI91250","article-title":"B cells expressing the transcription factor T-bet drive lupus-like autoimmunity","volume":"127","author":"Rubtsova","year":"2017","journal-title":"J Clin Invest"},{"key":"2026030321494662900_bib15","first-page":"1070","article-title":"T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution","volume":"90","author":"J\u00f6hrens","year":"2005","journal-title":"Haematologica"},{"key":"2026030321494662900_bib16","doi-asserted-by":"crossref","first-page":"eaai8153","DOI":"10.1126\/sciimmunol.aai8153","article-title":"Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation","volume":"2","author":"Lau","year":"2017","journal-title":"Sci Immunol"},{"key":"2026030321494662900_bib17","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.4049\/jimmunol.1501027","article-title":"Fc receptor-like 5 expression distinguishes two distinct subsets of human circulating tissue-like memory b cells","volume":"196","author":"Li","year":"2016","journal-title":"J Immunol"},{"key":"2026030321494662900_bib18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.clim.2018.02.003","article-title":"Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5","volume":"193","author":"Nipper","year":"2018","journal-title":"Clin Immunol"},{"key":"2026030321494662900_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cellimm.2017.07.003","article-title":"Atypical memory B cells in human chronic infectious diseases: an interim report","volume":"321","author":"Portugal","year":"2017","journal-title":"Cell Immunol"},{"key":"2026030321494662900_bib20","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.immuni.2020.03.020","article-title":"The transcription factor t-bet resolves memory b cell subsets with distinct tissue distributions and antibody specificities in mice and humans","volume":"52","author":"Johnson","year":"2020","journal-title":"Immunity"},{"key":"2026030321494662900_bib21","doi-asserted-by":"crossref","first-page":"e41641","DOI":"10.7554\/eLife.41641","article-title":"IFN\u03b3 induces epigenetic programming of human T-bethi B cells and promotes TLR7\/8 and IL-21 induced differentiation","volume":"8","author":"Zumaquero","year":"2019","journal-title":"eLife"},{"key":"2026030321494662900_bib22","doi-asserted-by":"crossref","first-page":"e0166322","DOI":"10.1371\/journal.pone.0166322","article-title":"T cell production of ifngamma in response to tlr7\/il-12 stimulates optimal b cell responses to viruses","volume":"11","author":"Rubtsova","year":"2016","journal-title":"PLoS One"},{"key":"2026030321494662900_bib23","doi-asserted-by":"crossref","first-page":"E3216","DOI":"10.1073\/pnas.1312348110","article-title":"T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance","volume":"110","author":"Rubtsova","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030321494662900_bib24","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.4049\/jimmunol.181.2.1375","article-title":"CD11c expression identifies a population of extrafollicular antigen-specific splenic plasmablasts responsible for CD4 T-independent antibody responses during intracellular bacterial infection","volume":"181","author":"Racine","year":"2008","journal-title":"J Immunol"},{"key":"2026030321494662900_bib25","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.4049\/jimmunol.159.3.1557","article-title":"Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL\/lpr mice","volume":"159","author":"Takahashi","year":"1997","journal-title":"J Immunol"},{"key":"2026030321494662900_bib26","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1182\/blood-2014-08-593202","article-title":"Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency","volume":"125","author":"Stepensky","year":"2015","journal-title":"Blood"},{"key":"2026030321494662900_bib27","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/eji.201747127","article-title":"Age-associated B cells expanded in autoimmune mice are memory cells sharing H-CDR3-selected repertoires","volume":"48","author":"Aranburu","year":"2018","journal-title":"Eur J Immunol"},{"key":"2026030321494662900_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.coi.2019.01.002","article-title":"T-bet+ B cells: a common denominator in protective and autoreactive antibody responses?","volume":"57","author":"Myles","year":"2019","journal-title":"Curr Opin Immunol"},{"key":"2026030321494662900_bib29","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1089\/dna.2016.3304","article-title":"T-bet-expressing b cells are positively associated with crohn\u2019s disease activity and support th1 inflammation","volume":"35","author":"Wang","year":"2016","journal-title":"DNA Cell Biol"},{"key":"2026030321494662900_bib30","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/art.39559","article-title":"Enhanced tyrosine phosphatase activity underlies dysregulated b cell receptor signaling and promotes survival of human lupus b cells","volume":"68","author":"Fleischer","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2026030321494662900_bib31","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1038\/s41467-018-03750-7","article-title":"IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun"},{"key":"2026030321494662900_bib32","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.4049\/jimmunol.1502448","article-title":"Age-associated b cells with proinflammatory characteristics are expanded in a proportion of multiple sclerosis patients","volume":"197","author":"Claes","year":"2016","journal-title":"J Immunol"},{"key":"2026030321494662900_bib33","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jhep.2019.06.029","article-title":"TLR9 signalling in HCV-associated atypical memory B cells triggers Th1 and rheumatoid factor autoantibody responses","volume":"71","author":"Comarmond","year":"2019","journal-title":"J Hepatol"},{"key":"2026030321494662900_bib34","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/art.38222","article-title":"CD21(-\/low) marginal zone B cells highly express Fc receptor-like 5 protein and are killed by anti-Fc receptor-like 5 immunotoxins in hepatitis C virus-associated mixed cryoglobulinemia vasculitis","volume":"66","author":"Terrier","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"2026030321494662900_bib35","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/eji.201142313","article-title":"Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21 low cells overexpressing Stra13","volume":"42","author":"Visentini","year":"2012","journal-title":"Eur J Immunol"},{"key":"2026030321494662900_bib36","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.4049\/jimmunol.1303214","article-title":"Human regulatory B cells combine phenotypic and genetic hallmarks with a distinct differentiation fate","volume":"193","author":"Lin","year":"2014","journal-title":"J Immunol"},{"key":"2026030321494662900_bib37","first-page":"511","article-title":"Rituximab as a treatment alternative in sarcoidosis","volume-title":"Joint Bone Spine","author":"Belkhou","year":"2008"},{"key":"2026030321494662900_bib38","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1212\/WNL.0b013e3181ec7ff9","article-title":"A case of neurosarcoidosis successfully treated with rituximab","volume":"75","author":"Bomprezzi","year":"2010","journal-title":"Neurology"},{"key":"2026030321494662900_bib39","first-page":"82","article-title":"Relapse of severe sarcoidosis with an uncommon peritoneal location after tnfalpha blockade. Efficacy of rituximab, report of a single case","volume-title":"Joint Bone Spine","author":"Dasilva","year":"2010"},{"key":"2026030321494662900_bib40","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1164\/rccm.201407-1341OC","article-title":"Proteomic profiling reveals autoimmune targets in sarcoidosis","volume":"191","author":"H\u00e4ggmark","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321494662900_bib41","doi-asserted-by":"crossref","first-page":"e43588","DOI":"10.1371\/journal.pone.0043588","article-title":"Active chronic sarcoidosis is characterized by increased transitional blood B cells, increased IL-10-producing regulatory B cells and high BAFF levels","volume":"7","author":"Saussine","year":"2012","journal-title":"PLoS One"},{"key":"2026030321494662900_bib42","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1164\/rccm.201206-1024OC","article-title":"Perigranuloma localization and abnormal maturation of B cells: emerging key players in sarcoidosis?","volume":"187","author":"Kamphuis","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321494662900_bib43","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/0-387-46530-8_14","article-title":"Fc receptor-like proteins (FCRL): immunomodulators of B cell function","volume":"596","author":"Ehrhardt","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"2026030321494662900_bib44","doi-asserted-by":"crossref","first-page":"9770","DOI":"10.1073\/pnas.0703354104","article-title":"Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment","volume":"104","author":"Haga","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030321494662900_bib45","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.4049\/jimmunol.1002305","article-title":"FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells","volume":"185","author":"Jackson","year":"2010","journal-title":"J Immunol"},{"key":"2026030321494662900_bib46","doi-asserted-by":"crossref","first-page":"15296","DOI":"10.1038\/s41598-018-33719-x","article-title":"HBV induces inhibitory FcRL receptor on B cells and dysregulates B cell-T follicular helper cell axis","volume":"8","author":"Poonia","year":"2018","journal-title":"Sci Rep"},{"key":"2026030321494662900_bib47","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cellimm.2017.05.008","article-title":"Role of CD11c+ T-bet+ B cells in human health and disease","volume":"321","author":"Karnell","year":"2017","journal-title":"Cell Immunol"},{"key":"2026030321494662900_bib48","doi-asserted-by":"crossref","first-page":"e39800","DOI":"10.7554\/eLife.39800","article-title":"Plasmodium-specific atypical memory B cells are short-lived activated B cells","volume":"7","author":"P\u00e9rez-Mazliah","year":"2018","journal-title":"eLife"},{"key":"2026030321494662900_bib49","first-page":"736","article-title":"Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), The European Respiratory Society (ERS) and The World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999","volume":"160","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321494662900_bib50","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1164\/rccm.201409-1722ST","article-title":"An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease","volume":"190","author":"Balmes","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321494662900_bib51","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias","volume":"188","author":"Travis","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321494662900_bib52","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1164\/rccm.201202-0320ST","article-title":"An official American Thoracic Society clinical practice guideline: the clinical utility of bronchoalveolar lavage cellular analysis in interstitial lung disease","volume":"185","author":"Meyer","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321494662900_bib53","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-21706-2","volume-title":"Modern applied statistics with s.","author":"Venables","year":"2002"},{"key":"2026030321494662900_bib54","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/j.ajpath.2013.02.042","article-title":"CD19 expression in B cells regulates atopic dermatitis in a mouse model","volume":"182","author":"Yanaba","year":"2013","journal-title":"Am J Pathol"},{"key":"2026030321494662900_bib55","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/jvh.12659","article-title":"Hepatitis C viraemia reversibly maintains subset of antigen-specific T-bet+ tissue-like memory B cells","volume":"24","author":"Chang","year":"2017","journal-title":"J Viral Hepat"},{"key":"2026030321494662900_bib56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1189\/jlb.0211096","article-title":"Fc receptor-like 5 promotes B cell proliferation and drives the development of cells displaying switched isotypes","volume":"91","author":"Dement-Brown","year":"2012","journal-title":"J Leukoc Biol"},{"key":"2026030321494662900_bib57","first-page":"89","article-title":"Immunoregulatory roles for fc receptor-like molecules","volume":"350","author":"Ehrhardt","year":"2011","journal-title":"Curr Top Microbiol Immunol"},{"key":"2026030321494662900_bib58","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/14728222.2018.1472768","article-title":"Update on Fc receptor-like (FCRL) family: new immunoregulatory players in health and diseases","volume":"22","author":"Rostamzadeh","year":"2018","journal-title":"Expert Opin Ther Targets"},{"key":"2026030321494662900_bib59","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1365-2265.2010.03843.x","article-title":"Association of Fc receptor-like 5 (FCRL5) with Graves\u2019 disease is secondary to the effect of FCRL3","volume":"73","author":"Simmonds","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2026030321494662900_bib60","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1182\/blood-2004-06-2344","article-title":"FcRH1: an activation coreceptor on human B cells","volume":"105","author":"Leu","year":"2005","journal-title":"Blood"},{"key":"2026030321494662900_bib61","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1590\/S0100-879X2012007500130","article-title":"Overexpression of fFc receptor-like 1 associated with B-cell activation during hepatitis b virus infection","volume":"45","author":"Wang","year":"2012","journal-title":"Braz J Med Biol Res"},{"key":"2026030321494662900_bib62","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1567-5769(01)00177-1","article-title":"Chronic beryllium disease: a model interaction between innate and acquired immunity","volume":"2","author":"Sawyer","year":"2002","journal-title":"Int Immunopharmacol"},{"key":"2026030321494662900_bib63","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.4049\/jimmunol.180.4.2704","article-title":"Up-regulation of programmed death-1 expression on beryllium-specific CD4+ T cells in chronic beryllium disease","volume":"180","author":"Palmer","year":"2008","journal-title":"J Immunol"},{"key":"2026030321494662900_bib64","first-page":"168","article-title":"Pathogenesis of sarcoidosis","volume":"147","author":"Van Gundy","year":"1987","journal-title":"West J Med"},{"key":"2026030321494662900_bib65","first-page":"11","article-title":"Chronic beryllium disease: a model for pulmonary sarcoidosis?","volume":"76","author":"Richeldi","year":"2005","journal-title":"Acta Biomed"},{"key":"2026030321494662900_bib66","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1183\/13993003.01469-2015","article-title":"Beryllium-induced lung disease exhibits expression profiles similar to sarcoidosis","volume":"47","author":"Li","year":"2016","journal-title":"Eur Respir J"},{"key":"2026030321494662900_bib67","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1165\/rcmb.2018-0177OC","article-title":"DNA methylation changes in lung immune cells are associated with granulomatous lung disease","volume":"60","author":"Yang","year":"2019","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030321494662900_bib68","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1136\/jclinpath-2012-201337","article-title":"Hypersensitivity pneumonitis: a review and update of histologic findings","volume":"66","author":"Grunes","year":"2013","journal-title":"J Clin Pathol"},{"key":"2026030321494662900_bib69","first-page":"170012","article-title":"Differential diagnosis of granulomatous lung disease: Clues and pitfalls: Number 4 in the series \u201cPathology for the Clinician\u201d edited by Peter Dorfmuller and Alberto Cavazza","volume-title":"Eur Respir Rev","author":"Ohshimo","year":"2017"},{"key":"2026030321494662900_bib70","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.coi.2018.09.007","article-title":"Age (autoimmunity) associated B cells (ABCs) and their relatives","volume":"55","author":"Phalke","year":"2018","journal-title":"Curr Opin Immunol"},{"key":"2026030321494662900_bib71","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1146\/annurev.immunol.25.022106.141541","article-title":"Fc receptor-like molecules","volume":"25","author":"Davis","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"2026030321494662900_bib72","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1074-7613(01)00098-X","article-title":"The CD19\/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts","volume":"14","author":"Cherukuri","year":"2001","journal-title":"Immunity"},{"key":"2026030321494662900_bib73","first-page":"29","article-title":"Emerging roles for the FCRL family members in lymphocyte biology and disease","volume":"382","author":"Li","year":"2014","journal-title":"Curr Top Microbiol Immunol"},{"key":"2026030321494662900_bib74","doi-asserted-by":"crossref","first-page":"E1282","DOI":"10.1073\/pnas.1215156110","article-title":"FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030321494662900_bib75","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00000441-200101000-00013","article-title":"Beryllium disease","volume":"321","author":"Saltini","year":"2001","journal-title":"Am J Med Sci"},{"key":"2026030321494662900_bib76","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/MCP.0000000000000403","article-title":"Transcriptome profiles in sarcoidosis and their potential role in disease prediction","volume":"23","author":"Schupp","year":"2017","journal-title":"Curr Opin Pulm Med"},{"key":"2026030321494662900_bib77","first-page":"157","article-title":"Tlr7 gln11leu single nucleotide polymorphism in patients with sarcoidosis","volume-title":"Sarcoidosis Vasc Diffuse Lung Dis","author":"Bordignon","year":"2013"},{"key":"2026030321494662900_bib78","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0167-5699(92)90119-R","article-title":"Slow bacterial infections or autoimmunity?","volume":"13","author":"Rook","year":"1992","journal-title":"Immunol Today"},{"key":"2026030321494662900_bib79","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1055\/s-0036-1580692","article-title":"Hypersensitivity pneumonitis: challenges in diagnosis and management, avoiding surgical lung biopsy","volume":"37","author":"Morell","year":"2016","journal-title":"Semin Respir Crit Care Med"},{"key":"2026030321494662900_bib80","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2014.04.048","article-title":"Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity","volume":"158","author":"Clayton","year":"2014","journal-title":"Cell"},{"key":"2026030321494662900_bib81","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.4049\/jimmunol.1800303","article-title":"Tlr9 and il-1r1 promote mobilization of pulmonary dendritic cells during beryllium sensitization","volume":"201","author":"Wade","year":"2018","journal-title":"J Immunol"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/202\/7\/1013\/67177209\/ajrccm_202_7_1013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/202\/7\/1013\/67177209\/ajrccm_202_7_1013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:50:00Z","timestamp":1772592600000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/202\/7\/1013\/8495419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":81,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,10,1]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201911-2151oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,10,1]]},"assertion":[{"value":"2019-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}