{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:55:45Z","timestamp":1790225745821,"version":"4.1.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Sleep-disordered breathing (SDB) is associated with increased vascular resistance in children and adults. Persistent increased vascular resistance damages vascular endothelial cells\u2014a marker of which is increased platelet activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study compared whole-blood impedance platelet aggregation in children with clinically diagnosed SDB warranting adenotonsillectomy and healthy control subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty children who had SDB warranting intervention clinically diagnosed by experienced pediatric otolaryngologists were recruited from adenotonsillectomy waitlists, and 20 healthy children from the community underwent overnight polysomnography to determine SDB severity (obstructive apnea\u2013hypopnea index). Snoring frequency was collected from parents. In the morning, a fasting blood sample was taken, and whole-blood platelet aggregation was measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Children with SDB exhibited increased platelet aggregation to TRAP (thrombin receptor-activating peptide) (children with SDB\u2009=\u2009114.8 aggregation units [AU] vs. control subjects\u2009=\u200998.0 AU; P\u2009&amp;lt;\u20090.05) and COL antibody (96.7 vs. 82.2 AU; P\u2009&amp;lt;\u20090.05) and an increased trend in ADP antibody (82.3 vs. 69.2 AU; P\u2009&amp;lt;\u20090.07) but not aspirin dialuminate (82.1 vs. 79.5 AU; P\u2009&amp;gt;\u20090.05). No significant association was observed between either the obstructive apnea\u2013hypopnea index and any aggregation parameter, but parental report of snoring was positively associated with TRAP aggregation (Kendall\u2019s \u03c4-c\u2009=\u20090.23; P\u2009&amp;lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The finding of increased platelet aggregation is consistent with endothelial damage. This suggests that the profile of cardiovascular changes noted in adults with SDB may also occur in children with SDB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201911-2229oc","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T14:28:06Z","timestamp":1594045686000},"page":"1560-1566","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":14,"title":["Increased Platelet Aggregation in Children and Adolescents with Sleep-disordered Breathing"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3329-1487","authenticated-orcid":false,"given":"Anna","family":"Kontos","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine and"},{"name":"Robinson Research Institute"},{"name":"Discipline of Paediatrics, School of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Willoughby","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Adelaide, Adelaide, South Australia, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Lushington","sequence":"additional","affiliation":[{"name":"Robinson Research Institute"},{"name":"Centre for Behaviour, Brain and Body, Justice and Society Unit, University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine and"},{"name":"Robinson Research Institute"},{"name":"Discipline of Paediatrics, School of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wabnitz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, 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