{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:08:52Z","timestamp":1792667332726,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":2072,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"DOI":"10.1164\/rccm.202005-1906ed","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T14:43:28Z","timestamp":1590072208000},"page":"16-20","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":82,"title":["Home Nitric Oxide Therapy for COVID-19"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7819-6486","authenticated-orcid":false,"given":"Roger A.","family":"Alvarez","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2702-2093","authenticated-orcid":false,"given":"Lorenzo","family":"Berra","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Gladwin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, and"},{"name":"Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"2026030321461134600_bib1","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1056\/NEJMc2009787","article-title":"Large-vessel stroke as a presenting feature of Covid-19 in the young","volume":"382","author":"Oxley","year":"2020","journal-title":"N Engl J Med"},{"key":"2026030321461134600_bib2","article-title":"Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review","author":"Ye","journal-title":"Eur Radiol"},{"key":"2026030321461134600_bib3","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"key":"2026030321461134600_bib4","article-title":"Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area","author":"Richardson","journal-title":"JAMA"},{"key":"2026030321461134600_bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1164\/rccm.202004-0937LE","article-title":"Outpatient inhaled nitric oxide in a patient with vasoreactive idiopathic pulmonary arterial hypertension and COVID-19 infection [letter]","volume":"202","author":"Zamanian","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321461134600_bib6","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1056\/NEJMra051884","article-title":"Inhaled nitric oxide therapy in adults","volume":"353","author":"Griffiths","year":"2005","journal-title":"N Engl J Med"},{"key":"2026030321461134600_bib7","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1001\/jama.2011.235","article-title":"Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial","volume":"305","author":"Gladwin","year":"2011","journal-title":"JAMA"},{"key":"2026030321461134600_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13613-019-0605-9","article-title":"Effect of nitric oxide on postoperative acute kidney injury in patients who underwent cardiopulmonary bypass: a systematic review and meta-analysis with trial sequential analysis","volume":"9","author":"Hu","year":"2019","journal-title":"Ann Intensive Care"},{"key":"2026030321461134600_bib9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.niox.2019.01.006","article-title":"Inhaled nitric oxide to treat intermediate risk pulmonary embolism: a multicenter randomized controlled trial","volume":"84","author":"Kline","year":"2019","journal-title":"Nitric Oxide"},{"key":"2026030321461134600_bib10","article-title":"A randomized, double-blind, placebo-controlled study to assess the safety and efficacy of pulsed, inhaled nitric oxide at a dose of 30 \u03bcg\/Kg ideal body weight\/hr in subjects at risk of pulmonary hypertension associated with pulmonary fibrosis receiving oxygen therapy","author":"Nathan","journal-title":"Chest"},{"key":"2026030321461134600_bib11","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1086\/425357","article-title":"Inhalation of nitric oxide in the treatment of severe acute respiratory syndrome: a rescue trial in Beijing","volume":"39","author":"Chen","year":"2004","journal-title":"Clin Infect Dis"},{"key":"2026030321461134600_bib12","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1128\/JVI.79.3.1966-1969.2005","article-title":"Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus","volume":"79","author":"Akerstr\u00f6m","year":"2005","journal-title":"J Virol"},{"key":"2026030321461134600_bib13","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1056\/NEJMoa1214103","article-title":"Prone positioning in severe acute respiratory distress syndrome","volume":"368","author":"Gu\u00e9rin","year":"2013","journal-title":"N Engl J Med"},{"key":"2026030321461134600_bib14","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1056\/NEJMoa1005372","article-title":"Neuromuscular blockers in early acute respiratory distress syndrome","volume":"363","author":"Papazian","year":"2010","journal-title":"N Engl J Med"},{"key":"2026030321461134600_bib15","first-page":"A3818","article-title":"An acute dose escalation study to assess the safety and hemodynamic efficacy of pulsed inhaled nitric oxide (iNO) in subjects with pulmonary hypertension associated with pulmonary fibrosis (PF) or sarcoidosis [abstract]","volume":"201","author":"Alvarez","year":"2020","journal-title":"Am J Respir Crit Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/202\/1\/16\/67177587\/ajrccm_202_1_16.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/202\/1\/16\/67177587\/ajrccm_202_1_16.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:46:25Z","timestamp":1772592385000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/202\/1\/16\/8494572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,1]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,7,1]]},"published-print":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202005-1906ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2020,7,1]]},"assertion":[{"value":"2020-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}