{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:57:31Z","timestamp":1772596651930,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":1888,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"DOI":"10.1164\/rccm.202008-3172ed","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T17:07:19Z","timestamp":1598375239000},"page":"5-6","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":10,"title":["Reverse Triggering, the Rhythm Dyssynchrony: Potential Implications for Lung and Diaphragm Protection"],"prefix":"10.1093","volume":"203","author":[{"given":"Irene","family":"Telias","sequence":"first","affiliation":[{"name":"Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, Toronto, Ontario, Canada"},{"name":"Department of Medicine, University Health Network and Sinai Health System, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0797-2374","authenticated-orcid":false,"given":"Jeremy R.","family":"Beitler","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University, New York, New York, and"},{"name":"Center for Acute Respiratory Failure, New York-Presbyterian Hospital, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,1]]},"reference":[{"key":"2026030322034566900_bib1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ccc.2018.03.008","article-title":"Asynchrony consequences and management","volume":"34","author":"Pham","year":"2018","journal-title":"Crit Care Clin"},{"key":"2026030322034566900_bib2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1378\/chest.12-1817","article-title":"Mechanical ventilation-induced reverse-triggered breaths: a frequently unrecognized form of neuromechanical coupling","volume":"143","author":"Akoumianaki","year":"2013","journal-title":"Chest"},{"key":"2026030322034566900_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1164\/rccm.201907-1427OC","article-title":"Reverse trigger phenotypes in acute respiratory distress syndrome","volume":"203","author":"Baedorf Kassis","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030322034566900_bib4","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s00134-016-4423-3","article-title":"Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria","volume":"42","author":"Beitler","year":"2016","journal-title":"Intensive Care Med"},{"key":"2026030322034566900_bib5","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1164\/rccm.201804-0649LE","article-title":"Reverse triggering causes an injurious inflation pattern during mechanical ventilation","volume":"198","author":"Yoshida","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030322034566900_bib6","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1164\/ajrccm.160.3.9712057","article-title":"Entrainment of respiration in humans by periodic lung inflations: effect of state and CO(2)","volume":"160","author":"Simon","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030322034566900_bib7","first-page":"R902","article-title":"Respiratory phase locking during mechanical ventilation in anesthetized human subjects","volume":"250","author":"Graves","year":"1986","journal-title":"Am J Physiol"},{"key":"2026030322034566900_bib8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1139\/y83-092","article-title":"Phase locking of the respiratory rhythm in cats to a mechanical ventilator","volume":"61","author":"Petrillo","year":"1983","journal-title":"Can J Physiol Pharmacol"},{"key":"2026030322034566900_bib9","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1152\/jappl.2000.89.2.760","article-title":"Vagal feedback in the entrainment of respiration to mechanical ventilation in sleeping humans","volume":"89","author":"Simon","year":"2000","journal-title":"J Appl Physiol (1985)"},{"key":"2026030322034566900_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0034-5687(75)90119-X","article-title":"Action of intercostal muscle afferents on the respiratory rhythm of anesthetized cats","volume":"24","author":"Remmers","year":"1975","journal-title":"Respir Physiol"},{"key":"2026030322034566900_bib11","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1164\/rccm.201603-0483LE","article-title":"Patient-ventilator asynchrony due to reverse triggering occurring in brain-dead patients: clinical implications and physiological meaning","volume":"194","author":"Delisle","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030322034566900_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0034-5687(95)00097-6","article-title":"Respiratory muscle coordination in acute spinal dogs","volume":"104","author":"Reinoso","year":"1996","journal-title":"Respir Physiol"},{"key":"2026030322034566900_bib13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1748-1716.1969.tb04459.x","article-title":"Intercostal and cerebellar influences on efferent phrenic activity in the decerebrate cat","volume":"76","author":"Decima","year":"1969","journal-title":"Acta Physiol Scand"},{"key":"2026030322034566900_bib14","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1152\/jappl.2000.88.6.2159","article-title":"Linkage of hiccup with heartbeat","volume":"88","author":"Chen","year":"2000","journal-title":"J Appl Physiol (1985)"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/203\/1\/5\/67162635\/ajrccm_203_1_5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/203\/1\/5\/67162635\/ajrccm_203_1_5.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:05:08Z","timestamp":1772593508000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/203\/1\/5\/8490996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,1]]},"published-print":{"date-parts":[[2021,1,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202008-3172ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1]]},"published":{"date-parts":[[2021,1,1]]},"assertion":[{"value":"2021-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}