{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:28:12Z","timestamp":1784172492848,"version":"3.55.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":1829,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"DOI":"10.1164\/rccm.202009-3706ed","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T18:00:30Z","timestamp":1603476030000},"page":"541-542","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":8,"title":["In Defense of the Nucleus: NUDT1 and Oxidative DNA Damage in Pulmonary Arterial Hypertension"],"prefix":"10.1093","volume":"203","author":[{"given":"Stuti","family":"Agarwal","sequence":"first","affiliation":[{"name":"Divisions of Pulmonary and Critical Care Medicine, and"},{"name":"The Vera Moulton Wall Center for Pulmonary Vascular Medicine, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5532-8247","authenticated-orcid":false,"given":"Vinicio A.","family":"de Jesus Perez","sequence":"additional","affiliation":[{"name":"Divisions of Pulmonary and Critical Care Medicine, and"},{"name":"The Vera Moulton Wall Center for Pulmonary Vascular Medicine, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"2026030322062170300_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cotox.2017.09.001","article-title":"Oxidative stress in the lung - the essential paradox","volume":"7","author":"Rogers","year":"2018","journal-title":"Curr Opin Toxicol"},{"key":"2026030322062170300_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1568-7864(01)00007-6","article-title":"ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage","volume":"1","author":"Barzilai","year":"2002","journal-title":"DNA Repair (Amst)"},{"key":"2026030322062170300_bib3","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.dnarep.2004.03.002","article-title":"DNA damage responses to oxidative stress","volume":"3","author":"Barzilai","year":"2004","journal-title":"DNA Repair (Amst)"},{"key":"2026030322062170300_bib4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1164\/rccm.201606-1226PP","article-title":"Translational advances in the field of pulmonary hypertension: from cancer biology to new pulmonary arterial hypertension therapeutics. Targeting cell growth and proliferation signaling hubs","volume":"195","author":"Pullamsetti","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030322062170300_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1086\/683814","article-title":"Redox biology in pulmonary arterial hypertension (2013 Grover Conference Series)","volume":"5","author":"Fessel","year":"2015","journal-title":"Pulm Circ"},{"key":"2026030322062170300_bib6","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1164\/rccm.201310-1749OC","article-title":"Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension","volume":"189","author":"de Jesus Perez","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030322062170300_bib7","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1165\/rcmb.2013-0349OC","article-title":"Loss of bone morphogenetic protein receptor 2 is associated with abnormal DNA repair in pulmonary arterial hypertension","volume":"50","author":"Li","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030322062170300_bib8","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1164\/rccm.202003-0627OC","article-title":"Oxidized DNA precursors cleanup by NUDT1 contributes to vascular remodeling in pulmonary arterial hypertension","volume":"203","author":"Vitry","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030322062170300_bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00109-017-1619-0","article-title":"FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension","volume":"96","author":"Bourgeois","year":"2018","journal-title":"J Mol Med (Berl)"},{"key":"2026030322062170300_bib10","doi-asserted-by":"crossref","first-page":"e0221728","DOI":"10.1371\/journal.pone.0221728","article-title":"Participation of PLK1 and FOXM1 in the hyperplastic proliferation of pulmonary artery smooth muscle cells in pulmonary arterial hypertension","volume":"14","author":"Wilson","year":"2019","journal-title":"PLoS One"},{"key":"2026030322062170300_bib11","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41419-018-0667-x","article-title":"(S)-crizotinib reduces gastric cancer growth through oxidative DNA damage and triggers pro-survival akt signal","volume":"9","author":"Ji","year":"2018","journal-title":"Cell Death Dis"},{"key":"2026030322062170300_bib12","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1113\/JP275857","article-title":"Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension","volume":"597","author":"Hu","year":"2019","journal-title":"J Physiol"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/203\/5\/541\/67164492\/ajrccm_203_5_541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/203\/5\/541\/67164492\/ajrccm_203_5_541.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:08:19Z","timestamp":1772593699000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/203\/5\/541\/8490975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,3,1]]},"published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202009-3706ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3]]},"published":{"date-parts":[[2021,3,1]]},"assertion":[{"value":"2021-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}