{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T09:15:49Z","timestamp":1772702149116,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":1738,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"DOI":"10.1164\/rccm.202012-4467ed","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T16:20:50Z","timestamp":1610727650000},"page":"1340-1341","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":2,"title":["Very Late Antigen-4: A Novel Receptor for Club Cell Secretory Protein 16 to Control Inflammation"],"prefix":"10.1093","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-4803","authenticated-orcid":false,"given":"Hong Wei","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2880-4436","authenticated-orcid":false,"given":"Niccolette","family":"Schaunaman","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"2026030503475765900_B1","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1164\/rccm.202006-2576OC","article-title":"CC16 binding to \u03b14\u03b21 integrin protects against Mycoplasma pneumoniae infection","volume":"203","author":"Johnson","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030503475765900_B2","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.2147\/COPD.S174545","article-title":"Decreased serum club cell secretory protein in asthma and chronic obstructive pulmonary disease overlap: a pilot study","volume":"13","author":"Oh","year":"2018","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2026030503475765900_B3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0091-6749(95)70153-2","article-title":"Protein content in bronchoalveolar lavage fluid of patients with asthma and control subjects","volume":"95","author":"Van Vyve","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"2026030503475765900_B4","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1378\/chest.08-2465","article-title":"Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury","volume":"135","author":"Kropski","year":"2009","journal-title":"Chest"},{"key":"2026030503475765900_B5","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1136\/thx.2008.102574","article-title":"Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohort","volume":"63","author":"Lomas","year":"2008","journal-title":"Thorax"},{"key":"2026030503475765900_B6","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1164\/ajrccm.160.3.9803113","article-title":"Clara cell protein-positive epithelial cells are reduced in small airways of asthmatics","volume":"160","author":"Shijubo","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030503475765900_B7","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.3389\/fimmu.2019.02276","article-title":"Endogenous uteroglobin as intrinsic anti-inflammatory signal modulates monocyte and macrophage subsets distribution upon sepsis induced lung injury","volume":"10","author":"Janicova","year":"2019","journal-title":"Front Immunol"},{"key":"2026030503475765900_B8","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1183\/09031936.00080913","article-title":"Club cell 10-kDa protein attenuates airway mucus hypersecretion and inflammation","volume":"44","author":"Tokita","year":"2014","journal-title":"Eur Respir J"},{"key":"2026030503475765900_B9","doi-asserted-by":"crossref","first-page":"106327","DOI":"10.1016\/j.intimp.2020.106327","article-title":"Club cell 10-kDa protein (CC10) inhibits cPLA2\/COX2 pathway to alleviate RSV-induced airway inflammation and AHR","volume":"83","author":"Yu","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"2026030503475765900_B10","first-page":"2198","article-title":"Recombinant club cell protein 16 (CC16) ameliorates cigarette smoke-induced lung inflammation in a murine disease model of COPD","volume":"18","author":"Pang","year":"2018","journal-title":"Mol Med Rep"},{"key":"2026030503475765900_B11","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1164\/rccm.200904-0597OC","article-title":"Clara cell 10-kD protein suppresses chitinase 3-like 1 expression associated with eosinophilic chronic rhinosinusitis","volume":"181","author":"Wang","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030503475765900_B12","doi-asserted-by":"crossref","first-page":"e35960","DOI":"10.1371\/journal.pone.0035960","article-title":"Clara cell 10-kDa protein gene transfection inhibits NF-\u03baB activity in airway epithelial cells","volume":"7","author":"Long","year":"2012","journal-title":"PLoS One"},{"key":"2026030503475765900_B13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/135245859600100621","article-title":"The human clara cell protein: biochemical and biological characterisation of a natural immunosuppressor","volume":"1","author":"Dierynck","year":"1996","journal-title":"Mult Scler"},{"key":"2026030503475765900_B14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1164\/rccm.2105034","article-title":"Very late antigen-4 in CD18-independent neutrophil emigration during acute bacterial pneumonia in mice","volume":"166","author":"Tasaka","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030503475765900_B15","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1164\/ajrccm.162.3.9910100","article-title":"Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice","volume":"162","author":"Kanehiro","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030503475765900_B16","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1164\/rccm.200709-1387OC","article-title":"Toll-like receptor 2 down-regulation in established mouse allergic lungs contributes to decreased mycoplasma clearance","volume":"177","author":"Wu","year":"2008","journal-title":"Am J Respir Crit Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/203\/11\/1340\/67235721\/ajrccm_203_11_1340.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/203\/11\/1340\/67235721\/ajrccm_203_11_1340.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T08:48:42Z","timestamp":1772700522000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/203\/11\/1340\/8490939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":16,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,6,1]]},"published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202012-4467ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,6]]},"published":{"date-parts":[[2021,6,1]]},"assertion":[{"value":"2021-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}