{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:56:24Z","timestamp":1793386584623,"version":"4.5.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"French Ministry of Health","award":["PHRC AOM 12116"],"award-info":[{"award-number":["PHRC AOM 12116"]}]},{"DOI":"10.13039\/501100002738","name":"Assistance Publique\u2013H\u00f4pitaux de Paris","doi-asserted-by":"publisher","award":["Appel \u00e0 projet interne 2017"],"award-info":[{"award-number":["Appel \u00e0 projet interne 2017"]}],"id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French Ministry of Health","award":["PHRC AOM 12116"],"award-info":[{"award-number":["PHRC AOM 12116"]}]},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris","award":["Appel \u00e0 projet interne 2017"],"award-info":[{"award-number":["Appel \u00e0 projet interne 2017"]}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Dyspnea is a traumatic experience. Only limited information is available on dyspnea in intubated critically ill patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our objectives were 1) to quantify the prevalence and severity of dyspnea; and 2) to evaluate the impact of dyspnea on ICU length of stay and post-traumatic stress disorder (PTSD) 90 days after ICU discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective cohort study in 10 ICUs in France. In patients intubated for more than 24 hours, dyspnea was quantified with a visual analog scale (from 0 to 10) as soon as they were able to communicate, the following day, and before spontaneous breathing trials. PTSD was defined by an Impact of Event Scale-Revised score of at least 22.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Among the 612 patients assessed, 34% reported dyspnea, with a median dyspnea rating of 5 (interquartile range, 4\u20137). ICU length of stay was not significantly different between patients with versus without dyspnea (6 [3\u201312] and 6 [3\u201313] days, respectively; P\u2009=\u20090.781). Mortality was not different between groups. Of the 153 patients interviewed on Day 90, a higher proportion of individuals with probable PTSD was observed among patients who were dyspneic on enrollment (29% vs. 13%; P\u2009=\u20090.017). The density of dyspnea (number of dyspneic episodes divided by time from enrollment to extubation) was independently associated with PTSD (odds ratio, 1.07; 95% confidence interval, 1.01\u20131.13; P\u2009=\u20090.031).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dyspnea was frequent and intense in intubated critically ill patients. ICU length of stay was not significantly different among patients reporting dyspnea, but PTSD was more frequent at Day 90.<\/jats:p>\n                    <jats:p>Clinical trial registered with www.clinicaltrials.gov(NCT 02336464).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202108-1857oc","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T15:51:11Z","timestamp":1642780271000},"page":"917-926","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":91,"title":["Prevalence, Intensity, and Clinical Impact of Dyspnea in Critically Ill Patients Receiving Invasive Ventilation"],"prefix":"10.1093","volume":"205","author":[{"given":"Alexandre","family":"Demoule","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, Paris, France"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), Groupe Hospitalier Universitaire APHP-Sorbonne Universit\u00e9, site Piti\u00e9-Salp\u00eatri\u00e8re, Service de M\u00e9decine Intensive et R\u00e9animation, Paris, France"},{"name":"Sorbonne Universit\u00e9, GRC 30, Reanimation et Soins Intensifs du Patient en Insuffisance Respiratoire Aig\u00fce, AP-HP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hajage","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Universitaire APHP-Sorbonne Universit\u00e9, site Piti\u00e9-Salp\u00eatri\u00e8re, D\u00e9partement Biostatistique Sant\u00e9 Publique et Information M\u00e9dicale, Centre de Pharmaco\u00e9pid\u00e9miologie (Cephepi), Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, CIC-1421, Paris, 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