{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:55:33Z","timestamp":1792799733856,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"European Respiratory Society through the European Multicentre Bronchiectasis Audit and Research Collaboration 2","award":["EMBARC2 Consortium"],"award-info":[{"award-number":["EMBARC2 Consortium"]}],"id":[{"id":"https:\/\/ror.org\/00c8n3h65","id-type":"ROR","asserted-by":"crossref"}]},{"name":"European Respiratory Society through the European Multicentre Bronchiectasis Audit and Research Collaboration 2","award":["EMBARC2 Consortium"],"award-info":[{"award-number":["EMBARC2 Consortium"]}],"id":[{"id":"https:\/\/ror.org\/00c8n3h65","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Bronchiectasis is classically considered a neutrophilic disorder, but eosinophilic subtypes have recently been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To use multiple datasets available through the European Multicentre Bronchiectasis Audit and Research Collaboration to characterize eosinophilic bronchiectasis as a clinical entity focusing on the impact of eosinophils on bronchiectasis exacerbations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were included from five countries to examine the relationships between blood eosinophil counts and clinical phenotypes after excluding coexisting asthma. 16S rRNA sequencing was used to examine relationships between eosinophil counts and the sputum microbiome. A post hoc analysis of the PROMIS (Inhaled Promixin in the Treatment of Non\u2013Cystic Fibrosis Bronchiectasis) phase 2 trial was used to examine the impact of blood eosinophil counts on exacerbations in patients with Pseudomonas aeruginosa infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>A relationship between sputum and blood eosinophil counts was demonstrated in two cohorts. In analysis of 1,007 patients from five countries, 22.6% of patients had blood eosinophil counts of \u2a7e300 cells\/\u03bcl. Counts of &amp;lt;100 cells\/\u03bcl were associated with higher bronchiectasis severity and increased mortality. There was no clear relationship with exacerbations. Blood eosinophil counts of \u2a7e300 cells\/\u03bcl were associated with both Streptococcus- and Pseudomonas-dominated microbiome profiles. To investigate the relationship of eosinophil counts with exacerbations after controlling for the confounding effects of infection, 144 patients were studied in a clinical trial after treatment with antipseudomonal antibiotics. Compared with patients with blood eosinophil counts of &amp;lt;100 cells\/\u03bcl (reference), elevated eosinophil counts of 100\u2013299 cells\/\u03bcl (hazard ratio, 2.38; 95% confidence interval, 1.33\u20134.25; P\u2009=\u20090.003) and \u2a7e300 cells\/\u03bcl (hazard ratio, 3.99; 95% confidence interval, 2.20\u20137.85; P\u2009&amp;lt;\u20090.0001) were associated with shorter time to exacerbation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Eosinophilic bronchiectasis affects approximately 20% of patients. After accounting for infection status, raised blood eosinophil counts are associated with shortened time to exacerbation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202108-1889oc","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T14:24:20Z","timestamp":1642688660000},"page":"894-902","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":224,"title":["Characterization of Eosinophilic Bronchiectasis: A European Multicohort Study"],"prefix":"10.1093","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-6060","authenticated-orcid":false,"given":"Amelia","family":"Shoemark","sequence":"first","affiliation":[{"name":"Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom"},{"name":"Royal Brompton Hospital and Imperial College London, London, United 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