{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:27:08Z","timestamp":1790803628890,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100006021","name":"Direction G\u00e9n\u00e9rale de l\u2019Armement","doi-asserted-by":"publisher","award":["BIOMEDEF"],"award-info":[{"award-number":["BIOMEDEF"]}],"id":[{"id":"10.13039\/501100006021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006021","name":"Direction G\u00e9n\u00e9rale de l\u2019Armement","doi-asserted-by":"crossref","award":["BIOMEDEF"],"award-info":[{"award-number":["BIOMEDEF"]}],"id":[{"id":"10.13039\/501100006021","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Norepinephrine (NE) is commonly used in combination with fluid during resuscitation of hemorrhagic shock, but its impact on kidney microcirculation, oxygenation, and function is still unknown in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>During hemorrhagic shock resuscitation, does a combination of fluid and NE affect kidney oxygenation tension, kidney microcirculatory perfusion, and 48-hour kidney function, as compared with fluid alone?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Hemorrhagic shock was induced in 24 pigs, and 8 pigs were included as a sham group. Resuscitation of hemorrhagic shock was performed, using a closed-loop device, either by fluid alone (0.9% NaCl; fluid group) or associated with the administration of NE at two doses (moderate dose: mean rate of 0.64 \u03bcg\u2009\u22c5\u2009kg\u22121\u2009\u22c5\u2009min\u22121; high dose: mean rate of 1.57 \u03bcg\u2009\u22c5\u2009kg\u22121\u2009\u22c5\u2009min\u22121) to obtain a target systolic arterial pressure of 80 to 90 mm Hg. Resuscitation was followed by transfusion of the withdrawn blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>The amount of fluid required to reach the target systolic arterial pressure was lower in the NE groups than in the fluid group, with subsequently less hemodilution. NE restored kidney microcirculation, oxygenation, and function in a manner comparable to that achieved with fluid resuscitation alone. There were no histologic differences between animals resuscitated with fluid and those resuscitated with NE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In pigs with hemorrhagic shock, resuscitation with a combination of NE and fluid restored kidney microcirculation and oxygenation, as well as renal function, in a manner comparable to fluid resuscitation alone and without differences between the two NE doses. NE administration led to a fluid volume\u2013sparing effect with subsequently less hemodilution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202109-2120oc","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T11:30:33Z","timestamp":1649417433000},"page":"34-43","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":12,"title":["Renal Microcirculation and Function in a Pig Model of Hemorrhagic Shock Resuscitation with Norepinephrine"],"prefix":"10.1093","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2085-8031","authenticated-orcid":false,"given":"Nicolas","family":"Libert","sequence":"first","affiliation":[{"name":"Laboratoire d\u2019\u00c9tude de la Microcirculation, UMR 942, Universit\u00e9 Paris 7-11-13, Paris, France"},{"name":"Service d\u2019Anesth\u00e9sie-R\u00e9animation, H\u00f4pital d\u2019Instruction des Arm\u00e9es Percy, Clamart, France"},{"name":"Institut de Recherche Biom\u00e9dical des Arm\u00e9es and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Laemmel","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019\u00c9tude de la Microcirculation, UMR 942, Universit\u00e9 Paris 7-11-13, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatole","family":"Harrois","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019\u00c9tude de la Microcirculation, UMR 942, Universit\u00e9 Paris 7-11-13, Paris, France"},{"name":"Service d\u2019Anesth\u00e9sie-R\u00e9animation Chirurgicale, UMR 942, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris-Saclay, Assistance Publique - H\u00f4pitaux de Paris, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Laitselart","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019\u00c9tude de la Microcirculation, UMR 942, Universit\u00e9 Paris 7-11-13, Paris, France"},{"name":"Service d\u2019Anesth\u00e9sie-R\u00e9animation, H\u00f4pital d\u2019Instruction des Arm\u00e9es Percy, Clamart, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bergis","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019\u00c9tude de la Microcirculation, UMR 942, Universit\u00e9 Paris 7-11-13, Paris, France"},{"name":"Service d\u2019Anesth\u00e9sie-R\u00e9animation Chirurgicale, UMR 942, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris-Saclay, Assistance Publique - H\u00f4pitaux de Paris, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Isnard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM U1151, CNRS UMR 8253, Institut Necker Enfants Malades, D\u00e9partement \u00ab Croissance et Signalisation \u00bb, Paris, France"},{"name":"D\u00e9partement d\u2019anatomie pathologique, Centre Hospitalier Universitaire Necker-Enfants Malades, Assistance Publique - H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Terzi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM U1151, CNRS UMR 8253, Institut Necker Enfants Malades, D\u00e9partement \u00ab Croissance et Signalisation \u00bb, Paris, France"},{"name":"D\u00e9partement d\u2019anatomie pathologique, Centre Hospitalier Universitaire Necker-Enfants Malades, Assistance Publique - H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Decante","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche et d\u2019Innovation, H\u00f4pital Marie Lannelongue, Le Plessis-Robinson, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Mercier","sequence":"additional","affiliation":[{"name":"\u00c9cole de M\u00e9decine, Universit\u00e9 Paris-Sud et Paris-Saclay, Le Kremlin-Bic\u00eatre, France"},{"name":"D\u00e9partement de Chirurgie Thoracique et Vasculaire et Transplantation Coeur-Poumon, D\u00e9partement Hospitalo-Universitaire Thorax Innovation, INSERM UMR-S 999, LabEX Laboratoire d\u2019Excellence en Recherche sur le M\u00e9dicament et l\u2019Innovation Th\u00e9rapeutique, H\u00f4pital Marie Lannelongue, Le Plessis-Roninson, France; 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