{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:45:14Z","timestamp":1775285114673,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":1554,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,15]]},"DOI":"10.1164\/rccm.202109-2153ed","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T18:05:35Z","timestamp":1634148335000},"page":"1365-1367","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":6,"title":["Double Trouble: Airflow and Pulmonary Vascular Obstruction"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5739-8369","authenticated-orcid":false,"given":"Michael H.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, California"},{"name":"Department of Medicine, Zuckerberg San Francisco General Hospital, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian B.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, California"},{"name":"Department of Medicine, Zuckerberg San Francisco General Hospital, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd M.","family":"Bull","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Disease Center, University of Colorado, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"2026030322003348700_bib1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1152\/jappl.1991.70.1.384","article-title":"Neonatal calves develop airflow limitation due to chronic hypobaric hypoxia","volume":"70","author":"Inscore","year":"1991","journal-title":"J Appl Physiol (1985)"},{"key":"2026030322003348700_bib2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1378\/chest.83.5.732","article-title":"Peripheral airways obstruction in idiopathic pulmonary artery hypertension (primary)","volume":"83","author":"Fernandez-Bonetti","year":"1983","journal-title":"Chest"},{"key":"2026030322003348700_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/000992289903800104","article-title":"Airway responsiveness to inhaled albuterol in patients with pulmonary hypertension","volume":"38","author":"O\u2019Hagan","year":"1999","journal-title":"Clin Pediatr (Phila)"},{"key":"2026030322003348700_bib4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/thorax.57.6.473","article-title":"Peripheral airway obstruction in primary pulmonary hypertension","volume":"57","author":"Meyer","year":"2002","journal-title":"Thorax"},{"key":"2026030322003348700_bib5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.rmed.2011.10.018","article-title":"Dynamic hyperinflation during exercise in patients with precapillary pulmonary hypertension","volume":"106","author":"Richter","year":"2012","journal-title":"Respir Med"},{"key":"2026030322003348700_bib6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1183\/09031936.00223611","article-title":"Dynamic respiratory mechanics and exertional dyspnoea in pulmonary arterial hypertension","volume":"41","author":"Laveneziana","year":"2013","journal-title":"Eur Respir J"},{"key":"2026030322003348700_bib7","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1183\/09031936.00153214","article-title":"Inspiratory muscle function, dynamic hyperinflation and exertional dyspnoea in pulmonary arterial hypertension","volume":"45","author":"Laveneziana","year":"2015","journal-title":"Eur Respir J"},{"key":"2026030322003348700_bib8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1183\/09031936.04.00095804","article-title":"Respiratory muscle dysfunction in idiopathic pulmonary arterial hypertension","volume":"25","author":"Meyer","year":"2005","journal-title":"Eur Respir J"},{"key":"2026030322003348700_bib9","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1164\/rccm.201003-0354OC","article-title":"Diaphragm muscle fiber weakness in pulmonary hypertension","volume":"183","author":"de Man","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030322003348700_bib10","doi-asserted-by":"crossref","first-page":"1802108","DOI":"10.1183\/13993003.02108-2018","article-title":"Intensity and quality of exertional dyspnoea in patients with stable pulmonary hypertension","volume":"55","author":"Boucly","year":"2020","journal-title":"Eur Respir J"},{"key":"2026030322003348700_bib11","doi-asserted-by":"crossref","first-page":"e232468","DOI":"10.1136\/bcr-2019-232468","article-title":"Central airway compression by massively dilated pulmonary artery in a patient with pulmonary arterial hypertension: a rare entity","volume":"12","author":"Saha","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2026030322003348700_bib12","first-page":"e5354","article-title":"Bronchial obstruction caused by a dilated pulmonary artery","volume":"11","author":"Sandhu","year":"2019","journal-title":"Cureus"},{"key":"2026030322003348700_bib13","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.202105-1169LE","article-title":"Evolution of obstructive lung function in advanced pulmonary arterial hypertension [letter]","volume":"204","author":"Rahaghi","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030322003348700_bib14","doi-asserted-by":"crossref","first-page":"e028150","DOI":"10.1136\/bmjopen-2018-028150","article-title":"Rate of normal lung function decline in ageing adults: a systematic review of prospective cohort studies","volume":"9","author":"Thomas","year":"2019","journal-title":"BMJ Open"},{"key":"2026030322003348700_bib15","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/resp.13768","article-title":"Diagnostic delay in pulmonary arterial hypertension: Insights from the Australian and New Zealand pulmonary hypertension registry","volume":"25","author":"Khou","year":"2020","journal-title":"Respirology"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/204\/12\/1365\/67013102\/ajrccm_204_12_1365.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/204\/12\/1365\/67013102\/ajrccm_204_12_1365.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:01:12Z","timestamp":1772593272000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/204\/12\/1365\/8492438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":15,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12,15]]},"published-print":{"date-parts":[[2021,12,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202109-2153ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12]]},"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"2021-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}