{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:22:01Z","timestamp":1790767321155,"version":"4.1.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["Projektnummer 268555672"],"award-info":[{"award-number":["Projektnummer 268555672"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["SFB 1213"],"award-info":[{"award-number":["SFB 1213"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["Projects B08, CP02"],"award-info":[{"award-number":["Projects B08, CP02"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["Projektnummer 268555672"],"award-info":[{"award-number":["Projektnummer 268555672"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["SFB 1213"],"award-info":[{"award-number":["SFB 1213"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["Projects B08, CP02"],"award-info":[{"award-number":["Projects B08, CP02"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"DOI":"10.1164\/rccm.202201-0095le","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T11:57:13Z","timestamp":1650023833000},"page":"111-114","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":18,"title":["Inhaled Iloprost Improves Right Ventricular Load\u2013Independent Contractility in Pulmonary Hypertension"],"prefix":"10.1093","volume":"206","author":[{"given":"Khodr","family":"Tello","sequence":"first","affiliation":[{"name":"Universities of Giessen and Marburg Lung Center, Giessen, Germany"},{"name":"Justus-Liebig University, Giessen, Germany"},{"name":"Excellence Cluster Cardio-Pulmonary Institute, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-0214","authenticated-orcid":false,"given":"Nils","family":"Kremer","sequence":"additional","affiliation":[{"name":"Universities of Giessen and Marburg Lung Center, Giessen, Germany"},{"name":"Justus-Liebig University, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel J.","family":"Richter","sequence":"additional","affiliation":[{"name":"Universities of Giessen and Marburg Lung Center, Giessen, Germany"},{"name":"Justus-Liebig University, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Gall","sequence":"additional","affiliation":[{"name":"Universities of Giessen and Marburg Lung Center, Giessen, Germany"},{"name":"Justus-Liebig University, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Muenks","sequence":"additional","affiliation":[{"name":"Excellence Cluster Cardio-Pulmonary Institute, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardeschir","family":"Ghofrani","sequence":"additional","affiliation":[{"name":"Universities of Giessen and Marburg Lung Center, Giessen, Germany"},{"name":"Justus-Liebig University, Giessen, Germany"},{"name":"Excellence Cluster Cardio-Pulmonary Institute, Giessen, Germany"},{"name":"Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Schermuly","sequence":"additional","affiliation":[{"name":"Excellence Cluster Cardio-Pulmonary Institute, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Naeije","sequence":"additional","affiliation":[{"name":"Free University of Brussels Campus de la Plaine, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baktybek","family":"Kojonazarov","sequence":"additional","affiliation":[{"name":"Excellence Cluster Cardio-Pulmonary Institute, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Seeger","sequence":"additional","affiliation":[{"name":"Universities of Giessen and Marburg Lung Center, Giessen, Germany"},{"name":"Justus-Liebig University, Giessen, Germany"},{"name":"Excellence Cluster Cardio-Pulmonary Institute, Giessen, Germany"},{"name":"Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"},{"name":"Institute for Lung Health (ILH), Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"2026022021143202100_bib1","doi-asserted-by":"crossref","first-page":"1801889","DOI":"10.1183\/13993003.01889-2018","article-title":"Risk stratification and medical therapy of pulmonary arterial hypertension","volume":"53","author":"Gali\u00e8","year":"2019","journal-title":"Eur Respir J"},{"key":"2026022021143202100_bib2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1183\/09031936.00097107","article-title":"Prostacyclin therapies for the treatment of pulmonary arterial hypertension","volume":"31","author":"Gomberg-Maitland","year":"2008","journal-title":"Eur Respir J"},{"key":"2026022021143202100_bib3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1748-1716.1981.tb06847.x","article-title":"Cyclic AMP-dependent and -independent effects of prostaglandins on the contraction-relaxation cycle of spontaneously beating isolated rat atria","volume":"112","author":"Mets\u00e4-Ketel\u00e4","year":"1981","journal-title":"Acta Physiol Scand"},{"key":"2026022021143202100_bib4","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jacc.2018.12.076","article-title":"Anatomy, function, and dysfunction of the right ventricle: JACC state-of-the-art review","volume":"73","author":"Sanz","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2026022021143202100_bib5","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1164\/rccm.200611-1615OC","article-title":"How prostacyclin improves cardiac output in right heart failure in conjunction with pulmonary hypertension","volume":"175","author":"Kerbaul","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026022021143202100_bib6","doi-asserted-by":"crossref","first-page":"1700764","DOI":"10.1183\/13993003.00764-2017","article-title":"How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension","volume":"50","author":"Vanderpool","year":"2017","journal-title":"Eur Respir J"},{"key":"2026022021143202100_bib7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1164\/rccm.201906-1195LE","article-title":"Evaluation and prognostic relevance of right ventricular-arterial coupling in pulmonary hypertension","volume":"201","author":"Richter","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2026022021143202100_bib8","doi-asserted-by":"crossref","first-page":"e005512","DOI":"10.1161\/CIRCHEARTFAILURE.118.005512","article-title":"Reserve of right ventricular-arterial coupling in the setting of chronic overload","volume":"12","author":"Tello","year":"2019","journal-title":"Circ Heart Fail"},{"key":"2026022021143202100_bib9","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1164\/rccm.201802-0283LE","article-title":"More on single-beat estimation of right ventriculoarterial coupling in pulmonary arterial hypertension","volume":"198","author":"Tello","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2026022021143202100_bib10","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1113\/EP085963","article-title":"Maintained right ventricular pressure overload induces ventricular-arterial decoupling in mice","volume":"102","author":"Boehm","year":"2017","journal-title":"Exp Physiol"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/206\/1\/111\/67000746\/ajrccm_206_1_111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/206\/1\/111\/67000746\/ajrccm_206_1_111.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:14:37Z","timestamp":1771640077000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/206\/1\/111\/8491739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,7,1]]},"published-print":{"date-parts":[[2022,7,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202201-0095le","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7]]},"published":{"date-parts":[[2022,7,1]]},"assertion":[{"value":"2022-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}