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Those negative for TB disease were followed for 1 year for the occurrence of new TB diagnoses. We assessed the protective efficacy of IPT in children with and without abnormal chest radiographs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Compared with asymptomatic children with normal chest films, asymptomatic children with abnormal radiographs were 25.1-fold more likely to have coprevalent TB (95% confidence interval [CI], 1.02\u2013613.76) and 26.7-fold more likely to be diagnosed with incident TB disease during follow-up (95% CI, 10.44\u201368.30). Among the 29 symptom-negative and CXR-abnormal child contacts, 20% (3\/15) of the isoniazid recipients developed incident TB, compared with 57% (8\/14) of those who did not receive IPT (82% IPT efficacy).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results strongly support the use of chest radiography as a routine screening tool for the evaluation of child TB contacts, which is readily available. Radiographic abnormalities not usually considered suggestive of TB may indicate incipient or subclinical disease, although TB preventive treatment is adequate in most cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202202-0259oc","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T10:54:45Z","timestamp":1653389685000},"page":"892-900","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":12,"title":["The Contribution of Chest Radiography to the Clinical Management of Children Exposed to Tuberculosis"],"prefix":"10.1093","volume":"206","author":[{"given":"Chuan-Chin","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Global Health Equity, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Global Health and Social Medicine, Harvard Medical School, Boston, 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