{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:39:00Z","timestamp":1793151540771,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"French National Research Program for Environmental and Occupational Health of Anses","award":["2018\/1\/055"],"award-info":[{"award-number":["2018\/1\/055"]}]},{"name":"French National Research Program for Environmental and Occupational Health of Anses","award":["2018\/1\/055"],"award-info":[{"award-number":["2018\/1\/055"]}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>RationaleAlthough previous studies in environmental epidemiology focused on single or a few exposures, a holistic approach combining multiple preventable risk factors is needed to tackle the etiology of multifactorial diseases such as asthma.<\/jats:p>\n                  <jats:p>ObjectivesTo investigate the association between combined socioeconomic, external environment, early-life environment, and lifestyle-anthropometric factors and asthma phenotypes.<\/jats:p>\n                  <jats:p>MethodsA total of 20,833 adults from the French NutriNet-Sant\u00e9 cohort were included (mean age, 56.2 yr; SD, 13.2; 72% women). The validated asthma symptom score (continuous) and asthma control (never asthma, controlled asthma, and uncontrolled asthma) were considered. The exposome (n\u2009=\u200987 factors) covered four domains: socioeconomic, external environment, early-life environment, and lifestyle-anthropometric. Cluster-based analyses were performed within each exposome domain, and the identified profiles were studied in association to asthma outcomes in negative binomial (asthma symptom score) or multinomial logistic (asthma control) regression models.<\/jats:p>\n                  <jats:p>Measurements and Main ResultsIn total, 5,546 (27%) individuals had an asthma symptom score \u2a7e1, and 1,206 (6%) and 194 (1%) had controlled and uncontrolled asthma, respectively. Three early-life exposure profiles (\u201chigh passive smoking\u2013own dogs,\u201d \u201cpoor birth parameters\u2013daycare attendance\u2013city center,\u201d or \u201c\u2a7e2 siblings\u2013breastfed\u201d compared with \u201cfarm\u2013pet owner\u2013molds\u2013low passive smoking\u201d) and one lifestyle-anthropometric profile (\u201cunhealthy diet\u2013high smoking\u2013overweight\u201d compared with \u201chealthy diet\u2013nonsmoker\u2013thin\u201d) were associated with more asthma symptoms and uncontrolled asthma.<\/jats:p>\n                  <jats:p>ConclusionsThis large-scale exposome-based study revealed early-life and lifestyle exposure profiles that were at risk for asthma in adults. Our findings support the importance of multiinterventional programs for the primary and secondary prevention of asthma, including control of specific early-life risk factors and promotion of a healthy lifestyle in adulthood.<\/jats:p>","DOI":"10.1164\/rccm.202205-0865oc","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T15:16:45Z","timestamp":1657552605000},"page":"1208-1219","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":32,"title":["Exposome Profiles and Asthma among French Adults"],"prefix":"10.1093","volume":"206","author":[{"given":"Alicia","family":"Guillien","sequence":"first","affiliation":[{"name":"University of Grenoble Alpes, French National Institute of Health and Medical Research, French National Center for Scientific Research, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"B\u00e9dard","sequence":"additional","affiliation":[{"name":"French National Institute of Health and Medical Research, Joint Research Unit 1018, Center for Research in Epidemiology and Population Health Integrative Respiratory Epidemiology Team, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orianne","family":"Dumas","sequence":"additional","affiliation":[{"name":"French National Institute of Health and Medical Research, Joint Research Unit 1018, Center for Research in Epidemiology and Population Health Integrative Respiratory Epidemiology Team, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Allegre","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, French National Institute of Health and Medical Research U1153, National Research Institute for Agriculture, Food and Environment U1125, French National Conservatory of Arts and Crafts, Nutritional Epidemiology Research Team, Epidemiology and Statistics Research Center - University of Paris, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Arnault","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, French National Institute of Health and Medical Research U1153, National Research Institute for Agriculture, Food and Environment U1125, French National Conservatory of Arts and Crafts, Nutritional Epidemiology Research Team, Epidemiology and Statistics Research Center - University of Paris, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Bochaton","sequence":"additional","affiliation":[{"name":"Joint Research Unit French National Center for Scientific Research 7533 Social Dynamics and Recomposition of Spaces Laboratory, Department of Geography, University of Paris Nanterre, Nanterre, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Druesne-Pecollo","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, French National Institute of Health and Medical Research U1153, National Research Institute for Agriculture, Food and Environment U1125, French National Conservatory of Arts and Crafts, Nutritional Epidemiology Research Team, Epidemiology and Statistics Research Center - University of Paris, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Dumay","sequence":"additional","affiliation":[{"name":"Department of Geography, Joint Research Unit French National Center for Scientific Research 7533 Social Dynamics and Recomposition of Spaces Laboratory, University of Paris 8 Vincennes-Saint-Denis, Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9opold K.","family":"Fezeu","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, French National Institute of Health and Medical Research U1153, National Research Institute for Agriculture, Food and Environment U1125, French National Conservatory of Arts and Crafts, Nutritional Epidemiology Research Team, Epidemiology and Statistics Research Center - University of Paris, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Hercberg","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, French National Institute of Health and Medical Research U1153, National Research Institute for Agriculture, Food and Environment U1125, French National Conservatory of Arts and Crafts, Nutritional Epidemiology Research Team, Epidemiology and Statistics Research Center - University of Paris, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Le Moual","sequence":"additional","affiliation":[{"name":"French National Institute of Health and Medical Research, Joint Research Unit 1018, Center for Research in Epidemiology and Population Health Integrative Respiratory Epidemiology Team, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Pilkington","sequence":"additional","affiliation":[{"name":"Department of Geography, Joint Research Unit French National Center for Scientific Research 7533 Social Dynamics and Recomposition of Spaces Laboratory, University of Paris 8 Vincennes-Saint-Denis, Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Rican","sequence":"additional","affiliation":[{"name":"Joint Research Unit French National Center for Scientific Research 7533 Social Dynamics and Recomposition of Spaces Laboratory, Department of Geography, University of Paris Nanterre, Nanterre, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Sit","sequence":"additional","affiliation":[{"name":"French National Institute of Health and Medical Research, Joint Research Unit 1018, Center for Research in Epidemiology and Population Health Integrative Respiratory Epidemiology Team, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien Szabo","family":"de Edelenyi","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, French National Institute of Health and Medical Research U1153, National Research Institute for Agriculture, Food and Environment U1125, French National Conservatory of Arts and Crafts, Nutritional Epidemiology Research Team, Epidemiology and Statistics Research Center - University of Paris, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Touvier","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, French National Institute of Health and Medical Research U1153, National Research Institute for Agriculture, Food and Environment U1125, French National Conservatory of Arts and Crafts, Nutritional Epidemiology Research Team, Epidemiology and Statistics Research Center - University of Paris, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Galan","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, French National Institute of Health and Medical Research U1153, National Research Institute for Agriculture, Food and Environment U1125, French National Conservatory of Arts and Crafts, Nutritional Epidemiology Research Team, Epidemiology and Statistics Research Center - University of Paris, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Feuillet","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, French National Institute of Health and Medical Research U1153, National Research Institute for Agriculture, Food and Environment U1125, French National Conservatory of Arts and Crafts, Nutritional Epidemiology Research Team, Epidemiology and Statistics Research Center - University of Paris, Bobigny, France"},{"name":"Department of Geography, Joint Research Unit French National Center for Scientific Research 7533 Social Dynamics and Recomposition of Spaces Laboratory, University of Paris 8 Vincennes-Saint-Denis, Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00eblle","family":"Varraso","sequence":"additional","affiliation":[{"name":"French National Institute of Health and Medical Research, Joint Research Unit 1018, Center for Research in Epidemiology and Population Health Integrative Respiratory Epidemiology Team, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Siroux","sequence":"additional","affiliation":[{"name":"University of Grenoble Alpes, French National Institute of Health and Medical Research, French National Center for Scientific Research, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"2026022021220068200_bib1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1164\/rccm.201901-0016OC","article-title":"The projected economic and health burden of uncontrolled asthma in the United States","volume":"200","author":"Yaghoubi","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2026022021220068200_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rmed.2015.11.002","article-title":"Achieving asthma control with ICS\/LABA: a review of strategies for asthma management and prevention","volume":"111","author":"Aalbers","year":"2016","journal-title":"Respir Med"},{"key":"2026022021220068200_bib3","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0140-6736(15)00156-7","article-title":"Risk factors for asthma: is prevention possible?","volume":"386","author":"Beasley","year":"2015","journal-title":"Lancet"},{"key":"2026022021220068200_bib4","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1164\/rccm.201809-1729LE","article-title":"Environmental tobacco smoke affects lung function of preschoolers with asthma even after a decade","volume":"199","author":"Lajunen","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2026022021220068200_bib5","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1164\/rccm.201909-1744OC","article-title":"Air pollution as a risk factor for incident chronic obstructive pulmonary disease and asthma: a 15-year population-based cohort study","volume":"203","author":"Shin","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026022021220068200_bib6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11882-014-0419-7","article-title":"Environmental remediation in the treatment of allergy and asthma: latest updates","volume":"14","author":"Wright","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"2026022021220068200_bib7","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMra1301758","article-title":"Occupational asthma","volume":"370","author":"Tarlo","year":"2014","journal-title":"N Engl J Med"},{"key":"2026022021220068200_bib8","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1164\/rccm.201601-0164OC","article-title":"Asthma trajectories in a population-based birth cohort","volume":"195","author":"Sbihi","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2026022021220068200_bib9","doi-asserted-by":"crossref","first-page":"1702572","DOI":"10.1183\/13993003.02572-2017","article-title":"Associations between dietary scores with asthma symptoms and asthma control in adults","volume":"52","author":"Andrianasolo","year":"2018","journal-title":"Eur Respir J"},{"key":"2026022021220068200_bib10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jped.2016.05.006","article-title":"Lower prevalence and greater severity of asthma in hot and dry climate","volume":"93","author":"Correia Junior","year":"2017","journal-title":"J Pediatr (Rio J)"},{"key":"2026022021220068200_bib11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1164\/rccm.200612-1793OC","article-title":"The use of household cleaning sprays and adult asthma: an international longitudinal study","volume":"176","author":"Zock","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026022021220068200_bib12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10654-018-0398-4","article-title":"From John Snow to omics: the long journey of environmental epidemiology","volume":"33","author":"Vineis","year":"2018","journal-title":"Eur J Epidemiol"},{"key":"2026022021220068200_bib13","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1158\/1055-9965.EPI-05-0456","article-title":"Complementing the genome with an \u201cexposome\u201d: the outstanding challenge of environmental exposure measurement in molecular epidemiology","volume":"14","author":"Wild","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2026022021220068200_bib14","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.anai.2017.01.002","article-title":"The Kingston Allergy Birth Cohort: exploring parentally reported respiratory outcomes through the lens of the exposome","volume":"118","author":"North","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2026022021220068200_bib15","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/S2542-5196(19)30010-5","article-title":"Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort","volume":"3","author":"Agier","year":"2019","journal-title":"Lancet Planet Health"},{"key":"2026022021220068200_bib16","doi-asserted-by":"crossref","first-page":"106038","DOI":"10.1016\/j.envint.2020.106038","article-title":"Multiple environmental exposures in early-life and allergy-related outcomes in childhood","volume":"144","author":"Granum","year":"2020","journal-title":"Environ Int"},{"key":"2026022021220068200_bib17","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1164\/rccm.200711-1754OC","article-title":"Cluster analysis and clinical asthma phenotypes","volume":"178","author":"Haldar","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"2026022021220068200_bib18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/rccm.200906-0896OC","article-title":"Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program","volume":"181","author":"Moore","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"2026022021220068200_bib19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1183\/09031936.00120810","article-title":"Identifying adult asthma phenotypes using a clustering approach","volume":"38","author":"Siroux","year":"2011","journal-title":"Eur Respir J"},{"key":"2026022021220068200_bib20","doi-asserted-by":"crossref","first-page":"138418","DOI":"10.1016\/j.scitotenv.2020.138418","article-title":"Prenatal phthalate, paraben, and phenol exposure and childhood allergic and respiratory outcomes: evaluating exposure to chemical mixtures","volume":"725","author":"Berger","year":"2020","journal-title":"Sci Total Environ"},{"key":"2026022021220068200_bib21","doi-asserted-by":"crossref","first-page":"110422","DOI":"10.1016\/j.envres.2020.110422","article-title":"Profile of exposures and lung function in adults with asthma: an exposome approach in the EGEA study","volume":"196","author":"Guillien","year":"2021","journal-title":"Environ Res"},{"key":"2026022021220068200_bib22","first-page":"A2137","article-title":"Combined effect of socioeconomic, environmental, and lifestyle factors on asthma: an exposome study in the French Nutrinet-Sant\u00e9 Cohort","volume":"205","author":"Guillien","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"2026022021220068200_bib23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/1471-2458-10-242","article-title":"The Nutrinet-Sant\u00e9 Study: a web-based prospective study on the relationship between nutrition and health and determinants of dietary patterns and nutritional status","volume":"10","author":"Hercberg","year":"2010","journal-title":"BMC Public Health"},{"key":"2026022021220068200_bib24","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1398-9995.2006.01184.x","article-title":"Asthma score: predictive ability and risk factors","volume":"62","author":"Sunyer","year":"2007","journal-title":"Allergy"},{"key":"2026022021220068200_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1183\/09031936.05.00120104","article-title":"Operational definitions of asthma in studies on its aetiology","volume":"26","author":"Pekkanen","year":"2005","journal-title":"Eur Respir J"},{"key":"2026022021220068200_bib26","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jaci.2006.01.011","article-title":"Asthma Control Test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists","volume":"117","author":"Schatz","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"2026022021220068200_bib27","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s11222-016-9670-1","article-title":"Variable selection for model-based clustering using the integrated complete-data likelihood","volume":"27","author":"Marbac","year":"2017","journal-title":"Stat Comput"},{"key":"2026022021220068200_bib28","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.3390\/ijerph18031138","article-title":"The exposome approach to decipher the role of multiple environmental and lifestyle determinants in asthma","volume":"18","author":"Guillien","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"2026022021220068200_bib29","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1016\/j.jaip.2021.02.022","article-title":"Household cleaning and poor asthma control among elderly women","volume":"9","author":"Dumas","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2026022021220068200_bib30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1183\/09031936.00114514","article-title":"A systematic review of socioeconomic position in relation to asthma and allergic diseases","volume":"46","author":"Uphoff","year":"2015","journal-title":"Eur Respir J"},{"key":"2026022021220068200_bib31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.rmed.2019.09.010","article-title":"Low socioeconomic position and neighborhood deprivation are associated with uncontrolled asthma in elderly","volume":"158","author":"Temam","year":"2019","journal-title":"Respir Med"},{"key":"2026022021220068200_bib32","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nri2871","article-title":"Farm living: effects on childhood asthma and allergy","volume":"10","author":"von Mutius","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"2026022021220068200_bib33","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1001\/jama.288.8.963","article-title":"Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age","volume":"288","author":"Ownby","year":"2002","journal-title":"JAMA"},{"key":"2026022021220068200_bib34","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJM200008243430803","article-title":"Siblings, day-care attendance, and the risk of asthma and wheezing during childhood","volume":"343","author":"Ball","year":"2000","journal-title":"N Engl J Med"},{"key":"2026022021220068200_bib35","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1002\/ppul.24961","article-title":"The association between secondhand smoke and childhood asthma: a systematic review and meta-analysis","volume":"55","author":"He","year":"2020","journal-title":"Pediatr Pulmonol"},{"key":"2026022021220068200_bib36","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3390\/nu10080995","article-title":"Breastfeeding and the developmental origins of asthma: current evidence, possible mechanisms, and future research priorities","volume":"10","author":"Miliku","year":"2018","journal-title":"Nutrients"},{"key":"2026022021220068200_bib37","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/archpedi.155.11.1261","article-title":"Breastfeeding and asthma in young children: findings from a population-based study","volume":"155","author":"Dell","year":"2001","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2026022021220068200_bib38","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jaci.2004.07.036","article-title":"Breast-feeding reduces the risk of asthma during the first 4 years of life","volume":"114","author":"Kull","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"2026022021220068200_bib39","doi-asserted-by":"crossref","first-page":"e787","DOI":"10.1542\/peds.2005-1753","article-title":"Breastfeeding does not increase the risk of asthma at 14 years","volume":"117","author":"Burgess","year":"2006","journal-title":"Pediatrics"},{"key":"2026022021220068200_bib40","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/thorax.56.3.192","article-title":"Factors influencing the relation of infant feeding to asthma and recurrent wheeze in childhood","volume":"56","author":"Wright","year":"2001","journal-title":"Thorax"},{"key":"2026022021220068200_bib41","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0140-6736(02)11025-7","article-title":"Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study","volume":"360","author":"Sears","year":"2002","journal-title":"Lancet"},{"key":"2026022021220068200_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1017\/S0007114519000655","article-title":"Association between an individual dietary index based on the British Food Standard Agency Nutrient Profiling System and asthma symptoms","volume":"122","author":"Andrianasolo","year":"2019","journal-title":"Br J Nutr"},{"key":"2026022021220068200_bib43","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1034\/j.1399-3003.2000.15.08.x","article-title":"Relationships of active smoking to asthma and asthma severity in the EGEA study. Epidemiological study on the Genetics and Environment of Asthma","volume":"15","author":"Siroux","year":"2000","journal-title":"Eur Respir J"},{"key":"2026022021220068200_bib44","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s11136-007-9267-4","article-title":"Impact of smoking on asthma symptoms, healthcare resource use, and quality of life outcomes in adults with persistent asthma","volume":"16","author":"Shavit","year":"2007","journal-title":"Qual Life Res"},{"key":"2026022021220068200_bib45","doi-asserted-by":"crossref","first-page":"262","DOI":"10.18176\/jiaci.0316","article-title":"Obesity and asthma: key clinical questions","volume":"29","author":"Garcia-Rio","year":"2019","journal-title":"J Investig Allergol Clin Immunol"},{"key":"2026022021220068200_bib46","doi-asserted-by":"crossref","first-page":"105749","DOI":"10.1016\/j.envint.2020.105749","article-title":"Residential greenspace and lung function up to 24 years of age: the ALSPAC birth cohort","volume":"140","author":"Fuertes","year":"2020","journal-title":"Environ Int"},{"key":"2026022021220068200_bib47","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/ijerph19010512","article-title":"Association between asthma control and exposure to greenness and other outdoor and indoor environmental factors: a longitudinal study on a cohort of asthmatic children","volume":"19","author":"Cilluffo","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"2026022021220068200_bib48","author":"Global Initiative for Asthma","year":"2018"},{"key":"2026022021220068200_bib49","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11882-019-0878-y","article-title":"Novel insights on sex-related differences in asthma","volume":"19","author":"Zhang","year":"2019","journal-title":"Curr Allergy Asthma Rep"},{"key":"2026022021220068200_bib50","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/aje\/kww016","article-title":"Comparison of dietary intakes between a large online cohort study (Etude NutriNet-Sant\u00e9) and a nationally representative cross-sectional study (Etude Nationale Nutrition Sant\u00e9) in France: addressing the issue of generalizability in E-epidemiology","volume":"184","author":"Andreeva","year":"2016","journal-title":"Am J Epidemiol"}],"updated-by":[{"DOI":"10.1164\/rccm.v208erratum4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000}}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/206\/10\/1208\/67000825\/ajrccm_206_10_1208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/206\/10\/1208\/67000825\/ajrccm_206_10_1208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:22:13Z","timestamp":1771640533000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/206\/10\/1208\/8491753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":50,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,11,15]]},"published-print":{"date-parts":[[2022,11,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202205-0865oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11]]},"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}