{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:51:07Z","timestamp":1781218267686,"version":"3.54.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"crossref","award":["2017\/21554-5"],"award-info":[{"award-number":["2017\/21554-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The National Council for Scientific and Technological Development","award":["#309180\/2021"],"award-info":[{"award-number":["#309180\/2021"]}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2017\/21554-5"],"award-info":[{"award-number":["2017\/21554-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The National Council for Scientific and Technological Development","award":["#309180\/2021"],"award-info":[{"award-number":["#309180\/2021"]}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"DOI":"10.1164\/rccm.202208-1583le","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T15:03:46Z","timestamp":1681398226000},"page":"616-618","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Thiamine on Clinical Outcomes in Septic Shock Patients: A Randomized, Double-Blinded Pilot Study"],"prefix":"10.1093","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-5756","authenticated-orcid":false,"given":"Amanda G.","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nara A.","family":"Costa","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Federal University of Goi\u00e1s (UFG), Goi\u00e2nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9fanie C. P.","family":"Amancio","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina P.","family":"Okoshi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo A. M.","family":"Zornoff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula S.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos F.","family":"Minicucci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio A. R.","family":"de Paiva","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertha F.","family":"Polegato","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"2026012204404806800_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"2026012204404806800_bib2","doi-asserted-by":"crossref","first-page":"805199","DOI":"10.3389\/fmed.2021.805199","article-title":"Insights into thiamine supplementation in patients with septic shock","volume":"8","author":"Costa","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"2026012204404806800_bib3","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.21037\/jtd.2019.12.82","article-title":"Thiamine (vitamin B1) in septic shock: a targeted therapy","volume":"12","author":"Moskowitz","year":"2020","journal-title":"J Thorac Dis"},{"key":"2026012204404806800_bib4","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1097\/CCM.0000000000004394","article-title":"Association between IV thiamine and mortality in patients with septic shock: a nationwide observational study","volume":"48","author":"Miyamoto","year":"2020","journal-title":"Crit Care Med"},{"key":"2026012204404806800_bib5","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1097\/CCM.0000000000003311","article-title":"Effect of thiamine administration on lactate clearance and mortality in patients with septic shock","volume":"46","author":"Woolum","year":"2018","journal-title":"Crit Care Med"},{"key":"2026012204404806800_bib6","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/CCM.0000000000001572","article-title":"Randomized, double-blind, placebo-controlled trial of thiamine as a metabolic resuscitator in septic shock: a pilot study","volume":"44","author":"Donnino","year":"2016","journal-title":"Crit Care Med"},{"key":"2026012204404806800_bib7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s12871-020-01195-4","article-title":"Effects of thiamine on vasopressor requirements in patients with septic shock: a prospective randomized controlled trial","volume":"20","author":"Petsakul","year":"2020","journal-title":"BMC Anesthesiol"},{"key":"2026012204404806800_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/0103-507X.20190008","article-title":"Mortality due to sepsis in Brazil in a real scenario: the Brazilian ICUs project","volume":"31","author":"Lobo","year":"2019","journal-title":"Rev Bras Ter Intensiva"},{"key":"2026012204404806800_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jcrc.2013.12.004","article-title":"Serum thiamine concentration and oxidative stress as predictors of mortality in patients with septic shock","volume":"29","author":"Costa","year":"2014","journal-title":"J Crit Care"},{"key":"2026012204404806800_bib10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jcrc.2017.08.022","article-title":"Thiamine in septic shock patients with alcohol use disorders: an observational pilot study","volume":"43","author":"Holmberg","year":"2018","journal-title":"J Crit Care"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/208\/5\/616\/66425632\/ajrccm_208_5_616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/208\/5\/616\/66425632\/ajrccm_208_5_616.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:41:06Z","timestamp":1769074866000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/208\/5\/616\/8426894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,9,1]]},"published-print":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202208-1583le","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9]]},"published":{"date-parts":[[2023,9,1]]},"assertion":[{"value":"2023-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}