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However, the mechanisms for resolving eosinophilic allergic lung inflammation triggered by inhaled allergens have not been fully elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our objectives were to investigate the cellular mechanism of tissue-resident macrophages involved in the resolution process of eosinophilic lung inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>For the study, we used the institutional review board\u2013approved protocol for human subsegmental bronchoprovocation with allergen, mouse models for allergic lung inflammation, and novel transgenic mice, including a conditional CCL26 knockout. The samples were analyzed using mass cytometry, single-cell RNA sequencing, and biophysical and immunological analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>We compared alveolar macrophage (AM) subsets in the BAL before and after allergen provocation. In response to provocation with inhaled allergens, the subsets of AMs are dynamically changed in humans and mice. In the steady state, the AM subset expressing CX3CR1 is a relatively small fraction in bronchoalveolar space and lung tissue but drastically increases after allergen challenges. This subset presents unique patterns of gene expression compared with classical AMs, expressing high C1q family genes. CX3CR1 \u00a0+ macrophages are activated by airway epithelial cell\u2013derived CCL26 via a receptor\u2013ligand interaction. The binding of CCL26 to the CX3CR1 \u00a0+ receptor induces CX3CR1 \u00a0+ macrophages to secrete C1q, subsequently facilitating the clearance of eosinophils. Furthermore, the depletion of CX3CR1 macrophages or CCL26 in airway epithelial cells delays the resolution of allergic lung inflammation displaying prolonged tissue eosinophilia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that the CCL26\u2013CX3CR1 pathway is pivotal in resolving eosinophilic allergic lung inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202209-1670oc","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T10:14:25Z","timestamp":1676456065000},"page":"1451-1463","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":23,"title":["CX3CR1 \u00a0+ Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26"],"prefix":"10.1093","volume":"207","author":[{"given":"Hyung-Geun","family":"Moon","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Mee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalees","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of 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