{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:52:51Z","timestamp":1787698371794,"version":"build-2784847793"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":1086,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2,15]]},"DOI":"10.1164\/rccm.202209-1833ed","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T16:06:23Z","timestamp":1664381183000},"page":"381-382","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":3,"title":["Remodeling Phenotypes Take Center Stage in the Prediction of Preschool Wheeze Attacks"],"prefix":"10.1093","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5192-6418","authenticated-orcid":false,"given":"Sejal","family":"Saglani","sequence":"first","affiliation":[{"name":"National Heart & Lung Institute, Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Baraldo","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova and Padova City Hospital, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"2026012204482104800_bib1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1164\/rccm.200702-212OC","article-title":"Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers","volume":"176","author":"Saglani","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204482104800_bib2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1164\/rccm.200602-189OC","article-title":"Epithelial damage and angiogenesis in the airways of children with asthma","volume":"174","author":"Barbato","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204482104800_bib3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1183\/09031936.00168210","article-title":"Noneosinophilic asthma in children: relation with airway remodelling","volume":"38","author":"Baraldo","year":"2011","journal-title":"Eur Respir J"},{"key":"2026012204482104800_bib4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1164\/rccm.201411-1958OC","article-title":"Airway remodeling in preschool children with severe recurrent wheeze","volume":"192","author":"Lezmi","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204482104800_bib5","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.jaci.2012.08.044","article-title":"Increased airway smooth muscle in preschool wheezers who have asthma at school age","volume":"131","author":"O\u2019Reilly","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"2026012204482104800_bib6","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1165\/rcmb.2018-0009OC","article-title":"Clinical and pathologic factors predicting future asthma in wheezing children: a longitudinal study","volume":"59","author":"Bonato","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204482104800_bib7","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.jaip.2017.02.003","article-title":"Neutrophilic steroid-refractory recurrent wheeze and eosinophilic steroid-refractory asthma in children","volume":"5","author":"Guiddir","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2026012204482104800_bib8","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1164\/rccm.202205-0913OC","article-title":"Bronchial remodeling-based latent class analysis predicts exacerbations in severe preschool wheezers","volume":"207","author":"Fayon","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204482104800_bib9","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1164\/rccm.201511-2204ED","article-title":"Asthma: airways that are hyperactive by design","volume":"193","author":"Oliver","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204482104800_bib10","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.3390\/jpm11111229","article-title":"Airway wall remodeling in childhood asthma: a personalized perspective from cell type-specific biology","volume":"11","author":"Fang","year":"2021","journal-title":"J Pers Med"},{"key":"2026012204482104800_bib11","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1164\/rccm.202001-0194OC","article-title":"Fetal origins of asthma: a longitudinal study from birth to age 36 years","volume":"202","author":"Guerra","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204482104800_bib12","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jaci.2021.03.027","article-title":"Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers","volume":"148","author":"Beaufils","year":"2021","journal-title":"J Allergy Clin Immunol"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/207\/4\/381\/66437577\/ajrccm_207_4_381.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/207\/4\/381\/66437577\/ajrccm_207_4_381.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:48:29Z","timestamp":1769075309000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/207\/4\/381\/8428216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2,15]]},"published-print":{"date-parts":[[2023,2,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202209-1833ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2]]},"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2023-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}