{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:23:27Z","timestamp":1793726607992,"version":"4.6.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Health\u223cHolland","award":["10.2.17.181PPS"],"award-info":[{"award-number":["10.2.17.181PPS"]}]},{"DOI":"10.13039\/100016036","name":"Health\u223cHolland","doi-asserted-by":"publisher","award":["10.2.17.181PPS"],"award-info":[{"award-number":["10.2.17.181PPS"]}],"id":[{"id":"10.13039\/100016036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Lung ultrasound (LUS) is a promising tool for diagnosis of acute respiratory distress syndrome (ARDS), but adequately sized studies with external validation are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop and validate a data-driven LUS score for diagnosis of ARDS and compare its performance with that of chest radiography (CXR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter prospective observational study included invasively ventilated ICU patients who were divided into a derivation cohort and a validation cohort. Three raters scored ARDS according to the Berlin criteria, resulting in a classification of \u201ccertain no ARDS,\u201d or \u201ccertain ARDS\u201d when experts agreed or \u201cuncertain ARDS\u201d when evaluations conflicted. Uncertain cases were classified in a consensus meeting. Results of a 12-region LUS exam were used in a logistic regression model to develop the LUS-ARDS score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Three hundred twenty-four (16% certain ARDS) and 129 (34% certain ARDS) patients were included in the derivation cohort and the validation cohort, respectively. With an ARDS diagnosis by the expert panel as the reference test, the LUS-ARDS score, including the left and right LUS aeration scores and anterolateral pleural line abnormalities, had an area under the receiver operating characteristic (ROC) curve of 0.90 (95% confidence interval [CI], 0.85\u20130.95) in certain patients of the derivation cohort and 0.80 (95% CI, 0.72\u20130.87) in all patients of the validation cohort. Within patients who had imaging\u2013gold standard chest computed tomography available, diagnostic accuracy of eight independent CXR readers followed the ROC curve of the LUS-ARDS score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The LUS-ARDS score can be used to accurately diagnose ARDS also after external validation. The LUS-ARDS score may be a useful adjunct to a diagnosis of ARDS after further validation, as it showed performance comparable with that of the current practice with experienced CXR readers but more objectifiable diagnostic accuracy at each cutoff.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202210-1882oc","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T10:14:25Z","timestamp":1676456065000},"page":"1591-1601","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":94,"title":["Lung Ultrasound Prediction Model for Acute Respiratory Distress Syndrome: A Multicenter Prospective Observational Study"],"prefix":"10.1093","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9938-6035","authenticated-orcid":false,"given":"Marry R.","family":"Smit","sequence":"first","affiliation":[{"name":"Department of Intensive Care, Amsterdam University Medical Center (UMC), location University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-4465","authenticated-orcid":false,"given":"Laura A.","family":"Hagens","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam University Medical Center (UMC), location University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9147-891X","authenticated-orcid":false,"given":"Nanon F. L.","family":"Heijnen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Maastricht UMC+, Maastricht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Pisani","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam University Medical Center (UMC), location University of Amsterdam, Amsterdam, the Netherlands"},{"name":"Mahidol\u2013Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand"},{"name":"Department of Anesthesia and Intensive Care, Miulli Regional Hospital, Acquaviva delle Fonti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G. V.","family":"Cherpanath","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam University Medical Center (UMC), location University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave A.","family":"Dongelmans","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam University Medical Center (UMC), location University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7499-076X","authenticated-orcid":false,"given":"Harm-Jan S.","family":"de Grooth","sequence":"additional","affiliation":[{"name":"Intensive Care, Amsterdam UMC, locatie Vrije Universiteit Amsterdam, Amsterdam, Nederland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Pierrakos","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam University Medical Center (UMC), location University of Amsterdam, Amsterdam, the Netherlands"},{"name":"Department of Intensive Care, Brugmann University Hospital, Free University of Brussels, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter Roel","family":"Tuinman","sequence":"additional","affiliation":[{"name":"Intensive Care, Amsterdam UMC, locatie Vrije Universiteit Amsterdam, Amsterdam, Nederland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Zimatore","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam University Medical Center (UMC), location University of Amsterdam, Amsterdam, the Netherlands"},{"name":"Intensive Care Unit, Emergency and Organ Transplantation, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederique","family":"Paulus","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam University Medical Center (UMC), location University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny M.","family":"Schnabel","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Maastricht UMC+, Maastricht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus J.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam University Medical Center (UMC), location University of Amsterdam, Amsterdam, the Netherlands"},{"name":"Mahidol\u2013Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand"},{"name":"Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis C. 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