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However, it is not clear if such events independently predict worse respiratory outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine if analysis of cardiorespiratory monitoring data can predict unfavorable respiratory outcomes at 40\u2009weeks postmenstrual age (PMA) and other outcomes, such as bronchopulmonary dysplasia at 36\u2009weeks PMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Prematurity-related Ventilatory Control (Pre-Vent) study was an observational multicenter prospective cohort study including infants born at &amp;lt;29\u2009weeks of gestation with continuous cardiorespiratory monitoring. The primary outcome was either \u201cfavorable\u201d (alive and previously discharged or inpatient and off respiratory medications\/O2\/support at 40 wk PMA) or \u201cunfavorable\u201d (either deceased or inpatient\/previously discharged on respiratory medications\/O2\/support at 40 wk PMA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>A total of 717 infants were evaluated (median birth weight, 850\u2009g; gestation, 26.4 wk), 53.7% of whom had a favorable outcome and 46.3% of whom had an unfavorable outcome. Physiologic data predicted unfavorable outcome, with accuracy improving with advancing age (area under the curve, 0.79 at Day 7, 0.85 at Day 28 and 32 wk PMA). The physiologic variable that contributed most to prediction was intermittent hypoxemia with oxygen saturation as measured by pulse oximetry &amp;lt;90%. Models with clinical data alone or combining physiologic and clinical data also had good accuracy, with areas under the curve of 0.84\u20130.85 at Days 7 and 14 and 0.86\u20130.88 at Day 28 and 32\u2009weeks PMA. Intermittent hypoxemia with oxygen saturation as measured by pulse oximetry &amp;lt;80% was the major physiologic predictor of severe bronchopulmonary dysplasia and death or mechanical ventilation at 40\u2009weeks PMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Physiologic data are independently associated with unfavorable respiratory outcome in extremely preterm infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202210-1971oc","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T09:00:27Z","timestamp":1684832427000},"page":"79-97","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":54,"title":["Cardiorespiratory Monitoring Data to Predict Respiratory Outcomes in Extremely Preterm Infants"],"prefix":"10.1093","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-9092","authenticated-orcid":false,"given":"Namasivayam","family":"Ambalavanan","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra E.","family":"Weese-Mayer","sequence":"additional","affiliation":[{"name":"Ann & Robert H. 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Lurie Children\u2019s Hospital of Chicago, Stanley Manne Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-2439","authenticated-orcid":false,"given":"Richard J.","family":"Martin","sequence":"additional","affiliation":[{"name":"University Hospitals Rainbow Babies & Children\u2019s Hospital, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliann M.","family":"Di Fiore","sequence":"additional","affiliation":[{"name":"University Hospitals Rainbow Babies & Children\u2019s Hospital, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premananda","family":"Indic","sequence":"additional","affiliation":[{"name":"University of Texas at Tyler, Tyler, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine in St. Louis, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaleh","family":"Dormishian","sequence":"additional","affiliation":[{"name":"University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy N.","family":"Krahn","sequence":"additional","affiliation":[{"name":"University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Qiu","sequence":"additional","affiliation":[{"name":"University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis A.","family":"Dennery","sequence":"additional","affiliation":[{"name":"Brown University School of Medicine, Providence, Rhode Island; 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