{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:30:50Z","timestamp":1787682650149,"version":"build-2784847793"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":966,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI 111820"],"award-info":[{"award-number":["R01 AI 111820"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["101BX004299"],"award-info":[{"award-number":["101BX004299"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["COOK20L0"],"award-info":[{"award-number":["COOK20L0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["5P30 CA68485-19"],"award-info":[{"award-number":["5P30 CA68485-19"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI 111820"],"award-info":[{"award-number":["R01 AI 111820"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["101BX004299"],"award-info":[{"award-number":["101BX004299"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["COOK20L0"],"award-info":[{"award-number":["COOK20L0"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["5P30 CA68485-19"],"award-info":[{"award-number":["5P30 CA68485-19"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Type 2 inflammation has been described in people with cystic fibrosis (CF). Whether loss of CFTR (cystic fibrosis transmembrane conductance regulator) function contributes directly to a type 2 inflammatory response has not been fully defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The potent alarmin IL-33 has emerged as a critical regulator of type 2 inflammation. We tested the hypothesis that CFTR deficiency increases IL-33 expression and\/or release and deletion of IL-33 reduces allergen-induced inflammation in the CF lung.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Human airway epithelial cells (AECs) grown from non-CF and CF cell lines and Cftr \u00a0+\/+ and Cftr \u00a0\u2212\/\u2212 mice were used in this study. Pulmonary inflammation in Cftr \u00a0+\/+ and Cftr \u00a0\u2212\/\u2212 mice with and without IL-33 or ST2 (IL-1 receptor-like 1) germline deletion was determined by histological analysis, BAL, and cytokine analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>After allergen challenge, both CF human AECs and Cftr \u00a0\u2212\/\u2212 mice had increased IL-33 expression compared with control AECs and Cftr \u00a0+\/+ mice, respectively. DUOX1 (dual oxidase 1) expression was increased in CF human AECs and Cftr \u00a0\u2212\/\u2212 mouse lungs compared with control AECs and lungs from Cftr \u00a0+\/+ mice and was necessary for the increased IL-33 release in Cftr \u00a0\u2212\/\u2212 mice compared with Cftr \u00a0+\/+ mice. IL-33 stimulation of Cftr \u00a0\u2212\/\u2212 CD4+ T cells resulted in increased type 2 cytokine production compared with Cftr+\/+ CD4+ T cells. Deletion of IL-33 or ST2 decreased both type 2 inflammation and neutrophil recruitment in Cftr \u00a0\u2212\/\u2212 mice compared with Cftr \u00a0+\/+ mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Absence of CFTR reprograms airway epithelial IL-33 release and licenses IL-33\u2013dependent inflammation. Modulation of the IL-33\/ST2 axis represents a novel therapeutic target in CF type 2\u2013high and neutrophilic inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202211-2096oc","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T16:29:06Z","timestamp":1679588946000},"page":"1486-1497","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":24,"title":["Cystic Fibrosis Reprograms Airway Epithelial IL-33 Release and Licenses IL-33\u2013Dependent Inflammation"],"prefix":"10.1093","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1152-4454","authenticated-orcid":false,"given":"Daniel P.","family":"Cook","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Rusznak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline-Yvonne","family":"Cephus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine N.","family":"Gibson-Corley","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliy V.","family":"Polosukhin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison E.","family":"Norlander","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn C.","family":"Newcomb","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-9015","authenticated-orcid":false,"given":"David A.","family":"Stoltz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"R. Stokes","family":"Peebles","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"2026012220022079800_bib1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJMra1300109","article-title":"Origins of cystic fibrosis lung disease","volume":"372","author":"Stoltz","year":"2015","journal-title":"N Engl J Med"},{"key":"2026012220022079800_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1164\/rccm.201011-1892OC","article-title":"Infection, inflammation, and lung function decline in infants with cystic fibrosis","volume":"184","author":"Pillarisetti","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012220022079800_bib3","first-page":"939","article-title":"Cystic fibrosis lung inflammation: early, sustained, and severe","volume":"151","author":"Cantin","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012220022079800_bib4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jcf.2015.03.003","article-title":"Inflammation in cystic fibrosis lung disease: pathogenesis and therapy","volume":"14","author":"Cantin","year":"2015","journal-title":"J Cyst Fibros"},{"key":"2026012220022079800_bib5","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1002\/ppul.24129","article-title":"Inflammation in cystic fibrosis: an update","volume":"53","author":"Roesch","year":"2018","journal-title":"Pediatr Pulmonol"},{"key":"2026012220022079800_bib6","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1164\/rccm.201708-1616OC","article-title":"Infection is not required for mucoinflammatory lung disease in CFTR-knockout ferrets","volume":"197","author":"Rosen","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012220022079800_bib7","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/thx.2010.139493","article-title":"Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis","volume":"66","author":"Ranganathan","year":"2011","journal-title":"Thorax"},{"key":"2026012220022079800_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/pai.13619","article-title":"Type 2 inflammation in cystic fibrosis: new insights","volume":"33","author":"Manti","year":"2022","journal-title":"Pediatr Allergy Immunol"},{"key":"2026012220022079800_bib9","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.4049\/jimmunol.177.8.5186","article-title":"Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulator","volume":"177","author":"Allard","year":"2006","journal-title":"J Immunol"},{"key":"2026012220022079800_bib10","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jaci.2005.09.023","article-title":"Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis","volume":"117","author":"Hartl","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"2026012220022079800_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/(SICI)1099-0496(199902)27:2<74::AID-PPUL2>3.0.CO;2-L","article-title":"Increased antigen-specific Th-2 response in allergic bronchopulmonary aspergillosis (ABPA) in patients with cystic fibrosis","volume":"27","author":"Skov","year":"1999","journal-title":"Pediatr Pulmonol"},{"key":"2026012220022079800_bib12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1164\/rccm.201206-1150OC","article-title":"A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection","volume":"187","author":"Tiringer","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012220022079800_bib13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nrd2660","article-title":"The IL-33\/ST2 pathway: therapeutic target and novel biomarker","volume":"7","author":"Kakkar","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"2026012220022079800_bib14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nri.2017.118","article-title":"TH2 cell development and function","volume":"18","author":"Walker","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"2026012220022079800_bib15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1073\/pnas.0606854104","article-title":"IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo","volume":"104","author":"Carriere","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026012220022079800_bib16","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.jaci.2015.10.003","article-title":"Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses","volume":"137","author":"Hristova","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"2026012220022079800_bib17","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/cmi.2010.3","article-title":"The enigmatic processing and secretion of interleukin-33","volume":"7","author":"Zhao","year":"2010","journal-title":"Cell Mol Immunol"},{"key":"2026012220022079800_bib18","first-page":"e136166","article-title":"Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease","volume":"6","author":"Katz-Kiriakos","year":"2021","journal-title":"JCI Insight"},{"key":"2026012220022079800_bib19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.coi.2014.09.004","article-title":"IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy","volume":"31","author":"Cayrol","year":"2014","journal-title":"Curr Opin Immunol"},{"key":"2026012220022079800_bib20","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/imr.12619","article-title":"Interleukin-33 (IL-33): a nuclear cytokine from the IL-1 family","volume":"281","author":"Cayrol","year":"2018","journal-title":"Immunol Rev"},{"key":"2026012220022079800_bib21","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jaci.2012.10.019","article-title":"IL-33 is expressed in epithelia from patients with cystic fibrosis and potentiates neutrophil recruitment","volume":"131","author":"Roussel","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"2026012220022079800_bib22","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1183\/09031936.00046614","article-title":"Differential expression of IL-33 and HMGB1 in the lungs of stable cystic fibrosis patients","volume":"44","author":"Tiringer","year":"2014","journal-title":"Eur Respir J"},{"key":"2026012220022079800_bib23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fcell.2015.00087","article-title":"The TAK1\u2192IKK\u03b2\u2192TPL2\u2192MKK1\/mkk2 signaling cascade regulates IL-33 expression in cystic fibrosis airway epithelial cells following infection by Pseudomonas aeruginosa","volume":"3","author":"Farias","year":"2016","journal-title":"Front Cell Dev Biol"},{"key":"2026012220022079800_bib24","doi-asserted-by":"crossref","first-page":"e88811","DOI":"10.1172\/jci.insight.88811","article-title":"DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma","volume":"1","author":"Habibovic","year":"2016","journal-title":"JCI Insight"},{"key":"2026012220022079800_bib25","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.4049\/jimmunol.1700605","article-title":"The PGI2 analog cicaprost inhibits IL-33-induced Th2 responses, IL-2 production, and CD25 expression in mouse CD4+ T cells","volume":"201","author":"Zhou","year":"2018","journal-title":"J Immunol"},{"key":"2026012220022079800_bib26","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1183\/09031936.99.14511369","article-title":"Cytokine expression in bronchial biopsies of cystic fibrosis patients with and without acute exacerbation","volume":"14","author":"Wojnarowski","year":"1999","journal-title":"Eur Respir J"},{"key":"2026012220022079800_bib27","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1073\/pnas.1914912117","article-title":"Cystic fibrosis carriers are at increased risk for a wide range of cystic fibrosis-related conditions","volume":"117","author":"Miller","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026012220022079800_bib28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1439-0507.2011.02130.x","article-title":"Link between CFTR mutations and ABPA: a systematic review and meta-analysis","volume":"55","author":"Agarwal","year":"2012","journal-title":"Mycoses"},{"key":"2026012220022079800_bib29","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.immuni.2015.06.006","article-title":"Interleukin-33 in tissue homeostasis, injury, and inflammation","volume":"42","author":"Molofsky","year":"2015","journal-title":"Immunity"},{"key":"2026012220022079800_bib30","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1007\/s004240100642","article-title":"Relationship between IkappaBalpha deficiency, NFkappaB activity and interleukin-8 production in CF human airway epithelial cells","volume":"443","author":"Tabary","year":"2001","journal-title":"Pflugers Arch"},{"key":"2026012220022079800_bib31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1385\/CRIAI:23:1:005","article-title":"The role of inflammation in the pathophysiology of CF lung disease","volume":"23","author":"Chmiel","year":"2002","journal-title":"Clin Rev Allergy Immunol"},{"key":"2026012220022079800_bib32","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1164\/rccm.200607-1029OC","article-title":"A novel host defense system of airways is defective in cystic fibrosis","volume":"175","author":"Moskwa","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012220022079800_bib33","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.freeradbiomed.2011.02.013","article-title":"Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions","volume":"50","author":"Lorentzen","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"2026012220022079800_bib34","first-page":"621","article-title":"Potential role of the \u201cNADPH oxidases\u201d (NOX\/DUOX) family in cystic fibrosis","volume":"66","author":"Pongnimitprasert","year":"2008","journal-title":"Ann Biol Clin (Paris)"},{"key":"2026012220022079800_bib35","first-page":"175","article-title":"Airway surface liquid pH and innate defense by the NADPH oxidase","volume":"30","author":"Fischer","year":"2007","journal-title":"Pediatr Pulmonol"},{"key":"2026012220022079800_bib36","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1089\/ars.2009.2558","article-title":"Mechanisms and function of DUOX in epithelia of the lung","volume":"11","author":"Fischer","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"2026012220022079800_bib37","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1165\/rcmb.2019-0170OC","article-title":"The transient receptor potential channel vanilloid 1 is critical in innate airway epithelial responses to protease allergens","volume":"63","author":"Schiffers","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012220022079800_bib38","doi-asserted-by":"crossref","first-page":"10202","DOI":"10.1074\/jbc.M410617200","article-title":"Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia","volume":"280","author":"Ribeiro","year":"2005","journal-title":"J Biol Chem"},{"key":"2026012220022079800_bib39","doi-asserted-by":"crossref","first-page":"17798","DOI":"10.1074\/jbc.M410618200","article-title":"Chronic airway infection\/inflammation induces a Ca2+i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia","volume":"280","author":"Ribeiro","year":"2005","journal-title":"J Biol Chem"},{"key":"2026012220022079800_bib40","doi-asserted-by":"crossref","first-page":"E2086","DOI":"10.1073\/pnas.1613546114","article-title":"Synergy of cAMP and calcium signaling pathways in CFTR regulation","volume":"114","author":"Bozoky","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026012220022079800_bib41","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.4049\/jimmunol.1800076","article-title":"Dysregulated calcium homeostasis in cystic fibrosis neutrophils leads to deficient antimicrobial responses","volume":"201","author":"Robledo-Avila","year":"2018","journal-title":"J Immunol"},{"key":"2026012220022079800_bib42","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.4049\/jimmunol.1900234","article-title":"Ablation of IL-33 suppresses Th2 responses but is accompanied by sustained mucus obstruction in the Scnn1b transgenic mouse model","volume":"204","author":"Lewis","year":"2020","journal-title":"J Immunol"},{"key":"2026012220022079800_bib43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/mi.2017.32","article-title":"Novel protective mechanism for interleukin-33 at the mucosal barrier during influenza-associated bacterial superinfection","volume":"11","author":"Robinson","year":"2018","journal-title":"Mucosal Immunol"},{"key":"2026012220022079800_bib44","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molimm.2016.03.004","article-title":"Interleukin-33 facilitates neutrophil recruitment and bacterial clearance in S. aureus-caused peritonitis","volume":"72","author":"Lan","year":"2016","journal-title":"Mol Immunol"},{"key":"2026012220022079800_bib45","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nm.2156","article-title":"Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection","volume":"16","author":"Alves-Filho","year":"2010","journal-title":"Nat Med"},{"key":"2026012220022079800_bib46","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3389\/fimmu.2019.00364","article-title":"IL33: roles in allergic inflammation and therapeutic perspectives","volume":"10","author":"Chan","year":"2019","journal-title":"Front Immunol"},{"key":"2026012220022079800_bib47","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1164\/rccm.201407-1381OC","article-title":"Regulatory T-cell impairment in cystic fibrosis patients with chronic pseudomonas infection","volume":"191","author":"Hector","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012220022079800_bib48","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.jaci.2017.01.015","article-title":"IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs","volume":"140","author":"Chen","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2026012220022079800_bib49","doi-asserted-by":"crossref","first-page":"14919","DOI":"10.1038\/ncomms14919","article-title":"IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population","volume":"8","author":"Nascimento","year":"2017","journal-title":"Nat Commun"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/207\/11\/1486\/66436024\/ajrccm_207_11_1486.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/207\/11\/1486\/66436024\/ajrccm_207_11_1486.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T01:03:12Z","timestamp":1769130192000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/207\/11\/1486\/8428018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":49,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,6,1]]},"published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202211-2096oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,6,1]]},"assertion":[{"value":"2022-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}