{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:21:11Z","timestamp":1792023671916,"version":"4.4.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":813,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Swedish Heart and Lung Foundation"},{"DOI":"10.13039\/501100004885","name":"Ume\u00e5 University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004885","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Respiratory Society"},{"name":"VISARE NORR Fund Northern County Councils Regional Federation"},{"DOI":"10.13039\/501100009772","name":"Norrbotten County Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009772","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Heart and Lung Foundation"},{"DOI":"10.13039\/501100004885","name":"Ume\u00e5 University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004885","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Respiratory Society"},{"name":"VISARE NORR Fund Northern County Councils Regional Federation"},{"DOI":"10.13039\/501100009772","name":"Norrbotten County Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009772","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Spirometry is essential for diagnosis and assessment of prognosis in patients with chronic obstructive pulmonary disease (COPD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify FEV1 trajectories and their determinants on the basis of annual spirometry measurements among individuals with and without airway obstruction (AO) and to assess mortality in relation to trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 2002 through 2004, individuals with AO (FEV1\/VC\u2009&amp;lt;\u20090.70, n\u2009=\u2009993) and age- and sex-matched nonobstructive (NO) referents were recruited from population-based cohorts. Annual spirometry until 2014 was used in joint-survival latent-class mixed models to identify lung function trajectories. Mortality data were collected during 15\u2009years of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Three trajectories were identified among the subjects with AO and two among the NO referents. Trajectory membership was driven by baseline FEV1% predicted (FEV1%pred) in both groups and also by pack-years in subjects with AO and current smoking in NO referents. Longitudinal FEV1%pred depended on baseline FEV1%pred, pack-years, and obesity. The trajectories were distributed as follows: among individuals with AO, 79.6% in AO trajectory 1 (FEV1 high with normal decline), 12.8% in AO trajectory 2 (FEV1 high with rapid decline), and 7.7% in AO trajectory 3 (FEV1 low with normal decline) (mean, 27, 72, and 26\u2009ml\/yr, respectively) and, among NO referents, 96.7% in NO trajectory 1 (FEV1 high with normal decline) and 3.3% in NO trajectory 2 (FEV1 high with rapid decline) (mean, 34 and 173\u2009ml\/yr, respectively). Hazard for death was increased for AO trajectories 2 (hazard ratio [HR], 1.56) and 3 (HR, 3.45) versus AO trajectory 1 and for NO trajectory 2 (HR, 2.99) versus NO trajectory 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Three different FEV1 trajectories were identified among subjects with AO and two among NO referents, with different outcomes in terms of FEV1 decline and mortality. The FEV1 trajectories among subjects with AO and the relationship between low FVC and trajectory outcome are of particular clinical interest.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202211-2166oc","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T17:23:21Z","timestamp":1689614601000},"page":"1063-1074","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":28,"title":["Lung Function Trajectories and Associated Mortality among Adults with and without Airway Obstruction"],"prefix":"10.1093","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0553-8067","authenticated-orcid":false,"given":"Helena","family":"Backman","sequence":"first","affiliation":[{"name":"Section for Sustainable Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-7347","authenticated-orcid":false,"given":"Anders","family":"Blomberg","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1524-0851","authenticated-orcid":false,"given":"Anders","family":"Lundquist","sequence":"additional","affiliation":[{"name":"Department of Statistics, Ume\u00e5 School of Business, Economics and Statistics (USBE), Ume\u00e5 University, Ume\u00e5, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5948-6880","authenticated-orcid":false,"given":"Viktor","family":"Strandkvist","sequence":"additional","affiliation":[{"name":"Department of Health and Technology, Lule\u00e5 University of Technology, Lule\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0473-9227","authenticated-orcid":false,"given":"Sami","family":"Sawalha","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-479X","authenticated-orcid":false,"given":"Ulf","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3434-988X","authenticated-orcid":false,"given":"Jonas","family":"Eriksson-Str\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1630-3167","authenticated-orcid":false,"given":"Linnea","family":"Hedman","sequence":"additional","affiliation":[{"name":"Section for Sustainable Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-3838","authenticated-orcid":false,"given":"Caroline","family":"Stridsman","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2358-8754","authenticated-orcid":false,"given":"Eva","family":"R\u00f6nmark","sequence":"additional","affiliation":[{"name":"Section for Sustainable Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-7471","authenticated-orcid":false,"given":"Anne","family":"Lindberg","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"2026012204332282600_bib1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S2213-2600(21)00511-7","article-title":"Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis","volume":"10","author":"Adeloye","year":"2022","journal-title":"Lancet Respir Med"},{"key":"2026012204332282600_bib2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1164\/rccm.202301-0106PP","article-title":"Global Initiative for Chronic Obstructive Lung Disease 2023 report: GOLD executive summary","volume":"207","author":"Agust\u00ed","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204332282600_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.amjmed.2006.08.002","article-title":"The value of forced expiratory volume in 1 second decline in the assessment of chronic obstructive pulmonary disease progression","volume":"119","author":"Wise","year":"2006","journal-title":"Am J Med"},{"key":"2026012204332282600_bib4","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1136\/bmj.1.6077.1645","article-title":"The natural history of chronic airflow obstruction","volume":"1","author":"Fletcher","year":"1977","journal-title":"BMJ"},{"key":"2026012204332282600_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/resp.12589","article-title":"Natural history of COPD: focusing on change in FEV1","volume":"21","author":"Vestbo","year":"2016","journal-title":"Respirology"},{"key":"2026012204332282600_bib6","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1056\/NEJMoa1105482","article-title":"Changes in forced expiratory volume in 1 second over time in COPD","volume":"365","author":"Vestbo","year":"2011","journal-title":"N Engl J Med"},{"key":"2026012204332282600_bib7","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.2147\/COPD.S278981","article-title":"Characteristics associated with accelerated lung function decline in a primary care population with chronic obstructive pulmonary disease","volume":"15","author":"Whittaker","year":"2020","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2026012204332282600_bib8","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1378\/chest.14-2535","article-title":"Determinants of underdiagnosis of COPD in national and international surveys","volume":"148","author":"Lamprecht","year":"2015","journal-title":"Chest"},{"key":"2026012204332282600_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1411532","article-title":"Lung-function trajectories leading to chronic obstructive pulmonary disease","volume":"373","author":"Lange","year":"2015","journal-title":"N Engl J Med"},{"key":"2026012204332282600_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1164\/rccm.201911-2115OC","article-title":"Lung function trajectories leading to chronic obstructive pulmonary disease as predictors of exacerbations and mortality","volume":"202","author":"Marott","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204332282600_bib11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S2213-2600(18)30100-0","article-title":"Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life","volume":"6","author":"Bui","year":"2018","journal-title":"Lancet Respir Med"},{"key":"2026012204332282600_bib12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.amjmed.2019.06.049","article-title":"Adult life-course trajectories of lung function and the development of emphysema: the CARDIA Lung Study","volume":"133","author":"Washko","year":"2020","journal-title":"Am J Med"},{"key":"2026012204332282600_bib13","first-page":"481","article-title":"Lung function trajectories based on annual measurements for 10 years in adults with airway obstruction","volume":"60","author":"Backman","year":"2022","journal-title":"Eur Respir J"},{"key":"2026012204332282600_bib14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1752-699X.2008.00086.x","article-title":"The Obstructive Lung Disease in Northern Sweden Chronic Obstructive Pulmonary Disease Study: design, the first year participation and mortality","volume":"2","author":"Lindberg","year":"2008","journal-title":"Clin Respir J"},{"key":"2026012204332282600_bib15","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","article-title":"Standardization of spirometry, 1994 update","volume":"152","author":"American Thoracic Society","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204332282600_bib16","doi-asserted-by":"crossref","DOI":"10.3402\/ecrj.v2.26375","article-title":"Reference values for spirometry\u2014report from the Obstructive Lung Disease in Northern Sweden studies","volume":"2","author":"Backman","year":"2015","journal-title":"Eur Clin Respir J"},{"key":"2026012204332282600_bib17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/0962280212445839","article-title":"Joint latent class models for longitudinal and time-to-event data: a review","volume":"23","author":"Proust-Lima","year":"2014","journal-title":"Stat Methods Med Res"},{"key":"2026012204332282600_bib18","doi-asserted-by":"crossref","first-page":"e0151856","DOI":"10.1371\/journal.pone.0151856","article-title":"Is COPD a progressive disease? A long term bode cohort observation","volume":"11","author":"de-Torres","year":"2016","journal-title":"PLoS ONE"},{"key":"2026012204332282600_bib19","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S2213-2600(18)30529-0","article-title":"Lung function trajectories in health and disease","volume":"7","author":"Agusti","year":"2019","journal-title":"Lancet Respir Med"},{"key":"2026012204332282600_bib20","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1164\/rccm.201707-1405OC","article-title":"Longitudinal modeling of lung function trajectories in smokers with and without chronic obstructive pulmonary disease","volume":"198","author":"Ross","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204332282600_bib21","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3109\/15412555.2015.1043423","article-title":"Individual FEV1 trajectories can be identified from a COPD cohort","volume":"13","author":"Koskela","year":"2016","journal-title":"COPD"},{"key":"2026012204332282600_bib22","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1164\/rccm.201105-0831OC","article-title":"The progression of chronic obstructive pulmonary disease is heterogeneous: the experience of the BODE cohort","volume":"184","author":"Casanova","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204332282600_bib23","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1164\/rccm.202003-0532OC","article-title":"Importance of early COPD in young adults for development of clinical COPD: findings from the Copenhagen General Population Study","volume":"203","author":"\u00c7olak","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204332282600_bib24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S2213-2600(22)00364-2","article-title":"Lifetime spirometry patterns of obstruction and restriction, and their risk factors and outcomes: a prospective cohort study","volume":"11","author":"Dharmage","year":"2023","journal-title":"Lancet Respir Med"},{"key":"2026012204332282600_bib25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/thx.2008.112136","article-title":"Early life origins of chronic obstructive pulmonary disease","volume":"65","author":"Svanes","year":"2010","journal-title":"Thorax"},{"key":"2026012204332282600_bib26","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S2213-2600(13)70118-8","article-title":"Early lung development: lifelong effect on respiratory health and disease","volume":"1","author":"Stocks","year":"2013","journal-title":"Lancet Respir Med"},{"key":"2026012204332282600_bib27","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S2213-2600(21)00508-7","article-title":"Association between very to moderate preterm births, lung function deficits, and COPD at age 53 years: analysis of a prospective cohort study","volume":"10","author":"Bui","year":"2022","journal-title":"Lancet Respir Med"},{"key":"2026012204332282600_bib28","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/thoraxjnl-2013-204778","article-title":"Lessons from ECLIPSE: a review of COPD biomarkers","volume":"69","author":"Faner","year":"2014","journal-title":"Thorax"},{"key":"2026012204332282600_bib29","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1165\/rcmb.2021-0403OC","article-title":"Chronic obstructive pulmonary disease is associated with epigenome-wide differential methylation in BAL lung cells","volume":"66","author":"Eriksson Str\u00f6m","year":"2022","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204332282600_bib30","doi-asserted-by":"crossref","first-page":"2101954","DOI":"10.1183\/13993003.01954-2021","article-title":"A polygenic risk score and age of diagnosis of COPD","volume":"60","author":"Zhang","year":"2022","journal-title":"Eur Respir J"},{"key":"2026012204332282600_bib31","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1164\/rccm.202203-0444OC","article-title":"Plasticity of individual lung function states from childhood to adulthood","volume":"207","author":"Wang","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204332282600_bib32","doi-asserted-by":"crossref","first-page":"00301-02022","DOI":"10.1183\/23120541.00301-2022","article-title":"Biomarker-based clustering of patients with chronic obstructive pulmonary disease","volume":"9","author":"Vanfleteren","year":"2023","journal-title":"ERJ Open Res"},{"key":"2026012204332282600_bib33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1378\/chest.10-2761","article-title":"Family history is a risk factor for COPD","volume":"140","author":"Hersh","year":"2011","journal-title":"Chest"},{"key":"2026012204332282600_bib34","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1186\/1471-2458-11-911","article-title":"Distal and proximal family predictors of adolescents\u2019 smoking initiation and development: a longitudinal latent curve model analysis","volume":"11","author":"Tjora","year":"2011","journal-title":"BMC Public Health"},{"key":"2026012204332282600_bib35","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1183\/09031936.02.00532002","article-title":"Prognostic value of weight change in chronic obstructive pulmonary disease: results from the Copenhagen City Heart Study","volume":"20","author":"Prescott","year":"2002","journal-title":"Eur Respir J"},{"key":"2026012204332282600_bib36","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1164\/ajrccm.160.6.9902115","article-title":"Prognostic value of nutritional status in chronic obstructive pulmonary disease","volume":"160","author":"Landbo","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204332282600_bib37","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1136\/thx.2007.086827","article-title":"Obesity and the lung: 5. Obesity and COPD","volume":"63","author":"Franssen","year":"2008","journal-title":"Thorax"},{"key":"2026012204332282600_bib38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.chest.2016.08.1432","article-title":"Obesity is associated with increased morbidity in moderate to severe COPD","volume":"151","author":"Lambert","year":"2017","journal-title":"Chest"},{"key":"2026012204332282600_bib39","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/resp.14325","article-title":"Treatable traits in the NOVELTY study","volume":"27","author":"Agust\u00ed","year":"2022","journal-title":"Respirology"},{"key":"2026012204332282600_bib40","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1183\/13993003.01359-2015","article-title":"Treatable traits: toward precision medicine of chronic airway diseases","volume":"47","author":"Agusti","year":"2016","journal-title":"Eur Respir J"},{"key":"2026012204332282600_bib41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12931-021-01656-5","article-title":"Gender modifies the effect of body mass index on lung function decline in mild-to-moderate COPD patients: a pooled analysis","volume":"22","author":"Chen","year":"2021","journal-title":"Respir Res"},{"key":"2026012204332282600_bib42","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/15412550601168358","article-title":"Decline in FEV1 in relation to incident chronic obstructive pulmonary disease in a cohort with respiratory symptoms","volume":"4","author":"Lindberg","year":"2007","journal-title":"COPD"},{"key":"2026012204332282600_bib43","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1183\/09031936.00055514","article-title":"Interaction between asthma and smoking increases the risk of adult airway obstruction","volume":"45","author":"Aanerud","year":"2015","journal-title":"Eur Respir J"},{"key":"2026012204332282600_bib44","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1164\/rccm.200508-1344OC","article-title":"Lung function decline and outcomes in an adult population","volume":"173","author":"Mannino","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204332282600_bib45","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1164\/rccm.200712-1869OC","article-title":"Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study","volume":"178","author":"Celli","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204332282600_bib46","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1056\/NEJMoa0805800","article-title":"A 4-year trial of tiotropium in chronic obstructive pulmonary disease","volume":"359","author":"Tashkin","year":"2008","journal-title":"N Engl J Med"},{"key":"2026012204332282600_bib47","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S2213-2600(17)30434-4","article-title":"Lung function in early adulthood and health in later life: a transgenerational cohort analysis","volume":"5","author":"Agust\u00ed","year":"2017","journal-title":"Lancet Respir Med"},{"key":"2026012204332282600_bib48","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1164\/rccm.202005-1854OC","article-title":"Pharmacotherapy and lung function decline in patients with chronic obstructive pulmonary disease: a systematic review","volume":"203","author":"Celli","year":"2021","journal-title":"Am J Respir Crit Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/208\/10\/1063\/66425846\/ajrccm_208_10_1063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/208\/10\/1063\/66425846\/ajrccm_208_10_1063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:33:34Z","timestamp":1769074414000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/208\/10\/1063\/8426687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":48,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,11,15]]},"published-print":{"date-parts":[[2023,11,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202211-2166oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11]]},"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2022-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}