{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:42:02Z","timestamp":1793875322335,"version":"4.6.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["K23GM128005"],"award-info":[{"award-number":["K23GM128005"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes, Digestive, and Kidney Diseases","doi-asserted-by":"crossref","award":["R01 DK130929"],"award-info":[{"award-number":["R01 DK130929"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24HL127101"],"award-info":[{"award-number":["K24HL127101"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["K23GM128005"],"award-info":[{"award-number":["K23GM128005"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of Diabetes, Digestive, and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK130929"],"award-info":[{"award-number":["R01 DK130929"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24HL127101"],"award-info":[{"award-number":["K24HL127101"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Kidney injury is common and associated with worse outcomes in patients with septic shock. Mitochondrial resuscitation with thiamine (vitamin B1) may attenuate septic kidney injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess whether thiamine supplementation attenuates kidney injury in septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The TRPSS (Thiamine for Renal Protection in Septic Shock) trial was a multicenter, randomized, placebo-controlled trial of thiamine versus placebo in septic shock. The primary outcome was change in serum creatinine between enrollment and 72\u2009hours after enrollment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Eighty-eight patients were enrolled (42 patients received the intervention, and 46 received placebo). There was no significant between-groups difference in creatinine at 72\u2009hours (mean difference, \u22120.57\u2009mg\/dl; 95% confidence interval, \u22121.18, 0.04; P\u2009=\u20090.07). There was no difference in receipt of kidney replacement therapy (14.3% vs. 21.7%, P\u2009=\u20090.34), acute kidney injury (as defined by stage 3 of the Kidney Disease: Improving Global Outcomes acute kidney injury scale; 54.7% vs. 73.9%, P\u2009=\u20090.07), or mortality (35.7% vs. 54.3%, P\u2009=\u20090.14) between the thiamine and placebo groups. Patients who received thiamine had more ICU-free days (median [interquartile range]: 22.5 [0.0\u201325.0] vs. 0.0 [0.0\u201323.0], P\u2009&amp;lt;\u20090.01). In the thiamine-deficient cohort (27.4% of patients), there was no difference in rates of kidney failure (57.1% thiamine vs. 81.5% placebo) or in-hospital mortality (28.6% vs. 68.8%) between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the TRPSS trial, there was no statistically significant difference in the primary outcome of change in creatinine over time. Patients who received thiamine had more ICU-free days, but there was no difference in other secondary outcomes.<\/jats:p>\n                    <jats:p>Clinical trial registered with www.clinicaltrials.gov (NCT 03550794).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202301-0034oc","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T17:18:15Z","timestamp":1687799895000},"page":"570-578","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":29,"title":["Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-controlled, Clinical Trial"],"prefix":"10.1093","volume":"208","author":[{"given":"Ari","family":"Moskowitz","sequence":"first","affiliation":[{"name":"Division of Critical Care Medicine, Montefiore Medical Center, The Bronx, New York"},{"name":"Bronx Center for Critical Care Outcomes and Resuscitation Research, The Bronx, New York"},{"name":"Center for Resuscitation Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Berg","sequence":"additional","affiliation":[{"name":"Center for Resuscitation Science"},{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne V.","family":"Grossestreuer","sequence":"additional","affiliation":[{"name":"Center for Resuscitation Science"},{"name":"Department of Emergency Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshman","family":"Balaji","sequence":"additional","affiliation":[{"name":"Center for Resuscitation Science"},{"name":"Department of Emergency Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Resuscitation Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Cocchi","sequence":"additional","affiliation":[{"name":"Center for Resuscitation Science"},{"name":"Department of Emergency Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Chase","sequence":"additional","affiliation":[{"name":"Center for Resuscitation Science"},{"name":"Department of Emergency Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Ng","family":"Gong","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Montefiore Medical Center, The Bronx, New York"},{"name":"Bronx Center for Critical Care Outcomes and Resuscitation Research, The Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Long Island Jewish Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, New Hyde Park, New York; 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