{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T01:48:06Z","timestamp":1769132886335,"version":"3.49.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":997,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL153248"],"award-info":[{"award-number":["R01HL153248"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL149861"],"award-info":[{"award-number":["R01HL149861"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL147148"],"award-info":[{"award-number":["R01HL147148"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL153248"],"award-info":[{"award-number":["R01HL153248"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL149861"],"award-info":[{"award-number":["R01HL149861"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL147148"],"award-info":[{"award-number":["R01HL147148"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5,15]]},"DOI":"10.1164\/rccm.202303-0468ed","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T14:05:51Z","timestamp":1679666751000},"page":"1261-1262","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":0,"title":["Who Modifies the Modifiers: A High-Resolution View of the Genetic Modifiers of Cystic Fibrosis"],"prefix":"10.1093","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2087-8397","authenticated-orcid":false,"given":"Sean","family":"Kalra","sequence":"first","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-1657","authenticated-orcid":false,"given":"Michael H.","family":"Cho","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"2026012204432834100_bib1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1126\/science.2475911","article-title":"Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA","volume":"245","author":"Riordan","year":"1989","journal-title":"Science"},{"key":"2026012204432834100_bib2","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1126\/science.2570460","article-title":"Identification of the cystic fibrosis gene: genetic analysis","volume":"245","author":"Kerem","year":"1989","journal-title":"Science"},{"key":"2026012204432834100_bib3","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1164\/rccm.200608-1164OC","article-title":"Heritability of lung disease severity in cystic fibrosis","volume":"175","author":"Vanscoy","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204432834100_bib4","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.3390\/cells10102793","article-title":"Therapeutic approaches for patients with cystic fibrosis not eligible for current CFTR modulators","volume":"10","author":"Fajac","year":"2021","journal-title":"Cells"},{"key":"2026012204432834100_bib5","doi-asserted-by":"crossref","first-page":"103660","DOI":"10.1016\/j.ebiom.2021.103660","article-title":"Perspectives on the translation of in-vitro studies to precision medicine in cystic fibrosis","volume":"73","author":"Dumas","year":"2021","journal-title":"EBioMedicine"},{"key":"2026012204432834100_bib6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the missing heritability of complex diseases","volume":"461","author":"Manolio","year":"2009","journal-title":"Nature"},{"key":"2026012204432834100_bib7","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1164\/rccm.202209-1653OC","article-title":"Genetic modifiers of cystic fibrosis lung disease severity: whole genome analysis of 7,840 patients","volume":"207","author":"Zhou","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204432834100_bib8","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/ppul.21456","article-title":"A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis genetic modifier studies","volume":"46","author":"Taylor","year":"2011","journal-title":"Pediatr Pulmonol"},{"key":"2026012204432834100_bib9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1164\/rccm.200410-1335OC","article-title":"Disease-specific reference equations for lung function in patients with cystic fibrosis","volume":"172","author":"Kulich","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204432834100_bib10","doi-asserted-by":"crossref","first-page":"8382","DOI":"10.1038\/ncomms9382","article-title":"Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis","volume":"6","author":"Corvol","year":"2015","journal-title":"Nat Commun"},{"key":"2026012204432834100_bib11","doi-asserted-by":"crossref","first-page":"e0239189","DOI":"10.1371\/journal.pone.0239189","article-title":"Mining GWAS and eQTL data for CF lung disease modifiers by gene expression imputation","volume":"15","author":"Dang","year":"2020","journal-title":"PLoS One"},{"key":"2026012204432834100_bib12","doi-asserted-by":"crossref","first-page":"13588","DOI":"10.1093\/nar\/gku1146","article-title":"Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells","volume":"42","author":"Fossum","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2026012204432834100_bib13","doi-asserted-by":"crossref","first-page":"E54","DOI":"10.1073\/pnas.1308768111","article-title":"Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme","volume":"111","author":"Kang","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026012204432834100_bib14","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1056\/NEJMoa1513737","article-title":"Patterns of growth and decline in lung function in persistent childhood asthma","volume":"374","author":"McGeachie","year":"2016","journal-title":"N Engl J Med"},{"key":"2026012204432834100_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1152\/jappl.1974.37.1.67","article-title":"Variability of maximum expiratory flow-volume curves","volume":"37","author":"Green","year":"1974","journal-title":"J Appl Physiol"},{"key":"2026012204432834100_bib16","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1001\/jama.2020.6918","article-title":"Association of dysanapsis with chronic obstructive pulmonary disease among older adults","volume":"323","author":"Smith","year":"2020","journal-title":"JAMA"},{"key":"2026012204432834100_bib17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1086\/381001","article-title":"Variation in a repeat sequence determines whether a common variant of the cystic fibrosis transmembrane conductance regulator gene is pathogenic or benign","volume":"74","author":"Groman","year":"2004","journal-title":"Am J Hum Genet"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/207\/10\/1261\/66435858\/ajrccm_207_10_1261.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/207\/10\/1261\/66435858\/ajrccm_207_10_1261.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:43:45Z","timestamp":1769075025000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/207\/10\/1261\/8427990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":17,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5,15]]},"published-print":{"date-parts":[[2023,5,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202303-0468ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2023-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}