{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:29:49Z","timestamp":1785886189614,"version":"3.56.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":721,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Optimum Patient Care Global"},{"name":"AstraZeneca Ltd"},{"name":"Optimum Patient Care Global"},{"name":"AstraZeneca Ltd"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Previous studies investigating the impact of comorbidities on the effectiveness of biologic agents have been relatively small and of short duration and have not compared classes of biologic agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the association between type 2\u2013related comorbidities and biologic agent effectiveness in adults with severe asthma (SA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cohort study used International Severe Asthma Registry data from 21 countries (2017\u20132022) to quantify changes in four outcomes before and after biologic therapy\u2014annual asthma exacerbation rate, FEV1% predicted, asthma control, and long-term oral corticosteroid daily dose\u2014in patients with or without allergic rhinitis, chronic rhinosinusitis (CRS) with or without nasal polyps (NPs), NPs, or eczema\/atopic dermatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Of 1,765 patients, 1,257, 421, and 87 initiated anti\u2013IL-5\/5 receptor, anti-IgE, and anti\u2013IL-4\/13 therapies, respectively. In general, pre- versus post\u2013biologic therapy improvements were noted in all four asthma outcomes assessed, irrespective of comorbidity status. However, patients with comorbid CRS with or without NPs experienced 23% fewer exacerbations per year (95% CI, 10\u201335%; P\u2009&amp;lt;\u20090.001) and had 59% higher odds of better post\u2013biologic therapy asthma control (95% CI, 26\u2013102%; P\u2009&amp;lt;\u20090.001) than those without CRS with or without NPs. Similar estimates were noted for those with comorbid NPs: 22% fewer exacerbations and 56% higher odds of better post\u2013biologic therapy control. Patients with SA and CRS with or without NPs had an additional FEV1% predicted improvement of 3.2% (95% CI, 1.0\u20135.3; P\u2009=\u20090.004), a trend that was also noted in those with comorbid NPs. The presence of allergic rhinitis or atopic dermatitis was not associated with post\u2013biologic therapy effect for any outcome assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings highlight the importance of systematic comorbidity evaluation. The presence of CRS with or without NPs or NPs alone may be considered a predictor of the effectiveness of biologic agents in patients with SA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202305-0808oc","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T14:32:46Z","timestamp":1701181966000},"page":"262-272","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":59,"title":["Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma"],"prefix":"10.1093","volume":"209","author":[{"given":"Michael E.","family":"Wechsler","sequence":"first","affiliation":[{"name":"Cohen Family Asthma Institute and Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislaine","family":"Scelo","sequence":"additional","affiliation":[{"name":"Observational and Pragmatic Research Institute, Singapore"},{"name":"Optimum Patient Care Global, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9sir\u00e9e E. S.","family":"Larenas-Linnemann","sequence":"additional","affiliation":[{"name":"Centro de Excelencia en Asma y Alergia, Hospital M\u00e9dica Sur, Ciudad de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0004-8955","authenticated-orcid":false,"given":"Carlos A.","family":"Torres-Duque","sequence":"additional","affiliation":[{"name":"CINEUMO\/Centro Internacional de Investigaci\u00f3n en Neumolog\u00eda, Respiratory Research Center, Fundaci\u00f3n Neumol\u00f3gica Colombiana, Bogot\u00e1, Colombia"},{"name":"Universidad de La Sabana, Chia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Maspero","sequence":"additional","affiliation":[{"name":"Clinical Research for Allergy and Respiratory Medicine, CIDEA Foundation, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung N.","family":"Tran","sequence":"additional","affiliation":[{"name":"BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth B.","family":"Murray","sequence":"additional","affiliation":[{"name":"Optimum Patient Care Global, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Martin","sequence":"additional","affiliation":[{"name":"BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Maryland"},{"name":"University of Leicester, Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Menzies-Gow","sequence":"additional","affiliation":[{"name":"AstraZeneca, Cambridge, United Kingdom"},{"name":"Royal Brompton & Harefield Hospitals, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hew","sequence":"additional","affiliation":[{"name":"Allergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, Victoria, Australia"},{"name":"Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, Concord Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Australian Severe Asthma Network, Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South Wales, Australia"},{"name":"Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Christoff","sequence":"additional","affiliation":[{"name":"Medical University, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todor A.","family":"Popov","sequence":"additional","affiliation":[{"name":"University Hospital Sv. 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