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Current treatments, such as continuous positive airway pressure (CPAP), have shown limited cognitive, metabolic, and cardiovascular beneficial outcomes despite adherence. Thus, adjunct therapies aiming to reduce OSA burden, such as senolytics, could improve OSA outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess if targeting senescence in addition to partial normoxia mimicking \u201cgood\u201d CPAP adherence can improve physiological outcomes in mice exposed to chronic intermittent hypoxia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared the effects of 6\u2009weeks of therapy with either partial normoxic recovery alone or combined with the senolytic navitoclax after 16\u2009weeks of intermittent hypoxia exposures, a hallmark of OSA, on multiphenotypic cardiometabolic and neurocognitive parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Our findings indicate that only when combined with navitoclax, partial normoxic recovery significantly improved sleepiness (sleep in the dark phase: 34%\u2009\u00b1\u20094% vs. 26%\u2009\u00b1\u20093%; P\u2009&amp;lt;\u20090.01), cognition (preference score: 51%\u2009\u00b1\u200919% vs. 70%\u2009\u00b1\u200911%; P\u2009=\u20090.048), coronary artery function (response to acetylcholine [vasodilation]: 56%\u2009\u00b1\u200913% vs. 72%\u2009\u00b1\u200910%; P\u2009&amp;lt;\u20090.001), glucose, and lipid metabolism and reduced intestinal permeability and senescence in multiple organs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that the reversibility of end-organ morbidities induced by OSA is not only contingent on restoration of normal oxygenation patterns but can be further enhanced by targeting other OSA-mediated detrimental cellular processes, such as accelerated senescence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202306-1101oc","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T12:50:10Z","timestamp":1702990210000},"page":"1001-1012","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":30,"title":["Senolytic-facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea"],"prefix":"10.1093","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7073-741X","authenticated-orcid":false,"given":"Mohammad","family":"Badran","sequence":"first","affiliation":[{"name":"Department of Child Health and Child Health Research Institute, School of Medicine, University of Missouri, Columbia, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementine","family":"Puech","sequence":"additional","affiliation":[{"name":"Department of Child Health and Child Health Research Institute, School of Medicine, University of Missouri, Columbia, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelnaby","family":"Khalyfa","sequence":"additional","affiliation":[{"name":"Department of Child Health and Child Health Research Institute, School of Medicine, University of Missouri, Columbia, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9262-7828","authenticated-orcid":false,"given":"Rene","family":"Cortese","sequence":"additional","affiliation":[{"name":"Department of Child Health and Child Health Research Institute, School of Medicine, University of Missouri, Columbia, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Cataldo","sequence":"additional","affiliation":[{"name":"Department of Child Health and Child Health Research Institute, School of Medicine, University of Missouri, Columbia, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuanhong","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Child Health and Child Health Research Institute, School of Medicine, University of Missouri, Columbia, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8195-6036","authenticated-orcid":false,"given":"David","family":"Gozal","sequence":"additional","affiliation":[{"name":"Department of Child Health and Child Health Research Institute, School of Medicine, University of Missouri, Columbia, Missouri; and"},{"name":"Joan C. 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