{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:00:13Z","timestamp":1793271613416,"version":"4.5.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Richard H. Scarborough Bronchiectasis Research Fund"},{"DOI":"10.13039\/100017769","name":"Anna-Maria and Stephen Kellen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017769","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bronchiectasis and NTM Industry Advisory Committee"},{"name":"Richard H. Scarborough Bronchiectasis Research Fund"},{"DOI":"10.13039\/100017769","name":"Anna-Maria and Stephen Kellen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017769","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bronchiectasis and NTM Industry Advisory Committee"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Nontuberculous mycobacteria (NTM) are prevalent among patients with bronchiectasis. However, the long-term natural history of patients with NTM and bronchiectasis is not well described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the impact of NTM on 5-year clinical outcomes and mortality in patients with bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients in the Bronchiectasis and NTM Research Registry with \u2a7e5\u2009years of follow-up were eligible. Data were collected for all-cause mortality, lung function, exacerbations, hospitalizations, and disease severity. Outcomes were compared between patients with and without NTM at baseline. Mortality was assessed using Cox proportional hazards models and the log-rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>In total, 2,634 patients were included: 1,549 (58.8%) with and 1,085 (41.2%) without NTM at baseline. All-cause mortality (95% confidence interval) at Year 5 was 12.1% (10.5%, 13.7%) overall, 12.6% (10.5%, 14.8%) in patients with NTM, and 11.5% (9.0%, 13.9%) in patients without NTM. Independent predictors of 5-year mortality were baseline FEV1 percent predicted, age, hospitalization within 2\u2009years before baseline, body mass index, and sex (all P\u2009&amp;lt;\u20090.01). The probabilities of acquiring NTM or Pseudomonas aeruginosa were approximately 4% and 3% per year, respectively. Spirometry, exacerbations, and hospitalizations were similar, regardless of NTM status, except that annual exacerbations were lower in patients with NTM (P\u2009&amp;lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Outcomes, including exacerbations, hospitalizations, rate of loss of lung function, and mortality rate, were similar across 5\u2009years in patients with bronchiectasis with or without NTM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202307-1165oc","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T10:12:06Z","timestamp":1714126326000},"page":"108-118","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":47,"title":["Five-Year Outcomes among U.S. Bronchiectasis and NTM Research Registry Patients"],"prefix":"10.1093","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5243-5394","authenticated-orcid":false,"given":"Timothy R.","family":"Aksamit","sequence":"first","affiliation":[{"name":"COPD Foundation, Washington, District of Columbia"},{"name":"Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6442-0683","authenticated-orcid":false,"given":"Nicholas","family":"Locantore","sequence":"additional","affiliation":[{"name":"COPD Foundation, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-8101","authenticated-orcid":false,"given":"Doreen","family":"Addrizzo-Harris","sequence":"additional","affiliation":[{"name":"School of Medicine, New York University, New York, New 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