{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:56:26Z","timestamp":1793386586807,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009243","name":"Direction G\u00e9n\u00e9rale de l\u2019Offre de Soins","doi-asserted-by":"publisher","award":["AOM 12116"],"award-info":[{"award-number":["AOM 12116"]}],"id":[{"id":"10.13039\/501100009243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002738","name":"Assistance Publique\u2013H\u00f4pitaux de Paris","doi-asserted-by":"publisher","award":["Appel \u00e0 Projet Interne 2017"],"award-info":[{"award-number":["Appel \u00e0 Projet Interne 2017"]}],"id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Direction G\u00e9n\u00e9rale de l\u2019Offre de Soins","award":["AOM 12116"],"award-info":[{"award-number":["AOM 12116"]}]},{"DOI":"10.13039\/501100002738","name":"Assistance Publique\u2013H\u00f4pitaux de Paris","doi-asserted-by":"publisher","award":["Appel \u00e0 Projet Interne 2017"],"award-info":[{"award-number":["Appel \u00e0 Projet Interne 2017"]}],"id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Airway occlusion pressure at 100\u2009ms (P0.1) reflects central respiratory drive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to assess factors associated with P0.1 and whether an abnormally low or high P0.1 value is associated with higher mortality and longer duration of mechanical ventilation (MV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a secondary analysis of a prospective cohort study conducted in 10 ICUs in France to evaluate dyspnea in communicative MV patients. In patients intubated for more than 24\u2009hours, P0.1 was measured with dyspnea as soon as patients could communicate and the next day.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Among 260 patients assessed after a median time of ventilation of 4\u2009days, P0.1 was 1.9 (1\u20133.5) cm H2O at enrollment, 24% had P0.1 values &amp;gt;3.5\u2009cm H2O, 37% had P0.1 values between 1.5 and 3.5\u2009cm H2O, and 39% had P0.1 values &amp;lt;1.5\u2009cm H2O. In multivariable linear regression, independent factors associated with P0.1 were the presence of dyspnea (P\u2009=\u20090.037), respiratory rate (P\u2009&amp;lt;\u20090.001), and PaO2 (P\u2009=\u20090.008). Ninety-day mortality was 33% in patients with P0.1\u2009&amp;gt;\u20093.5\u2009cm H2O versus 19% in those with P0.1 between 1.5 and 3.5\u2009cm H2O and 17% in those with P0.1\u2009&amp;lt;\u20091.5\u2009cm H2O (P\u2009=\u20090.046). After adjustment for the main risk factors, P0.1 was associated with 90-day mortality (hazard ratio per 1\u2009cm H2O, 1.19 [95% confidence interval, 1.04\u20131.37]; P\u2009=\u20090.011). P0.1 was also independently associated with a longer duration of MV (hazard ratio per 1\u2009cm H2O, 1.10 [95% confidence interval, 1.02\u20131.19]; P\u2009=\u20090.016).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients receiving invasive MV, abnormally high P0.1 values may suggest dyspnea and are associated with higher mortality and prolonged duration of MV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202308-1358oc","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T09:23:48Z","timestamp":1707211428000},"page":"201-210","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":53,"title":["High Airway Occlusion Pressure Is Associated with Dyspnea and Increased Mortality in Critically Ill Mechanically Ventilated Patients"],"prefix":"10.1093","volume":"210","author":[{"given":"Julien","family":"Le Marec","sequence":"first","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, 26930, Groupe Hospitalier Universitaire Assistance Publique\u2013H\u00f4pitaux de Paris\u2013Sorbonne Universit\u00e9, Site Piti\u00e9-Salp\u00eatri\u00e8re, Service de M\u00e9decine Intensive et R\u00e9animation (D\u00e9partement R3S), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hajage","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, D\u00e9partement de Sant\u00e9 Publique, Centre de Pharmaco\u00e9pid\u00e9miologie (Cephepi), Unit\u00e9 de Recherche Clinique PSL-CFX, CIC-1901, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxens","family":"Decav\u00e8le","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, 26930, Groupe Hospitalier Universitaire Assistance Publique\u2013H\u00f4pitaux de Paris\u2013Sorbonne Universit\u00e9, Site Piti\u00e9-Salp\u00eatri\u00e8re, Service de M\u00e9decine Intensive et R\u00e9animation (D\u00e9partement R3S), Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, Paris, France"},{"name":"Sorbonne Universit\u00e9, GRC 30, Reanimation et Soins Intensifs du Patient en Insuffisance Respiratoire Aigu\u00eb, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, GRC 30, Reanimation et Soins Intensifs du Patient en Insuffisance Respiratoire Aigu\u00eb, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"},{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Institut de Cardiologie, Assistance Publique\u2013H\u00f4pitaux de Paris Sorbonne Universit\u00e9 H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, Research Unit on Cardiovascular Diseases, Metabolism and Nutrition, ICAN, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaura","family":"Laurent","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, D\u00e9partement de Sant\u00e9 Publique, Centre de Pharmaco\u00e9pid\u00e9miologie (Cephepi), Unit\u00e9 de Recherche Clinique PSL-CFX, CIC-1901, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Damien","family":"Ricard","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Louis Mourier, DMU ESPRIT, Service de M\u00e9decine Intensive R\u00e9animation, Colombes, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, UMR1137 IAME, INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Jaber","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Unit, Regional University Hospital of Montpellier, St-Eloi Hospital, University of Montpellier, PhyMedExp, INSERM U1046, CNRS UMR 9214, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-1508","authenticated-orcid":false,"given":"Elie","family":"Azoulay","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive et R\u00e9animation, H\u00f4pital Saint-Louis, Assistance Publique\u2013H\u00f4pitaux de Paris, and Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Fartoukh","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, Sorbonne Universit\u00e9, Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital Tenon, Paris, France"},{"name":"Sorbonne Universit\u00e9, UFR M\u00e9decine, Paris, France"},{"name":"Groupe de Recherche Clinique CARMAS, Universit\u00e9 Paris Est Cr\u00e9teil, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Hraiech","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Marseille, H\u00f4pital Nord, M\u00e9decine Intensive R\u00e9animation, Marseille, France"},{"name":"Centre d\u2019Etudes et de Recherches sur les Services de Sant\u00e9 et Qualit\u00e9 de Vie EA 3279, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Mercat","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale et M\u00e9decine Hyperbare, Centre Hospitalier R\u00e9gional Universitaire, Angers, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2868-9279","authenticated-orcid":false,"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et 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