{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:47:28Z","timestamp":1787856448815,"version":"build-2784847793"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100008207","name":"AstraZeneca Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008207","name":"AstraZeneca Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008207","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12,15]]},"DOI":"10.1164\/rccm.202308-1413le","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T14:58:12Z","timestamp":1697122692000},"page":"1330-1335","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":36,"title":["Benralizumab Normalizes Sputum Eosinophilia in Severe Asthma Uncontrolled by Anti\u2013IL-5 Antibodies: A Single-Blind, Placebo-controlled Clinical Trial"],"prefix":"10.1093","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7924-7211","authenticated-orcid":false,"given":"Manali","family":"Mukherjee","sequence":"first","affiliation":[{"name":"Division of Respirology, Department of Medicine, McMaster University & St Joseph\u2019s Healthcare Hamilton, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chynna","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Respirology, Department of Medicine, McMaster University & St Joseph\u2019s Healthcare Hamilton, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Venegas-Garrido","sequence":"additional","affiliation":[{"name":"Division of Respirology, Department of Medicine, McMaster University & St Joseph\u2019s Healthcare Hamilton, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Respirology, Department of Medicine, McMaster University & St Joseph\u2019s Healthcare Hamilton, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Division of Respirology, Department of Medicine, McMaster University & St Joseph\u2019s Healthcare Hamilton, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Ju","sequence":"additional","affiliation":[{"name":"Division of Respirology, Department of Medicine, McMaster University & St Joseph\u2019s Healthcare Hamilton, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"O\u2019Byrne","sequence":"additional","affiliation":[{"name":"Division of Respirology, Department of Medicine, McMaster University & St Joseph\u2019s Healthcare Hamilton, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Svenningsen","sequence":"additional","affiliation":[{"name":"Division of Respirology, Department of Medicine, McMaster University & St Joseph\u2019s Healthcare Hamilton, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roma","family":"Sehmi","sequence":"additional","affiliation":[{"name":"Division of Respirology, Department of Medicine, McMaster University & St Joseph\u2019s Healthcare Hamilton, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-9492","authenticated-orcid":false,"given":"Parameswaran","family":"Nair","sequence":"additional","affiliation":[{"name":"Division of Respirology, Department of Medicine, McMaster University & St Joseph\u2019s Healthcare Hamilton, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"2026012204394745200_bib1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1164\/rccm.201810-1944CI","article-title":"Role of biologics in asthma","volume":"199","author":"McGregor","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204394745200_bib2","doi-asserted-by":"crossref","first-page":"2000117","DOI":"10.1183\/13993003.00117-2020","article-title":"Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena","volume":"56","author":"Mukherjee","year":"2020","journal-title":"Eur Respir J"},{"key":"2026012204394745200_bib3","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.jaci.2018.01.008","article-title":"Benralizumab attenuates airway eosinophilia in prednisone-dependent asthma","volume":"141","author":"Sehmi","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"2026012204394745200_bib4","first-page":"3994","article-title":"Benralizumab attenuates blood and airway eosinophilia in severe asthmatics with inadequate response to anti-IL-5 neutralizing antibodies","volume":"60","author":"Mukherjee","year":"2022","journal-title":"Eur Respir J"},{"key":"2026012204394745200_bib5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1183\/09031936.00202013","article-title":"International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma","volume":"43","author":"Chung","year":"2014","journal-title":"Eur Respir J"},{"key":"2026012204394745200_bib6","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1183\/09031936.96.09061174","article-title":"Measurement of inflammatory indices in induced sputum: effects of selection of sputum to minimize salivary contamination","volume":"9","author":"Pizzichini","year":"1996","journal-title":"Eur Respir J"},{"key":"2026012204394745200_bib7","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1164\/rccm.201909-1722OC","article-title":"The role of the TL1A\/DR3 axis in the activation of group 2 innate lymphoid cells in subjects with eosinophilic asthma","volume":"202","author":"Machida","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204394745200_bib8","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1172\/JCI95693","article-title":"Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction","volume":"128","author":"Dunican","year":"2018","journal-title":"J Clin Invest"},{"key":"2026012204394745200_bib9","doi-asserted-by":"crossref","first-page":"e149945","DOI":"10.1172\/jci.insight.149945","article-title":"Machine learning implicates the IL-18 signaling axis in severe asthma","volume":"6","author":"Camiolo","year":"2021","journal-title":"JCI Insight"},{"key":"2026012204394745200_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.anai.2013.09.004","article-title":"Interleukin-18 expression, CD8(+) T cells, and eosinophils in lungs of nonsmokers with fatal asthma","volume":"112","author":"Oda","year":"2014","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/208\/12\/1330\/66425142\/ajrccm_208_12_1330.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/208\/12\/1330\/66425142\/ajrccm_208_12_1330.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:39:59Z","timestamp":1769074799000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/208\/12\/1330\/8426838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12,15]]},"published-print":{"date-parts":[[2023,12,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202308-1413le","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}