{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:57:56Z","timestamp":1793447876078,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL 164420"],"award-info":[{"award-number":["R01 HL 164420"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL 1446689"],"award-info":[{"award-number":["R01 HL 1446689"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Parker B. 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Francis Fellowship Program"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Hemodynamically significant patent ductus arteriosus (hsPDA) in premature infants has been associated with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). However, these associations remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the associations between hsPDA duration and clinical outcomes, PH, and phenotypic differences on lung magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, we identified all infants with BPD at &amp;lt;32\u2009weeks\u2019 gestation who also underwent research lung MRI at &amp;lt;48\u2009weeks\u2019 postmenstrual age (PMA) from 2014 to 2022. Clinical echocardiograms were reviewed for hsPDA and categorized as no hsPDA, hsPDA 1\u201360\u2009days, and hsPDA &amp;gt;60\u2009days. Outcome variables included BPD severity, PH at 36\u2009weeks\u2019 PMA, PH after 36\u2009weeks\u2019 PMA in the absence of shunt (PH\u2013pulmonary vascular disease [PVD]), tracheostomy or death, and lung phenotype by MRI via modified Ochiai score, indexed total lung volume, and whole-lung hyperdensity. Logistic regression and ANOVA were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>In total, 133 infants born at 26.2\u2009\u00b1\u20091.9\u2009weeks, weighing 776\u2009\u00b1\u2009276\u2009g, were reviewed (47 with no hsPDA, 44 with hsPDA 1\u201360\u2009days, and 42 with hsPDA &amp;gt;60 d). hsPDA duration\u2009&amp;gt;\u200960\u2009days was associated with BPD severity (P\u2009&amp;lt;\u20090.01), PH at 36\u2009weeks\u2019 PMA (adjusted odds ratio [aOR], 9.7 [95% confidence interval (CI), 3.3\u201328.4]), PH\u2013PVD (aOR, 6.5 [95% CI, 2.3\u201318.3]), and tracheostomy or death (aOR, 3.0 [95% CI, 1.0\u20138.8]). Duration of hsPDA\u2009&amp;gt;\u200960\u2009days was associated with higher Ochiai score (P\u2009=\u20090.03) and indexed total lung volume (P\u2009=\u20090.01) but not whole-lung hyperdensity (P\u2009=\u20090.91).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In infants with moderate or severe BPD, prolonged exposure to hsPDA is associated with BPD severity, PH\u2013PVD, and increased parenchymal lung disease by MRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202310-1733oc","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T11:47:06Z","timestamp":1712144826000},"page":"318-328","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":16,"title":["Patent Ductus Arteriosus and Lung Magnetic Resonance Imaging Phenotype in Moderate and Severe Bronchopulmonary Dysplasia\u2013Pulmonary Hypertension"],"prefix":"10.1093","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1162-6012","authenticated-orcid":false,"given":"Kurt R.","family":"Bjorkman","sequence":"first","affiliation":[{"name":"The Heart Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3093-4384","authenticated-orcid":false,"given":"Kimberley G.","family":"Miles","sequence":"additional","affiliation":[{"name":"The Heart Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Bellew","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"The Heart Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Melissa","family":"Magness","sequence":"additional","affiliation":[{"name":"The Heart Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6233-161X","authenticated-orcid":false,"given":"Nara S.","family":"Higano","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, and"},{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ollberding","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Hoyos Cordon","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russel M.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"The Heart Institute"},{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Hysinger","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine"},{"name":"Center for Pulmonary Imaging Research, and"},{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Woods","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, and"},{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-1399","authenticated-orcid":false,"given":"Paul 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