{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:56:11Z","timestamp":1793217371784,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Medical Engineering Cross Research Fund of Shanghai Jiao Tong University","award":["YG2024QNA36"],"award-info":[{"award-number":["YG2024QNA36"]}]},{"name":"STI2030-Major Projects from National Key R&D Program of China","award":["2021ZD0201900"],"award-info":[{"award-number":["2021ZD0201900"]}]},{"name":"Interdisciplinary Program of Shanghai Jiao Tong University","award":["YG2023LC11"],"award-info":[{"award-number":["YG2023LC11"]}]},{"name":"Innovation Program of Shanghai Municipal Education Commission","award":["2017-01-07-00-02-E00047"],"award-info":[{"award-number":["2017-01-07-00-02-E00047"]}]},{"name":"Shanghai Municipal Commission of Science and Technology","award":["18DZ2260200"],"award-info":[{"award-number":["18DZ2260200"]}]},{"name":"multi-center clinical research project from school of medicine, Shanghai Jiao Tong University","award":["DLY201502"],"award-info":[{"award-number":["DLY201502"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341242"],"award-info":[{"award-number":["82341242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101205"],"award-info":[{"award-number":["82101205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Engineering Cross Research Fund of Shanghai Jiao Tong University","award":["YG2024QNA36"],"award-info":[{"award-number":["YG2024QNA36"]}]},{"name":"STI2030-Major Projects from National Key R&D Program of China","award":["2021ZD0201900"],"award-info":[{"award-number":["2021ZD0201900"]}]},{"name":"Interdisciplinary Program of Shanghai Jiao Tong University","award":["YG2023LC11"],"award-info":[{"award-number":["YG2023LC11"]}]},{"name":"Innovation Program of Shanghai Municipal Education Commission","award":["2017-01-07-00-02-E00047"],"award-info":[{"award-number":["2017-01-07-00-02-E00047"]}]},{"name":"Shanghai Municipal Commission of Science and Technology","award":["18DZ2260200"],"award-info":[{"award-number":["18DZ2260200"]}]},{"name":"multi-center clinical research project from school of medicine, Shanghai Jiao Tong University","award":["DLY201502"],"award-info":[{"award-number":["DLY201502"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341242"],"award-info":[{"award-number":["82341242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101205"],"award-info":[{"award-number":["82101205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) is associated with cognitive impairment. The effects of continuous positive airway pressure (CPAP) on neuroimaging biomarkers and cognitive performance among middle-aged patients with OSA and normal cognition remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the effects of CPAP therapy over 12 months on neuroimaging biomarkers and cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter, randomized clinical trial, we randomly assigned 148 participants with normal cognition and an apnea\u2013hypopnea index \u2a7e15\/h into two groups: patients receiving CPAP with best supportive care (BSC); and patients receiving BSC alone. The primary endpoint was Montreal Cognitive Assessment (MoCA) score at 6 months after enrollment. The secondary endpoints were intranetwork functional connectivity (FC) of default mode network (DMN) and cortical thickness assessed by functional and structural magnetic resonance imaging, other neuroimaging biomarkers, and neurobehavioral tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Between 2017 and 2021, 148 patients were recruited from five hospitals. Linear mixed models showed that there was no significant difference in MoCA scores at 6 months between the CPAP and BSC groups (difference, \u22120.04; 95% confidence interval [CI], \u22120.72 to 0.65; P\u2009=\u20090.91). However, there were significant differences in the FC of DMN (difference, \u221213.73; 95% CI, \u221223.40 to \u22124.06; P\u2009=\u20090.01) and cortical thickness (difference, \u22120.06 mm; 95% CI, \u22120.10 to \u22120.01 mm; P\u2009=\u20090.02) between CPAP and BSC groups at 6 months after treatment. No serious adverse events occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CPAP improved cortical thickness and FC of DMN, suggesting that patients with OSA may recover from brain atrophic processes after CPAP treatment. However, no improvement in MoCA was found.<\/jats:p>\n                    <jats:p>Clinical trial registered with www.clinicaltrials.gov (NCT02886156).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202406-1170oc","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T10:56:38Z","timestamp":1740480998000},"page":"628-636","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Continuous Positive Airway Pressure on Neuroimaging Biomarkers and Cognition in Adult Obstructive Sleep Apnea: A Randomized Controlled Trial"],"prefix":"10.1093","volume":"211","author":[{"given":"Huajun","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-9998","authenticated-orcid":false,"given":"Chenyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[{"name":"Clinical Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Department of Otorhinolaryngology and"},{"name":"National Health Commission (NHC) Key Laboratory of Otorhinolaryngology, Shandong University Affiliated Qilu Hospital, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, First Affiliated Hospital of Nanchang University, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7256-812X","authenticated-orcid":false,"given":"Weijun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuenan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Department of Otolaryngology Head and Neck Surgery, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Shanghai General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyin","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suru","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanping","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, First Affiliated Hospital of Nanchang University, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Hu","sequence":"additional","affiliation":[{"name":"Nursing Department of Otolaryngology Head and Neck Surgery"},{"name":"Center of Sleep Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Nursing Department of Otolaryngology Head and Neck Surgery"},{"name":"Center of Sleep Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengye","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weituo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Research Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Renji Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Renji Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Shanghai General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Xinhua Hospital, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingrong","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Xinhua Hospital, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyun","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Public Health, Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry"},{"name":"Department of Neurology"},{"name":"Department of Epidemiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-8599","authenticated-orcid":false,"given":"Shankai","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"2026031105273277800_bib1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(13)60734-5","article-title":"Adult obstructive sleep apnoea","volume":"383","author":"Jordan","year":"2014","journal-title":"Lancet"},{"key":"2026031105273277800_bib2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1164\/rccm.202105-1274OC","article-title":"Sleep apnea-specific hypoxic burden, symptom subtypes, and risk of cardiovascular events and all-cause mortality","volume":"205","author":"Trzepizur","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"2026031105273277800_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1164\/rccm.201801-0204PP","article-title":"Obstructive sleep apnea and the risk of cognitive decline in older adults","volume":"199","author":"Gosselin","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2026031105273277800_bib4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1164\/rccm.202306-1101OC","article-title":"Senolytic-facilitated reversal of end-organ dysfunction in a murine model of obstructive sleep apnea","volume":"209","author":"Badran","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2026031105273277800_bib5","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1164\/rccm.202209-1808OC","article-title":"Sleep apnea physiological burdens and cardiovascular morbidity and mortality","volume":"208","author":"Labarca","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"2026031105273277800_bib6","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1164\/rccm.202301-0109OC","article-title":"Ventilatory burden as a measure of obstructive sleep apnea severity is predictive of cardiovascular and all-cause mortality","volume":"208","author":"Parekh","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"2026031105273277800_bib7","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jamaneurol.2017.2180","article-title":"Association of sleep-disordered breathing with cognitive function and risk of cognitive impairment: a systematic review and meta-analysis","volume":"74","author":"Leng","year":"2017","journal-title":"JAMA Neurol"},{"key":"2026031105273277800_bib8","first-page":"613","article-title":"Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women","volume":"306","author":"Yaffe","year":"2011","journal-title":"JAMA"},{"key":"2026031105273277800_bib9","doi-asserted-by":"crossref","first-page":"1133367","DOI":"10.3389\/fnhum.2023.1133367","article-title":"The role of the salience network in cognitive and affective deficits","volume":"17","author":"Schimmelpfennig","year":"2023","journal-title":"Front Hum Neurosci"},{"key":"2026031105273277800_bib10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1212\/WNL.0b013e31823efc6c","article-title":"MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults","volume":"78","author":"Dickerson","year":"2012","journal-title":"Neurology"},{"key":"2026031105273277800_bib11","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1378\/chest.15-0171","article-title":"Effect of CPAP on cognition, brain function, and structure among elderly patients with OSA: a randomized pilot study","volume":"148","author":"Dalmases","year":"2015","journal-title":"Chest"},{"key":"2026031105273277800_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ebiom.2016.03.020","article-title":"Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure","volume":"7","author":"Rosenzweig","year":"2016","journal-title":"EBioMedicine"},{"key":"2026031105273277800_bib13","doi-asserted-by":"crossref","first-page":"e014932","DOI":"10.1136\/bmjopen-2016-014932","article-title":"Effects of continuous positive airway pressure on neurocognitive architecture and function in patients with obstructive sleep apnoea: study protocol for a multicentre randomised controlled trial","volume":"7","author":"Xu","year":"2017","journal-title":"BMJ Open"},{"key":"2026031105273277800_bib14","doi-asserted-by":"crossref","first-page":"1801137","DOI":"10.1183\/13993003.01137-2018","article-title":"Detection of mild cognitive impairment in middle-aged and older adults with obstructive sleep apnoea","volume":"52","author":"Gagnon","year":"2018","journal-title":"Eur Respir J"},{"key":"2026031105273277800_bib15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.sleep.2022.11.037","article-title":"Investigating changes in cognition associated with the use of CPAP in cognitive impairment and dementia: a retrospective study","volume":"101","author":"Costa","year":"2023","journal-title":"Sleep Med"},{"key":"2026031105273277800_bib16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.sleep.2016.01.001","article-title":"Obstructive sleep apnea and cognition in Parkinson\u2019s disease","volume":"21","author":"Harmell","year":"2016","journal-title":"Sleep Med"},{"key":"2026031105273277800_bib17","doi-asserted-by":"crossref","first-page":"5598047","DOI":"10.1155\/2023\/5598047","article-title":"Functional connectivity changes in the insular subregions of patients with obstructive sleep apnea after 6 months of continuous positive airway pressure treatment","volume":"2023","author":"Long","year":"2023","journal-title":"Neural Plast"},{"key":"2026031105273277800_bib18","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41401-019-0323-8","article-title":"Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea","volume":"41","author":"Yang","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"2026031105273277800_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain\u2019s default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"2026031105273277800_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1162\/jocn.2008.21029","article-title":"The common neural basis of autobiographical memory, prospection, navigation, theory of mind, and the default mode: a quantitative meta-analysis","volume":"21","author":"Spreng","year":"2009","journal-title":"J Cogn Neurosci"},{"key":"2026031105273277800_bib21","first-page":"256","article-title":"Decreased Default Mode Network connectivity correlates with age-associated structural and cognitive changes","volume":"6","author":"Vidal-Pineiro","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"2026031105273277800_bib22","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.neuron.2007.10.038","article-title":"Disruption of large-scale brain systems in advanced aging","volume":"56","author":"Andrews-Hanna","year":"2007","journal-title":"Neuron"},{"key":"2026031105273277800_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.sleep.2024.02.021","article-title":"Are there any differences at gray matter sites between severe obstructive sleep apnea patients and healthy controls?","volume":"116","author":"Selcuk","year":"2024","journal-title":"Sleep Med"},{"key":"2026031105273277800_bib24","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s11325-020-02215-w","article-title":"Associations between hypoxia parameters in obstructive sleep apnea and cognition, cortical thickness, and white matter integrity in middle-aged and older adults","volume":"25","author":"Chokesuwattanaskul","year":"2021","journal-title":"Sleep Breath"},{"key":"2026031105273277800_bib25","doi-asserted-by":"crossref","first-page":"e0194555","DOI":"10.1371\/journal.pone.0194555","article-title":"Effectiveness of school food environment policies on children\u2019s dietary behaviors: a systematic review and meta-analysis","volume":"13","author":"Micha","year":"2018","journal-title":"PLoS One"},{"key":"2026031105273277800_bib26","doi-asserted-by":"crossref","first-page":"107823","DOI":"10.1016\/j.heares.2019.107823","article-title":"Cortical thickness of left Heschl\u2019s gyrus correlates with hearing acuity in adults: a surface-based morphometry study","volume":"384","author":"Neuschwander","year":"2019","journal-title":"Hear Res"},{"key":"2026031105273277800_bib27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/cercor\/bhn113","article-title":"The cortical signature of Alzheimer\u2019s disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals","volume":"19","author":"Dickerson","year":"2009","journal-title":"Cereb Cortex"},{"key":"2026031105273277800_bib28","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1212\/01.wnl.0000340981.97664.2f","article-title":"The cortical signature of prodromal AD: regional thinning predicts mild AD dementia","volume":"72","author":"Bakkour","year":"2009","journal-title":"Neurology"},{"key":"2026031105273277800_bib29","doi-asserted-by":"crossref","first-page":"e08901","DOI":"10.1016\/j.heliyon.2022.e08901","article-title":"MRI biomarkers for Alzheimer\u2019s disease: the impact of functional connectivity in the default mode network and structural connectivity between lobes on diagnostic accuracy","volume":"8","author":"Mohtasib","year":"2022","journal-title":"Heliyon"},{"key":"2026031105273277800_bib30","doi-asserted-by":"crossref","first-page":"e1631","DOI":"10.4088\/JCP.15m10413","article-title":"Reduced regional cortical thickness rate of change in donepezil-treated subjects with suspected prodromal Alzheimer\u2019s disease","volume":"77","author":"Cavedo","year":"2016","journal-title":"J Clin Psychiatry"},{"key":"2026031105273277800_bib31","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.euroneuro.2015.12.006","article-title":"Functional connectivity increase in the default-mode network of patients with Alzheimer\u2019s disease after long-term treatment with galantamine","volume":"26","author":"Blautzik","year":"2016","journal-title":"Eur Neuropsychopharmacol"},{"key":"2026031105273277800_bib32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1750-1326-9-16","article-title":"Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP\/Ld transgenic mouse model of Alzheimer\u2019s disease","volume":"9","author":"Kukreja","year":"2014","journal-title":"Mol Neurodegener"},{"key":"2026031105273277800_bib33","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1038\/s41467-023-43627-y","article-title":"Resting-state global brain activity affects early beta-amyloid accumulation in default mode network","volume":"14","author":"Han","year":"2023","journal-title":"Nat Commun"},{"key":"2026031105273277800_bib34","doi-asserted-by":"crossref","first-page":"zsz099","DOI":"10.1093\/sleep\/zsz099","article-title":"The role of sham continuous positive airway pressure as a placebo in controlled trials: Best Apnea Interventions for Research Trial","volume":"42","author":"Reid","year":"2019","journal-title":"Sleep"},{"key":"2026031105273277800_bib35","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1164\/rccm.202005-1868OC","article-title":"Continuous positive airway pressure does not improve nonalcoholic fatty liver disease in patients with obstructive sleep apnea: a randomized clinical trial","volume":"203","author":"Ng","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026031105273277800_bib36","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S2213-2600(14)70172-9","article-title":"Continuous positive airway pressure in older people with obstructive sleep apnoea syndrome (PREDICT): a 12-month, multicentre, randomised trial","volume":"2","author":"McMillan","year":"2014","journal-title":"Lancet Respir Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/211\/4\/628\/67294581\/ajrccm_211_4_628.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/211\/4\/628\/67294581\/ajrccm_211_4_628.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:27:42Z","timestamp":1773221262000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/211\/4\/628\/8513474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4,1]]},"published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202406-1170oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,4,1]]},"assertion":[{"value":"2024-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}