{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:58:09Z","timestamp":1769277489515,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"am","delay-in-days":109,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1164\/rccm.202508-1854le","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:54:29Z","timestamp":1759784069000},"update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":0,"title":["Reply to Yang and Chu: Methodological Considerations in the Iloprost for Septic Shock Trial"],"prefix":"10.1093","author":[{"given":"Fran\u00e7ois","family":"D\u00e9pret","sequence":"first","affiliation":[{"name":"Hopital Saint-Louis , Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chen","sequence":"additional","affiliation":[{"name":"UCSF , San Francisco, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9788-5316","authenticated-orcid":false,"given":"Matthieu","family":"Legrand","sequence":"additional","affiliation":[{"name":"UCSF , Anesthesia and Perioperative Care , San Francisco, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,6]]},"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1164\/rccm.202508-1854LE\/66536033\/rccm.202508-1854le.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1164\/rccm.202508-1854LE\/66536033\/rccm.202508-1854le.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:05:59Z","timestamp":1769159159000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article\/doi\/10.1164\/rccm.202508-1854LE\/8437497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1164\/rccm.202508-1854le","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,6]]},"assertion":[{"value":"2025-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"rccm.202508-1854LE"}}