{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T15:48:12Z","timestamp":1769874492505,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":122,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"DOI":"10.1164\/rccm.202508-2001ed","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T18:33:46Z","timestamp":1757356426000},"page":"1898-1900","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Ionocytes at the Crossroads of Absorption and Secretion: Clues from the Ferret"],"prefix":"10.1093","volume":"211","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-0321","authenticated-orcid":false,"given":"Martina","family":"Gentzsch","sequence":"first","affiliation":[{"name":"Marsico Lung Institute\/Cystic Fibrosis Research Center"},{"name":"Department of Pediatrics, Division of Pediatric Pulmonology"},{"name":"Department of Cell Biology and Physiology The University of North Carolina at Chapel Hill Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"2026013020471780700_bib1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1113\/jphysiol.1932.sp002932","article-title":"\u201cChloride secreting cells\u201d in the gills of fishes, with special reference to the common eel","volume":"76","author":"Keys","year":"1932","journal-title":"J Physiol"},{"key":"2026013020471780700_bib2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41586-018-0394-6","article-title":"A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte","volume":"560","author":"Plasschaert","year":"2018","journal-title":"Nature"},{"key":"2026013020471780700_bib3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41586-018-0393-7","article-title":"A revised airway epithelial hierarchy includes CFTR-expressing ionocytes","volume":"560","author":"Montoro","year":"2018","journal-title":"Nature"},{"key":"2026013020471780700_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1165\/rcmb.2022-0241OC","article-title":"Ionocyte-specific regulation of cystic fibrosis transmembrane conductance regulator","volume":"69","author":"Sato","year":"2023","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026013020471780700_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1165\/rcmb.2022-0280OC","article-title":"Sonic hedgehog signaling is essential for pulmonary ionocyte specification in human and ferret airway epithelia","volume":"69","author":"Cai","year":"2023","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026013020471780700_bib6","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.202309-1565OC","article-title":"Pulmonary ionocytes regulate airway surface liquid pH in primary human bronchial epithelial cells","volume":"210","author":"Luan","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2026013020471780700_bib7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/s41586-023-06549-9","article-title":"Transgenic ferret models define pulmonary ionocyte diversity and function","volume":"621","author":"Yuan","year":"2023","journal-title":"Nature"},{"key":"2026013020471780700_bib8","doi-asserted-by":"crossref","first-page":"e171268","DOI":"10.1172\/JCI171268","article-title":"CFTR-rich ionocytes mediate chloride absorption across airway epithelia","volume":"133","author":"Lei","year":"2023","journal-title":"J Clin Invest"},{"key":"2026013020471780700_bib9","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1164\/rccm.202404-0727ED","article-title":"Pulmonary ionocytes: what are they transporting and which way?","volume":"210","author":"Okuda","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2026013020471780700_bib10","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1164\/rccm.202505-1242OC","article-title":"Ionocyte CFTR coordinates chloride absorption and secretion to balance airway fluid","volume":"211","author":"Yuan","year":"2025","journal-title":"Am J Respir Crit Care Med"},{"key":"2026013020471780700_bib11","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1164\/rccm.202008-3198OC","article-title":"Secretory cells dominate airway CFTR expression and function in human airway superficial epithelia","volume":"203","author":"Okuda","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026013020471780700_bib12","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/s41591-021-01332-7","article-title":"Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition","volume":"27","author":"Carraro","year":"2021","journal-title":"Nat Med"},{"key":"2026013020471780700_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/resp.14833","article-title":"Inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma","volume":"30","author":"Chen","year":"2025","journal-title":"Respirology"},{"key":"2026013020471780700_bib14","doi-asserted-by":"crossref","first-page":"e181995","DOI":"10.1172\/JCI181995","article-title":"IL-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption","volume":"134","author":"Romano Ibarra","year":"2024","journal-title":"J Clin Invest"},{"key":"2026013020471780700_bib15","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1146\/annurev.physiol.68.072304.112754","article-title":"Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress","volume":"68","author":"Tarran","year":"2006","journal-title":"Annu Rev Physiol"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/211\/10\/1898\/66621557\/ajrccm_211_10_1898.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/211\/10\/1898\/66621557\/ajrccm_211_10_1898.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T01:47:25Z","timestamp":1769824045000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/211\/10\/1898\/8444239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":15,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,1]]},"published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.202508-2001ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"2025-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}