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The aim of the present study was to elucidate the role of DCs in granuloma formation. Using a rat model of bacillus Calmette-Gu\u00e9rin (BCG)-elicited pulmonary granulomas, we investigated the distribution of DCs in the granulomas by immunohistochemistry with a rat-DC\u2013specific monoclonal antibody, OX62. We found numerous large, pleiomorphic OX62+ cells accumulating at the borders of the pulmonary granulomas. The OX62+ cells isolated from the granulomatous lung showed intense surface expression of major histocompatibility complex class II, B7\u20131, and B7\u20132, and a lack of T cell\u2013 and monocyte\/macrophage-specific markers. Their ultrastructural morphology was characteristic of DCs. Functionally, they had potent capacity to stimulate allogeneic T cells as well as purified protein derivative-specific syngeneic T cells in the absence of exogenous peptides. Based on these findings, the OX62+ cells infiltrating the granulomas were considered to be DCs expressing BCG-derived peptides. These results indicate that DCs contribute to pulmonary granuloma formation elicited by BCG by means of their potent antigen-presenting function, providing a novel insight into DC function in T cell\u2013mediated granulomatous immune responses.<\/jats:p>","DOI":"10.1164\/rccm.2110086","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T19:17:19Z","timestamp":1027883839000},"page":"1640-1646","source":"Crossref","is-referenced-by-count":25,"title":["Dendritic Cell Involvement in Pulmonary Granuloma Formation Elicited by Bacillus Calmette-Gu\u00e9rin in Rats"],"prefix":"10.1093","volume":"165","author":[{"given":"Tomoyoshi","family":"Tsuchiya","sequence":"first","affiliation":[{"name":"Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan; and Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, 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