{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:59:19Z","timestamp":1775080759222,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Asthma is associated with increased expression of a typical array of genes involved in immune and inflammatory responses, including those encoding the prototypic Th2 cytokines interleukin (IL) 4, IL-5, and IL-13. Most of these genes contain binding sites for activator protein-1 (AP-1) within their promoter and are therefore believed to depend on AP-1 for their expression, suggesting that this transcription factor could be of particular importance in asthma pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To clarify the role of AP-1 in the effector phase of pulmonary allergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ovalbumin (OVA)-sensitized mice were intratracheally given decoy oligodeoxyribonucleotides (ODNs) specifically directed to AP-1 or scrambled control ODNs before challenge with aerosolized OVA. Twenty-four hours after the last OVA challenge, airway hyperresponsiveness was measured and allergic airway inflammation was evaluated quantitatively. AP-1 decoys were localized using flow cytometry and immunohistochemistry. AP-1 activity in the lung was assessed using electrophoretic mobility shift assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Intratracheally delivered AP-1 decoys efficiently targeted airway immune cells, thus precluding AP-1 activation on OVA challenge. Decoy-mediated local inhibition of AP-1 resulted in significant attenuation of all the pathophysiologic features of experimental asthma\u2014namely, eosinophilic airway inflammation, airway hyperresponsiveness, mucous cell hyperplasia, production of allergen-specific immunoglobulins, and synthesis of IL-4, IL-5, and IL-13. Scrambled control ODNs had no detectable effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results reveal a key role for AP-1 in the effector phase of pulmonary allergy and indicate that specific AP-1 inhibition in the airways may have therapeutic value in the control of established asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200410-1431oc","type":"journal-article","created":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T20:55:30Z","timestamp":1118955330000},"page":"671-678","source":"Crossref","is-referenced-by-count":34,"title":["Treatment of Experimental Asthma by Decoy-mediated Local Inhibition of Activator Protein-1"],"prefix":"10.1093","volume":"172","author":[{"given":"Christophe","family":"Desmet","sequence":"first","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Philippe","family":"Gosset","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Emmanuelle","family":"Henry","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Virginie","family":"Garze\u0301","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Pedro","family":"Faisca","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Nanda","family":"Vos","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Fabrice","family":"Jaspar","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Dorothe\u0301e","family":"Me\u0301lotte","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Bart","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Daniel","family":"Desmecht","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Bernard","family":"Pajak","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Muriel","family":"Moser","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de Biologie et de Me\u0301decine Mole\u0301culaires, Universite\u0301 Libre de Bruxelles, Gosselies, Belgium; Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille, Lille, France; and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands"}]},{"given":"Pierre","family":"Lekeux","sequence":"additional","affiliation":[{"name":"Laboratoires de Physiologie and de Pathologie, Faculte\u0301 de Me\u0301decine Ve\u0301te\u0301rinaire, Centre de The\u0301rapie Cellulaire et Mole\u0301culaire, Universite\u0301 de Lie\u0300ge, Lie\u0300ge; Laboratoire de Physiologie Animale, Institut de 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