{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:59:26Z","timestamp":1776851966452,"version":"3.51.2"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Cough can be assessed with visual analog scales (VAS), health status measures, and 24-hour cough frequency monitors (CF24). Evidence for their measurement properties in acute cough caused by upper respiratory tract infection (URTI) and longitudinal data is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess cough longitudinally in URTI with subjective and objective outcome measures and determine sample size for future studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-three previously healthy subjects with URTI completed cough VAS, Leicester Cough Questionnaire (LCQ-acute), and CF24 monitoring (Leicester Cough Monitor) on three occasions, 4 days apart. Changes in subjects\u2019 condition were assessed with a global rating of change questionnaire. The potential for baseline first-hour cough frequency (CF1), VAS, and LCQ to identify low CF24 was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Mean \u00b1 SD duration of cough at visit 1 was 4.1 \u00b1 2.5 days. Geometric mean \u00b1 log SD baseline CF24 and median (interquartile range) cough bouts were high (14.9 \u00b1 0.4 coughs\/h and 85 [39\u2013195] bouts\/24 h). Health status was severely impaired. There was a significant reduction in CF24 and VAS, and improvement in LCQ, from visits 1\u20133. At visit 3, CF24 remained above normal limits in 52% of subjects. The smallest changes in CF24, LCQ, and VAS that subjects perceived important were 54%, 2- and 17-mm change from baseline, respectively. The sample sizes required for parallel group studies to detect these changes are 27, 51, and 25 subjects per group, respectively. CF1 (&amp;lt;20.5 coughs\/h) was predictive of low CF24.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CF24, VAS, and LCQ are responsive outcome tools for the assessment of acute cough. The smallest change in cough frequency perceived important by subjects is 54%. The sample sizes required for future studies are modest and achievable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201209-1686oc","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T22:15:14Z","timestamp":1362694514000},"page":"991-997","source":"Crossref","is-referenced-by-count":65,"title":["A Longitudinal Assessment of Acute Cough"],"prefix":"10.1093","volume":"187","author":[{"given":"Kai K.","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Asthma, Allergy and Lung Biology, Denmark Hill Campus, and"}]},{"given":"Sergio","family":"Matos","sequence":"additional","affiliation":[{"name":"Institute of Electronics and Telematics Engineering, University of Aveiro, Aveiro, Portugal"}]},{"given":"David H.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Leicester Royal Infirmary, Leicester, United Kingdom; and"}]},{"given":"Patrick","family":"White","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Public Health Sciences, King\u2019s Health Partners, King\u2019s College London, London, United Kingdom"}]},{"given":"Ian D.","family":"Pavord","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Glenfield Hospital, Institute for Lung Health, Leicester, United Kingdom"}]},{"given":"Surinder S.","family":"Birring","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy and Lung Biology, Denmark Hill Campus, and"}]}],"member":"286","published-online":{"date-parts":[[2013,5,1]]},"reference":[{"key":"2026032100541276400_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1378\/chest.114.2_Supplement.133S","article-title":"Managing cough as a defense mechanism and as a symptom: a consensus panel report of the American College of Chest 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