{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:13:54Z","timestamp":1773706434401,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Inhaled Antibiotic for Bronchiectasis and Cystic Fibrosis"},{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008593","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Inhaled Antibiotic for Bronchiectasis and Cystic Fibrosis"},{"DOI":"10.13039\/100008593","name":"Chief Scientist Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>COPD and bronchiectasis are commonly reported together. Studies report varying impacts of co-diagnosis on outcomes, which may be related to different definitions of disease used across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the prevalence of chronic obstructive pulmonary disease (COPD) associated with bronchiectasis and its relationship with clinical outcomes. We further investigated the impact of implementing the standardized ROSE criteria (radiological bronchiectasis [R], obstruction [FEV1\/FVC ratio &amp;lt;0.7; O], symptoms [S], and exposure [\u2a7e10 pack-years of smoking; E]), an objective definition of the association of bronchiectasis with COPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Analysis of the EMBARC (European Bronchiectasis Registry), a prospective observational study of patients with computed tomography\u2013confirmed bronchiectasis from 28 countries. The ROSE criteria were used to objectively define the association of bronchiectasis with COPD. Key outcomes during a maximum of 5\u2009years of follow-up were exacerbations, hospitalization, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>A total of 16,730 patients with bronchiectasis were included; 4,336 had a clinician-assigned codiagnosis of COPD, and these patients had more exacerbations, worse quality of life, and higher severity scores. We observed marked overdiagnosis of COPD: 22.2% of patients with a diagnosis of COPD did not have airflow obstruction and 31.9% did not have a history of \u2a7e10 pack-years of smoking. Therefore, 2,157 patients (55.4%) met the ROSE criteria for COPD. Compared with patients without COPD, patients who met the ROSE criteria had increased risks of exacerbations and exacerbations resulting in hospitalization during follow-up (incidence rate ratio, 1.25; 95% confidence interval, 1.15\u20131.35; vs. incidence rate ratio, 1.69; 95% confidence interval, 1.51\u20131.90, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The label of COPD is often applied to patients with bronchiectasis who do not have objective evidence of airflow obstruction or a smoking history. Patients with a clinical label of COPD have worse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.202309-1614oc","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T16:56:36Z","timestamp":1706201796000},"page":"119-127","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":38,"title":["The Association between Bronchiectasis and Chronic Obstructive Pulmonary Disease: Data from the European Bronchiectasis Registry (EMBARC)"],"prefix":"10.1093","volume":"210","author":[{"given":"Eva","family":"Polverino","sequence":"first","affiliation":[{"name":"Pneumology Department, Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Institut de Recerca, Vall d\u2019Hebron Barcelona Hospital Campus, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias, Barcelona, Spain"},{"name":"Thorax Institute, Institute of Biomedical Research August Pi i Sunyer, University of Barcelona, Barcelona, Spain"}]},{"given":"Anthony","family":"De Soyza","sequence":"additional","affiliation":[{"name":"Population and Health Science Institute, Newcastle University and National Institute for Health and Care Research Biomedical Research Centre for Ageing, Freeman Hospital, Newcastle, United Kingdom"}]},{"given":"Katerina","family":"Dimakou","sequence":"additional","affiliation":[{"name":"5th Respiratory Department and Bronchiectasis Unit, \u201cSotiria\u201d General Hospital of Chest Diseases, Athens, Greece"}]},{"given":"Letizia","family":"Traversi","sequence":"additional","affiliation":[{"name":"Pneumology Department, Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Institut de Recerca, Vall d\u2019Hebron Barcelona Hospital Campus, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-2690","authenticated-orcid":false,"given":"Apostolos","family":"Bossios","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Division of Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden"}]},{"given":"Megan L.","family":"Crichton","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom"}]},{"given":"Felix C.","family":"Ringshausen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hanover, Germany"},{"name":"Biomedical Research in End-Stage and Obstructive Lung Disease Hannover, German Center for Lung Research, Hanover, Germany"},{"name":"European Reference Network on Rare and Complex Respiratory Diseases, Frankfurt, Germany"}]},{"given":"Montserrat","family":"Vendrell","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Dr. Trueta University Hospital, Girona Biomedical Research Institute, University of Girona, Spain"}]},{"given":"Pierre-R\u00e9gis","family":"Burgel","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and French Cystic Fibrosis National Reference Center, H\u00f4pital Cochin, Assistance Publique\u2013H\u00f4pitaux de Paris, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1016, Institut Cochin, Paris, France"}]},{"given":"Charles S.","family":"Haworth","sequence":"additional","affiliation":[{"name":"Cambridge Centre for Lung Infection, Royal Papworth Hospital and University of Cambridge, Cambridge, United Kingdom"}]},{"given":"Michael R.","family":"Loebinger","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield Hospitals and National Heart and Lung Institute, Imperial College London, United Kingdom"}]},{"given":"Natalie","family":"Lorent","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium"}]},{"given":"Isabell","family":"Pink","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hanover, Germany"},{"name":"Biomedical Research in End-Stage and Obstructive Lung Disease Hannover, German Center for Lung Research, Hanover, Germany"},{"name":"European Reference Network on Rare and Complex Respiratory Diseases, Frankfurt, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5721-5710","authenticated-orcid":false,"given":"Melissa","family":"McDonnell","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Galway University Hospital, Galway, Ireland"}]},{"given":"Sabina","family":"Skrgat","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases and Allergy, University Medical Centre Ljubljana, Ljubljana, Slovenia"},{"name":"Medical Faculty, University of Ljubljana, Ljubljana, Slovenia"},{"name":"University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia"}]},{"given":"Luis M.","family":"Carro","sequence":"additional","affiliation":[{"name":"Chronic Bronchial Infection Unit, Pneumology Service, Ram\u00f3n y Cajal Hospital, Alcal\u00e1 de Henares University, Madrid, Spain"}]},{"given":"Oriol","family":"Sibila","sequence":"additional","affiliation":[{"name":"Servicio de Neumolog\u00eda, Instituto Cl\u00ednico de Respiratorio, Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer, Hospital Cl\u00ednic, University of Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias, Instituto 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Jo\u00e3o, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Jeremy S.","family":"Brown","sequence":"additional","affiliation":[{"name":"UCL Respiratory, University College London, London, United Kingdom"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-6040","authenticated-orcid":false,"given":"John R.","family":"Hurst","sequence":"additional","affiliation":[{"name":"UCL Respiratory, University College London, London, United Kingdom"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9850-9520","authenticated-orcid":false,"given":"Marc","family":"Miravitlles","sequence":"additional","affiliation":[{"name":"Pneumology Department, Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Institut de Recerca, Vall d\u2019Hebron Barcelona Hospital Campus, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3592-3839","authenticated-orcid":false,"given":"Rosario","family":"Menendez","sequence":"additional","affiliation":[{"name":"Pneumology Department, Hospital Universitario y Polit\u00e9cnico La Fe\u2013Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8643-2167","authenticated-orcid":false,"given":"Antoni","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Hospital Clinic of Barcelona, University of Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias, Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer, Instituci\u00f3n Catalana de Investigaci\u00f3n y Estudios Avanzados, Barcelona, Spain"}]},{"given":"Tobias","family":"Welte","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hanover, Germany"},{"name":"Biomedical Research in End-Stage and Obstructive Lung Disease Hannover, German Center for Lung Research, Hanover, Germany"},{"name":"European Reference Network on Rare and Complex Respiratory Diseases, Frankfurt, Germany"}]},{"given":"Francesco","family":"Blasi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, University of Milan, Italy"},{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}]},{"given":"Josje","family":"Altenburg","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centres, Amsterdam, the Netherlands"},{"name":"Department of Pulmonary Diseases, Amsterdam University Medical Centres, Amsterdam, the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-3398","authenticated-orcid":false,"given":"Michal","family":"Shteinberg","sequence":"additional","affiliation":[{"name":"Pulmonology Institute and CF Center, Carmel Medical Center, Haifa, Israel"},{"name":"Technion\u2013Israel Institute of Technology, B. 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