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In this study, well differentiated primary human airway epithelial cells were infected with either RV16 (major group) or RV1B (minor group). Transcriptional gene profiles from RV-infected and mock-infected control cells were analyzed by Affymetrix Genechip, and changes of the gene expression were confirmed by real-time RT-PCR analysis. At 24 h after infection, 48 genes induced by both viruses were identified. Most of these genes are related to the IFN pathway, and have been documented to have antiviral functions. Indeed, a significant stimulation of IFN-\u03b2 secretion was detected after RV16 infection. Neutralizing antibody specific to IFN-\u03b2 and a specific inhibitor of the Janus kinase pathway both significantly blocked the induction of RV-inducible genes. Further studies demonstrated that 2-aminopurine, a specific inhibitor double-stranded RNA\u2013dependent protein kinase, could block both IFN-\u03b2 production and RV-induced gene expression. Thus, IFN-\u03b2\u2013dependent pathway is a part of the double-stranded RNA\u2013initiated pathway that is responsible for RV-induced gene expression. Consistent with its indispensable role in the induction of antiviral genes, deactivation of this signaling pathway significantly enhanced viral production. Because increase of viral yield is associated with the severity of RV-induced airway illness, the discovery of an epithelial antiviral signaling pathway in this study will contribute to our understanding of the pathogenesis of RV-induced colds and asthma exacerbations.<\/jats:p>","DOI":"10.1165\/rcmb.2004-0417oc","type":"journal-article","created":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T20:45:25Z","timestamp":1128631525000},"page":"192-203","source":"Crossref","is-referenced-by-count":100,"title":["Rhinovirus Induces Airway Epithelial Gene Expression through Double-Stranded RNA and IFN-Dependent Pathways"],"prefix":"10.1093","volume":"34","author":[{"given":"Yin","family":"Chen","sequence":"first","affiliation":[{"name":"University of California at Davis, Davis; California Department of Health Services, Richmond; University of California at San Francisco, San Francisco, California; and University of Wisconsin, Madison, 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