{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:19:04Z","timestamp":1774567144754,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human leukocyte antigen (HLA)-DQB1 is one of the intriguing candidate genes in sarcoidosis. We performed high resolution molecular HLA-DQB1 typing on two groups of white patients (British [UK] and Dutch [NL]) in order to investigate the relationship between 19 DQB1 alleles and disease severity and progression. A total of 803 individuals were studied (133 UK and 102 NL patients, and 354 UK and 214 NL control subjects). Disease severity data included extrapulmonary disease, chest X-ray stage, lung diffusing capacity for carbon monoxide, and FVC. Progression was evaluated on follow-up chest radiographs (2 and 4 yr). The results showed DQB1*0201 to be strongly protective against severe sarcoidosis in both populations; in other words, it localized to Stage I at all time points (P &amp;lt; 0.0001, Pcorrected (Pc) = 0.002), whereas another DQB1 allele, *0602, tended to have opposite effects. Further, a clear association was found between the *0201 allele and L\u00f6fgren's syndrome (P &amp;lt; 0.0001, Pc \u00a0= 0.001). More importantly, carriage of this allele reduced the risk of disease progression. In contrast, the other common split of DQB1*02, *0202, did not affect disease severity but was mildly protective against sarcoidosis in the UK population (P \u00a0= 0.02, pc not significant). In conclusion, this study shows that DQB1*0201 is a strong marker for mild sarcoidosis. Additional mapping across the DQB1*0201-DRB1*0301 haplotype, including specific alleles at genes such as DRB3, tumor necrosis factor, lymphotoxin-\u03b1, I-kappa-B-like protein, and B-associated transcript 1, is necessary for a final localization of the protective effect on this haplotype.<\/jats:p>","DOI":"10.1165\/rcmb.4782","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T21:19:39Z","timestamp":1365023979000},"page":"406-412","source":"Crossref","is-referenced-by-count":124,"title":["HLA-DQB1*0201"],"prefix":"10.1093","volume":"27","author":[{"given":"Hiroe","family":"Sato","sequence":"first","affiliation":[{"name":"Clinical Genomics Group, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom; Heart Lung Center Utrecht, Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, The Netherlands; Department of Gastroenterology, Radcliffe Hospital, Oxford, United Kingdom; Department of Medical Microbiology & Immunology, Sint Antonius Hospital, Nieuwegein; and Heart Lung Center Utrecht, Department of Pulmonology, University Medical Center, Utrecht, The Netherlands"}]},{"given":"Jan C.","family":"Grutters","sequence":"additional","affiliation":[{"name":"Clinical Genomics Group, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom; Heart Lung Center Utrecht, Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, The Netherlands; Department of Gastroenterology, Radcliffe Hospital, Oxford, United Kingdom; Department of Medical Microbiology & Immunology, Sint Antonius Hospital, Nieuwegein; and Heart Lung Center Utrecht, Department of Pulmonology, University Medical Center, Utrecht, The Netherlands"}]},{"given":"Panagiotis","family":"Pantelidis","sequence":"additional","affiliation":[{"name":"Clinical Genomics Group, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom; Heart Lung Center Utrecht, Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, The Netherlands; Department of Gastroenterology, Radcliffe Hospital, Oxford, United Kingdom; Department of Medical Microbiology & Immunology, Sint Antonius Hospital, Nieuwegein; and Heart Lung Center Utrecht, Department of Pulmonology, University Medical Center, Utrecht, The Netherlands"}]},{"given":"A. Neil","family":"Mizzon","sequence":"additional","affiliation":[{"name":"Clinical Genomics Group, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom; Heart Lung Center Utrecht, Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, The Netherlands; Department of Gastroenterology, Radcliffe Hospital, Oxford, United Kingdom; Department of Medical Microbiology & Immunology, Sint Antonius Hospital, Nieuwegein; and Heart Lung Center Utrecht, Department of Pulmonology, University Medical Center, Utrecht, The Netherlands"}]},{"given":"Tariq","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Clinical Genomics Group, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom; Heart Lung Center Utrecht, Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, The Netherlands; Department of Gastroenterology, Radcliffe Hospital, Oxford, United Kingdom; Department of Medical Microbiology & Immunology, Sint Antonius Hospital, Nieuwegein; and Heart Lung Center Utrecht, Department of Pulmonology, University Medical Center, Utrecht, The Netherlands"}]},{"given":"Arend-Jan","family":"van Houte","sequence":"additional","affiliation":[{"name":"Clinical Genomics Group, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom; Heart Lung Center Utrecht, Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, The Netherlands; Department of Gastroenterology, Radcliffe Hospital, Oxford, United Kingdom; Department of Medical Microbiology & Immunology, Sint Antonius Hospital, Nieuwegein; and Heart Lung Center Utrecht, Department of Pulmonology, University Medical Center, Utrecht, The Netherlands"}]},{"given":"Jan-Willem J.","family":"Lammers","sequence":"additional","affiliation":[{"name":"Clinical Genomics Group, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom; Heart Lung Center Utrecht, Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, The Netherlands; Department of Gastroenterology, Radcliffe Hospital, Oxford, United Kingdom; Department of Medical Microbiology & Immunology, Sint Antonius Hospital, Nieuwegein; and Heart Lung Center Utrecht, Department of Pulmonology, University Medical Center, Utrecht, The Netherlands"}]},{"given":"Jules M.M.","family":"van den Bosch","sequence":"additional","affiliation":[{"name":"Clinical Genomics Group, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom; Heart Lung Center Utrecht, Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, The Netherlands; Department of Gastroenterology, Radcliffe Hospital, Oxford, United Kingdom; Department of Medical Microbiology & Immunology, Sint Antonius Hospital, Nieuwegein; and Heart Lung Center Utrecht, Department of Pulmonology, University Medical Center, Utrecht, The Netherlands"}]},{"given":"Kenneth I.","family":"Welsh","sequence":"additional","affiliation":[{"name":"Clinical Genomics Group, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom; Heart Lung Center Utrecht, Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, The Netherlands; Department of Gastroenterology, Radcliffe Hospital, Oxford, United Kingdom; Department of Medical Microbiology & Immunology, Sint Antonius Hospital, Nieuwegein; and Heart Lung Center Utrecht, Department of Pulmonology, University Medical Center, Utrecht, The Netherlands"}]},{"given":"Roland M.","family":"du Bois","sequence":"additional","affiliation":[{"name":"Clinical Genomics Group, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom; Heart Lung Center Utrecht, Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, The Netherlands; Department of Gastroenterology, Radcliffe Hospital, Oxford, United Kingdom; Department of Medical Microbiology & Immunology, Sint Antonius Hospital, Nieuwegein; and Heart Lung Center Utrecht, Department of Pulmonology, University Medical Center, Utrecht, The Netherlands"}]}],"member":"286","published-online":{"date-parts":[[2002,10,1]]},"reference":[{"key":"2026030623545619700_BIB1","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1056\/NEJM199704243361706","volume":"336","year":"1997","journal-title":"N. 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