{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:15:28Z","timestamp":1776233728085,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We previously demonstrated that resident alveolar macrophages from naive mice do not synthesize interleukin (IL)-10, whereas mononuclear phagocytes (MP) recruited during the lung inflammatory process are transiently competent for IL-10 production when exposed to lipopolysaccharide (LPS) in vitro. As surfactant protein A (SP-A), a member of the collectin family, inhibits LPS-induced in vitro IL-10 formation by bone marrow\u2013derived macrophages, we studied its effect on MP under in vivo inflammatory conditions. When mice with LPS-induced inflamed lungs were given a second intranasal LPS administration, IL-10 concentration recovered in the bronchoalveolar lavage fluids varied as a function of the time interval between the two LPS doses. Thus, IL-10 concentration increased with the number of MP up to Day 3, and then decreased to undetectable values within 24 h, despite a continued increase in the number of MP. Analysis of IL-10 mRNA from purified MP indicated that gene expression correlated with the IL-10 level in the bronchoalveolar lavage fluid. In contrast to IL-10 production, SP-A concentrations during LPS-induced inflammation decreased with a nadir at Day 3, and then increased significantly within 24 h. Furthermore, intranasal administration of exogenous SP-A to mice with LPS-induced inflamed lungs led to a repression of the IL-10 production. In summary, this study demonstrates for the first time an in vivo inhibitory role of SP-A on the anti-inflammatory activity of MP, through inhibition of IL-10 production.<\/jats:p>","DOI":"10.1165\/rcmb.4883","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T19:35:10Z","timestamp":1045683310000},"page":"347-353","source":"Crossref","is-referenced-by-count":22,"title":["Surfactant Protein A Inhibits Lipopolysaccharide-Induced\n                    <i>In Vivo<\/i>\n                    Production of Interleukin-10 by Mononuclear Phagocytes during Lung Inflammation"],"prefix":"10.1093","volume":"28","author":[{"given":"Sophie","family":"Chabot","sequence":"first","affiliation":[{"name":"Unit\u00e9 de D\u00e9fense Inn\u00e9e et Inflammation, Unit\u00e9 Associ\u00e9e Institut Pasteur\/Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U485, Paris, France; and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Cincinnati, Cincinnati, Ohio"}]},{"given":"Laurent","family":"Salez","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de D\u00e9fense Inn\u00e9e et Inflammation, Unit\u00e9 Associ\u00e9e Institut Pasteur\/Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U485, Paris, France; and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Cincinnati, Cincinnati, Ohio"}]},{"given":"Francis X.","family":"McCormack","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de D\u00e9fense Inn\u00e9e et Inflammation, Unit\u00e9 Associ\u00e9e Institut Pasteur\/Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U485, Paris, France; and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Cincinnati, Cincinnati, Ohio"}]},{"given":"Lhousseine","family":"Touqui","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de D\u00e9fense Inn\u00e9e et Inflammation, Unit\u00e9 Associ\u00e9e Institut Pasteur\/Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U485, Paris, France; and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Cincinnati, Cincinnati, Ohio"}]},{"given":"Michel","family":"Chignard","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de D\u00e9fense Inn\u00e9e et Inflammation, Unit\u00e9 Associ\u00e9e Institut Pasteur\/Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U485, Paris, France; and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Cincinnati, Cincinnati, Ohio"}]}],"member":"286","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"2026030623531272800_BIB1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1136\/thx.52.2.195","volume":"52","year":"1997","journal-title":"Thorax"},{"key":"2026030623531272800_BIB2","first-page":"S415","volume":"21","year":"1993","journal-title":"Crit. 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