{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:01:56Z","timestamp":1773838916882,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1990,10,1]],"date-time":"1990-10-01T00:00:00Z","timestamp":654739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systemic administration of interleukin (IL)-2 to patients with malignant diseases induces peripheral eosinophilia. In the present study, to clarify the mechanism of eosinophilia induced by IL-2, we examined the changes in the number of eosinophils and eosinophil colony-stimulating factor (Eo-CSF) activity in the pleural fluids of six patients with malignant pleurisy caused by lung cancer or malignant mesothelioma during and after intrapleural administration of IL-2. Results showed that intrapleural administration of IL-2 induced marked eosinophilia in the pleural fluid and moderate eosinophilia in the peripheral blood, and that during IL-2 administration, marked Eo-CSF activity appeared in the pleural fluid before increase in the number of eosinophils, but that this activity did not appear in the peripheral blood. This Eo-CSF activity was inhibited by a combination of anti-IL-5 antibody, anti-IL-3 antibody, and anti-granulocyte\/macrophage colony-stimulating factor (anti-GM-CSF) antibody, but not by each antibody alone. Chemotactic activity for eosinophils was also detected in the pleural fluid during IL-2 treatment. These results suggest that eosinophilia in the pleural fluid induced by IL-2 injection into the pleural cavity of patients with malignant pleurisy is due to the Eo-CSF activities of various components, including IL-5, IL-3, and GM-CSF, and chemotactic factors for eosinophils induced locally in the pleural cavity by IL-2.<\/jats:p>","DOI":"10.1165\/ajrcmb\/3.4.291","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T23:17:12Z","timestamp":1365031032000},"page":"291-300","source":"Crossref","is-referenced-by-count":21,"title":["Eosinophil Colony-stimulating Factor Induced by Administration of Interleukin-2 into the Pleural Cavity of Patients with Malignant Pleurisy"],"prefix":"10.1093","volume":"3","author":[{"given":"Yoichi","family":"Nakamura","sequence":"first","affiliation":[{"name":"Third Department of Internal Medicine, University of Tokushima, School of Medicine, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, University of Tokushima, School of Medicine, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Yanagawa","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, University of Tokushima, School of Medicine, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Yasuoka","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, University of Tokushima, School of Medicine, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ogura","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, University of Tokushima, School of Medicine, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,10,1]]},"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/3\/4\/291\/67277984\/ajrcmb_3_4_291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/3\/4\/291\/67277984\/ajrcmb_3_4_291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:34:43Z","timestamp":1773826483000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/3\/4\/291\/8511847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1990,10,1]]},"published-print":{"date-parts":[[1990,10,1]]}},"URL":"https:\/\/doi.org\/10.1165\/ajrcmb\/3.4.291","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,10]]},"published":{"date-parts":[[1990,10,1]]}}}