{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:59:22Z","timestamp":1773838762888,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1990,10,1]],"date-time":"1990-10-01T00:00:00Z","timestamp":654739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lipocortin I mediates, in part, the anti-inflammatory effects of corticosteroids. To determine whether alveolar epithelial cells produce lipocortin I, we used a highly specific anti-lipocortin I antibody and found by the techniques of Western blotting and immunocytochemical analysis that lipocortin I is a normal constituent of type II alveolar epithelial cells and that it constitutes approximately 0.1% of cell lysate proteins. Two separate species of lipocortin I were identified, migrating with molecular weights of 37 and 32 kD. Dexamethasone caused a dose-dependent increase in lipocortin I in rat alveolar epithelial cells, and its effect was maximal at a dose of 10\u22125 M. This effect was specific for corticosteroids since it was not seen with other steroids. These studies suggest that lipocortin I may mediate, in part, the immunosuppressive effects of corticosteroids in the lower respiratory tract.<\/jats:p>","DOI":"10.1165\/ajrcmb\/3.4.349","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T23:17:12Z","timestamp":1365031032000},"page":"349-353","source":"Crossref","is-referenced-by-count":40,"title":["Corticosteroids Increase Lipocortin I in Alveolar Epithelial Cells"],"prefix":"10.1093","volume":"3","author":[{"given":"M. P.","family":"Ambrose","sequence":"first","affiliation":[{"name":"Pulmonary Division, Department of Medicine, Department of Veterans Affairs, and University of Iowa, College of Medicine, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. W.","family":"Hunninghake","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Department of Medicine, Department of Veterans Affairs, and University of Iowa, College of Medicine, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,10,1]]},"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/3\/4\/349\/67277972\/ajrcmb_3_4_349.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/3\/4\/349\/67277972\/ajrcmb_3_4_349.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:33:25Z","timestamp":1773826405000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/3\/4\/349\/8511841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1990,10,1]]},"published-print":{"date-parts":[[1990,10,1]]}},"URL":"https:\/\/doi.org\/10.1165\/ajrcmb\/3.4.349","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,10]]},"published":{"date-parts":[[1990,10,1]]}}}