{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T15:10:57Z","timestamp":1773846657859,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1992,12,1]],"date-time":"1992-12-01T00:00:00Z","timestamp":723168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eosinophilia and eosinophil function are regulated by cytokines such as granulocyte\/macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5). We have investigated the modulatory role of IL-5 on N-formyl-methionyl-leucyl-phenylalanine (FMLP), neutrophil-activating factor (NAF\/IL-8), platelet factor 4 (PF4), and cytokine-induced chemotaxis of eosinophils from normal individuals. These eosinophils show a small chemotactic response toward PF4 but not to NAF\/IL-8 and FMLP Preincubation of eosinophils with low concentrations of IL-5 caused significantly increased responses toward PF4 and induced a significant chemotactic response toward FMLP and NAF\/IL-8. In marked contrast, IL-5 (or IL-3) priming of eosinophils from normal donors resulted in a strong inhibition of GM-CSF-induced chemotaxis. A similar decrease in the chemotactic response toward GM-CSF was observed in eosinophils derived from allergic asthmatic individuals. This finding suggests that the latter eosinophils may have had a prior exposure to IL-5 (or IL-3). Washing of the cells after priming did not abrogate the inhibition of the GM-CSF response. Our data indicate that at low concentrations IL-5 is an important modulator of eosinophil chemotaxis, causing selective upregulation or downregulation of chemotactic responses toward different agents.<\/jats:p>","DOI":"10.1165\/ajrcmb\/7.6.631","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T22:58:31Z","timestamp":1365029911000},"page":"631-636","source":"Crossref","is-referenced-by-count":78,"title":["Modulation of Eosinophil Chemotaxis by Interleukin-5"],"prefix":"10.1093","volume":"7","author":[{"given":"R. A. J.","family":"Warringa","sequence":"first","affiliation":[{"name":"Department of Pulmonary Diseases, University Hospital Utrecht, Utrecht, The Netherlands, and Swiss Institute of Allergy and Asthma Research, Davos, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University Hospital Utrecht, Utrecht, The Netherlands, and Swiss Institute of Allergy and Asthma Research, Davos, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Maikoe","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University Hospital Utrecht, Utrecht, The Netherlands, and Swiss Institute of Allergy and Asthma Research, Davos, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. H. M.","family":"Kuijper","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University Hospital Utrecht, Utrecht, The Netherlands, and Swiss Institute of Allergy and Asthma Research, Davos, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L. B.","family":"Bruijnzeel","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University Hospital Utrecht, Utrecht, The Netherlands, and Swiss Institute of Allergy and Asthma Research, Davos, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Koenderman","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University Hospital Utrecht, Utrecht, The Netherlands, and Swiss Institute of Allergy and Asthma Research, Davos, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,12,1]]},"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/7\/6\/631\/67276666\/ajrcmb_7_6_631.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/7\/6\/631\/67276666\/ajrcmb_7_6_631.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:55:14Z","timestamp":1773827714000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/7\/6\/631\/8511518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1992,12,1]]},"published-print":{"date-parts":[[1992,12,1]]}},"URL":"https:\/\/doi.org\/10.1165\/ajrcmb\/7.6.631","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,12]]},"published":{"date-parts":[[1992,12,1]]}}}