{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:33:37Z","timestamp":1780598017303,"version":"3.54.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1994,9,1]],"date-time":"1994-09-01T00:00:00Z","timestamp":778377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute lung injury, characterized as the adult respiratory distress syndrome (ARDS), is a common clinical occurrence following blood loss and injury. We previously found increased levels of transforming growth factor (TGF)-\u03b21 mRNA in murine intraparenchymal mononuclear cells and in alveolar macrophages within 1 h after hemorrhage. Because TGF-\u03b2 has potent proinflammatory and immunoregulatory properties, we investigated the effect of blocking TGF-\u03b2 with mAb on hemorrhage-induced pathology, cytokine mRNA levels in lungs, as well as survival from pneumonia. Mice treated with anti-TGF-\u03b2 mAb showed normal pulmonary histology 3 days after hemorrhage and resuscitation in contrast to the mononuclear and neutrophil infiltrates, intraalveolar hemorrhage, and interstitial edema found in hemorrhaged mice either treated with control antibody or not treated with any antibody. Decreased mRNA levels for IL-1 \u03b2, TNF-\u03b1, IL-6, IL-10, and IFN-\u03b3 as compared with untreated, hemorrhaged controls were present in intraparenchymal pulmonary mononuclear cells following therapy with anti-TGF-\u03b2. In contrast, therapy with anti-TGF-\u03b2 increased mRNA levels for IL-1 \u03b2 and TNF-\u03b1 in alveolar macrophages and for TGF-\u03b2 in peripheral blood mononuclear cells collected 3 days after hemorrhage. Administration of anti-TGF-\u03b2 to hemorrhaged mice did not correct the enhanced susceptibility to Pseudomonas aeruginosa pneumonia that exists after hemorrhage. These results suggest that TGF-\u03b2 has an important role in hemorrhage-induced acute lung injury, but does not contribute to the post-hemorrhage depression in pulmonary antibacterial response.<\/jats:p>","DOI":"10.1165\/ajrcmb.11.3.8086171","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T22:29:18Z","timestamp":1365028158000},"page":"351-357","source":"Crossref","is-referenced-by-count":41,"title":["Anti-Transforming Growth Factor-\u03b2 Monoclonal Antibodies Prevent Lung Injury in Hemorrhaged Mice"],"prefix":"10.1093","volume":"11","author":[{"given":"R","family":"Shenkar","sequence":"first","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W F","family":"Coulson","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Abraham","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1994,9,1]]},"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/11\/3\/351\/67373159\/ajrcmb_11_3_351.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/11\/3\/351\/67373159\/ajrcmb_11_3_351.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:53:57Z","timestamp":1773723237000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/11\/3\/351\/8525236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1994,9,1]]},"published-print":{"date-parts":[[1994,9,1]]}},"URL":"https:\/\/doi.org\/10.1165\/ajrcmb.11.3.8086171","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,9]]},"published":{"date-parts":[[1994,9,1]]}}}